Evaluation of Mast Cell Distribution in Oral Lichen Planus and Lichenoid Lesions by Immunohistochemical and Histochemical Analysis

Balcı, Mahi; Erçin, Mustafa Emre

doi:10.3844/ajisp.2016.99.106

Cited by 3 publications

(15 citation statements)

References 20 publications

(28 reference statements)

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“…Juneja et al had reported that there was an increase in the mast cell numbers at sites of epithelial disruption in both OLP and OLR groups with significantly higher numbers ( P < .05) in OLP than OLR.…”

Section: Resultsmentioning

confidence: 96%

“…All 12 studies had answered the 1st research question of the mast cell number in OLP patients. 5 studies had used toluidine blue‐based staining to count the number of the mast cells.…”

Section: Resultsmentioning

confidence: 99%

“…1 study had qualitatively stated that there is an increase in mast cell density and had not reported on the absolute numbers. 5 studies had compared the mast cell numbers with OLR, 2 studies had reported that there is an increase in the mast cells in OLR compared with OLP, 2 studies had reported that the mast cell numbers were higher in OLP and 1 study reported no significant difference . 1 study had compared the mast cell numbers with OLR and squamous cell carcinoma and stated that the mast cell numbers were highest in OLP.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 6 studies addressed the localization of mast cells in OLP. 3 studies had divided the zones below the epithelium based on metric measurements and had reported on the mast cell numbers. 1 study by Santosh Reddy et al had reported the mast cell count in the subepithelial zone and deeper connective tissue.…”

Section: Resultsmentioning

confidence: 99%

“…We observed that the authors had not mentioned the exact method of localization of the zones. The study by Juneja et al had analyzed the mast cells in areas of epithelial ulceration and intact zones.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Mast cell expression in oral lichen planus: A systematic review

Vadivel

Govindarajan²,

Somasundaram

et al. 2019

J of Invest & Clin Dent

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Lichen planus is a common chronic, inflammatory, immune‐mediated mucocutaneous disorder affecting the skin and mucosa. The role of mast cells in the genesis of lichen planus has been debated. Establishing a definitive part played by mast cells and its degranulation would possibly provide a permanent, cost‐effective treatment modality for oral lichen planus (OLP). This review aims to study the expression of mast cells qualitatively and quantitatively in OLP. The research questions were framed to assess the mast cell count, localization within the epithelium basement membrane zone and degranulation of mast cells. We performed a systematic search of PubMed, Medline, Cochrane and Web of Science. We found a total of 120 studies from which 12 were found suitable for the review. There is a marked increase in the number of mast cells in OLP. The mast cells were seen in increased numbers in the epithelial and connective tissue junction at areas of basement membrane disruption. There was also an increase in the degranulation of mast cells. It is evident that there is an increase in the mast cell number in lichen planus and its subsequent degranulation.

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Section: Resultsmentioning

confidence: 96%

“…All 12 studies had answered the 1st research question of the mast cell number in OLP patients. 5 studies had used toluidine blue‐based staining to count the number of the mast cells.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Mast cell expression in oral lichen planus: A systematic review

Vadivel

Govindarajan²,

Somasundaram

et al. 2019

J of Invest & Clin Dent

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Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Agha‐Hosseini

Samami

Tavakol

et al. 2019

J Islam Dent Assoc Iran

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Background and Aim: Oral lichen planus (OLP) is a chronic, inflammatory, T-cellmediated autoimmune oral mucosal disease. Oral lichenoid lesions develop as a type IV hypersensitivity reaction. Both of these entities are potential precancerous conditions; this adds to their clinical significance. The purpose of this literature review was to detect the similarities and the differences of these lesions to enhance the information of colleagues in managing these groups of patients. Materials and Methods: For this review, we searched Cochrane, Medline, and Embase databases from January 1990 to the end of October 2018. A total of 96 published papers, including review papers, case reports, cohort studies, case-control studies, and meta-analysis studies, were included and analyzed. Results: OLP and oral lichenoid reactions are two distinct diseases. They can be clinically similar but they have different etiologic factors. A histopathological study is necessary to differentiate them. Conclusion: The definitive diagnosis of these conditions is extremely important given their potentially premalignant nature. A timely diagnosis probably results in proper management. Based on the present research, the final differentiation between OLP and oral Lichenoid reactions relies on both clinical and histopathological manifestations according to the modified World Health Organization (WHO) criteria.

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Evaluation of mast cell count in oral and cutaneous lichen planus lesions

et al. 2021

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Introduction: Lichen planus (LP) is a relatively common chronic mucocutaneous disorder diagnosed based on clinical manifestations and histopathological findings. Mast cells (MCs) are multifunctional immune cells that are involved in the pathogenesis of LP by releasing certain chemical mediators. Objectives: The purpose of this comparative study was to estimate the number of intact (granulated), degranulated and total MCs in oral lichen planus (OLP) and cutaneous lichen planus (CLP) lesions. Patients and Methods: The present descriptive-analytical and cross-sectional study was conducted on 125 LP blocks, including 40 OLP samples and 85 CLP samples. The mean number of granulated, degranulated and total MCs were counted under light microscope (×100 and ×400). Data were analyzed by SPSS version 24 software using Mann-Whitney U and Pearson’s chi-square tests. Results: The mean total MC count was 14.92 ± 3.90 in OLP samples and 14.04 ± 5.60 in CLP samples respectively which was not statistically significant. The mean granulated MC count in CLP (10.53 ± 5.70) was higher than in OLP (4.34 ± 3.46) (P<0.001). The mean degranulated MC count in OLP (10.57 ± 2.99) was higher than in CLP (3.51 ± 2.72) (P<0.001). Conclusion: No statistically significant difference was observed in the total MC count between OLP and CLP; however the difference in the degranulated MC count was detected between OLP and CLP. Despite the homogeneity in the total MC count, the MCs appear to play different pathological roles in OLP and CLP.

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Evaluation of Mast Cell Distribution in Oral Lichen Planus and Lichenoid Lesions by Immunohistochemical and Histochemical Analysis

Cited by 3 publications

References 20 publications

Mast cell expression in oral lichen planus: A systematic review

Mast cell expression in oral lichen planus: A systematic review

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Evaluation of mast cell count in oral and cutaneous lichen planus lesions

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