Evaluation of MDA and serum minerals in patients with overt and subclinical hypothyroidism

Abstract

Hypothyroidism is a common disorder of the thyroid gland in which the gland cannot compete with the body requirement of the thyroid hormones, triiodothyronine (T3) and thyroxine (T4). Hypothyroidism is classified into overt (OH) and subclinical (SbH), in which the first comprises the cases that have elevated levels of thyroid- stimulating hormone (TSH) and reduced levels of T4 while the second comprises the cases with elevated TSH but normal T4 levels. The goal of the present study is to investigate the level of malondialdehyde (MDA) and some minerals (calcium, magnesium, and phosphorus) in patients with SbH and OH. For this purpose, 80 patients from Al-Yarmook Teaching Hospital were enrolled in the study half of them were diagnosed with OH and the other half were diagnosed with SbH. The study has been controlled with 40 healthy people of comparable age and all of the three groups were contained 50% males and females. The anthropometric examination of subjects has revealed that the body mass index (BMI) and waist to hip ratio (WHpR) were significantly (p<0.05) altered among control, OH, and SbH subjects.