Evaluation of Measured and Predicted Environmental Concentrations of Selected Human Pharmaceuticals and Personal Care Products (10 pp)

Liebig, Markus; Moltmann, Johann F.; Knacker, Thomas

doi:10.1065/espr2005.08.276

Cited by 75 publications

(38 citation statements)

References 45 publications

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“…La contamination environnementale par des résidus de médicaments est aujourd'hui clairement démontrée par de nombreuses études de terrain et font des rejets médicamenteux un problème environnemental émergent. [2][3][4][5][6] Des résidus médicamenteux ont été retrouvés dans les eaux superficielles, eaux souterraines, eaux résiduaires, boues de staPour la liste des participants, voir en fin d'article tion d'épuration mais aussi dans certains échantillons d'eau de boisson.…”

Section: Introductionunclassified

Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

Defarges¹,

Guerbet

Massol

2011

Therapies

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Section: Introductionunclassified

Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

Defarges¹,

Guerbet

Massol

2011

Therapies

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“…In particular, he strongly contributed to the development of concepts for the evaluation and management of pharmaceuticals [16][17][18]. Recently, Thomas focused his activities on the outcome of the ERAPharm project [19][20][21][22][23].…”

Section: Dr Jörg Römbke Dr Anja Coorsmentioning

confidence: 99%

A farewell to Dr Thomas Knacker (* 29.04.1951 – † 30.10.2011): scientific contributions and personal memories

Römbke

Coors

Fenner³

et al. 2012

Environ Sci Eur

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“…We studied the carcinostatic activity of diverse aromatics in a series screening anticancer agents (4,5) and found Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyltetrahydronaphthalene, AHTN), an aromatic widely used in some detergents or soaps, to have carcinostatic activities. The antitumor effects of tonalide remain to be elucidated, whereas its toxicity has been reported in environmental (6)(7)(8) and biological (9)(10)(11) studies.…”

Section: Introductionmentioning

confidence: 99%

“…Antitumor activities have been reported for the aromatics Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyl-tetrahydronaphthalene, AHTN) and Pearlide (1,3,4,6,7,6,6,7,8, HHCB), which are contained in detergents. In this study, their carcinostatic activities in Ehrlich ascites tumor (EAT) cells were evaluated by mitochondrial dehydroganase-based WST-1 assay and dye-exclusion assay.…”

mentioning

confidence: 99%

The antitumor activities of the structurally-similar two-species aromatics Tonalide and Pearlide and the enhancement of their effects by hyperthermia

Asada

Kageyama²,

Tanaka³

et al. 2008

Mol Med Rep

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Abstract. Antitumor activities have been reported for the aromatics Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyl-tetrahydronaphthalene, AHTN) and Pearlide (1,3,4,6,7,6,6,7,8, HHCB), which are contained in detergents. In this study, their carcinostatic activities in Ehrlich ascites tumor (EAT) cells were evaluated by mitochondrial dehydroganase-based WST-1 assay and dye-exclusion assay. The viability of EAT cells treated at 37 or 42˚C for 30 min and sequentially cultured at 37˚C was assayed at graded times. Immediately after treatment at 37˚C, neither Tonalide nor Pearlide had an effect on EAT cells, even at a concentration as high as 200 μM. However, cell viability was reduced to 40% versus the control after 20 h of culture with Tonalide at 50 μM, and to below 20% at 25 μM after 72 h. In contrast, Pearlide was nearly inactive, even at a dose of 100 μM after 20 h of culture, and only reduced cell viability to 41.2% after 72 h. After treatment at 42˚C without culture, neither of the aromatics was effective, even at a dose of 200 μM. The viability of cells cultured with Tonalide for 20 h after treatment at 42˚C was reduced to nearly half of that at 37˚C, and to 10% of the control after culture for 72 h. These values for the reduction of cell viability were also acheived by the Trypan blue dye-exclusion assay. The lifespan-prolonging effects of Tonalide on mice implanted with EAT cells were also examined. The lifespan of mice administrated 1.8 mg/day of Tonalide was prolonged by up to 28 days, while mice that did not receive Tonalide died within a mean of 15 days. Thus, Tonalide exhibited marked carcinostatic effects in vitro and in vivo and may prove to be a potent multipurpose antitumor agent in combination with hyperthermia.

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Evaluation of Measured and Predicted Environmental Concentrations of Selected Human Pharmaceuticals and Personal Care Products (10 pp)

Cited by 75 publications

References 45 publications

Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

A farewell to Dr Thomas Knacker (* 29.04.1951 – † 30.10.2011): scientific contributions and personal memories

The antitumor activities of the structurally-similar two-species aromatics Tonalide and Pearlide and the enhancement of their effects by hyperthermia

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