Evaluation of marine brown algae Sargassum ilicifolium extract for analgesic and anti-inflammatory activity

Simpi, Chandraraj C; Nagathan, Channabasappa V; Karajgi, Santosh; Kalyane, Navanath V.

doi:10.4103/0974-8490.112413

Cited by 21 publications

(11 citation statements)

References 4 publications

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“…Seaweed polysaccharides have various biological activities, including anti-inflammation (Coura et al, 2012;Jung, Jin, Ahn, Lee, & Choi, 2013;Simpi, Nagathan, Karajgi, & Kalyane, 2013). NO is an inflammatory mediator induced by inflammatory cytokines or bacterial LPS in various cell types including macrophages (Swindle & Metcalfe, 2007).…”

Section: Effect Of the Seaweed Polysaccharides On No Secretionmentioning

confidence: 99%

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

et al. 2016

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Section: Effect Of the Seaweed Polysaccharides On No Secretionmentioning

confidence: 99%

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

et al. 2016

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“…This study found that the content of flavonoids in algae can reduce pain by reducing prostaglandins [7]. Another study by Simpi et al found that Sargassum ilicifolium is able to relieve pain by producing acetic acid which allows seaweed to produce its analgesic activity both peripherally and centrally [5].…”

Section: Discussionmentioning

confidence: 99%

“…This marine algae has been considered safe, non-toxic, easy to find, and its availability is not limited to various fields [3,4]. A number of pharmacological activities have been reported on marine algae, for example, antitumor, cytotoxic antioxidants, anthelmintic, anticoagulant, antibacterial, antifungal, hepatoprotective effect, and inhibiting DNA polymerase and xanthine oxidase [4,5]. A study by Hong et al using Sargassum fulvellum and Sargassum thunbergii indicated the presence of antipyretic, analgesic, and anti-inflammatory activity in mice [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Total Flavonoid Levels in Brown Algae (Sargassum Sp. And Padina Sp.) as Analgesic Drug Therapy

Ruslin

Husain

et al. 2018

Asian J Pharm Clin Res

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Objective: Brown algae is one of the most interesting phyla that consist of pharmacologically active compounds and have been widely studied in recent years. One of the active compounds contained in brown algae that are known to have an analgesic effect is flavonoids. The aim of this study is to analyze the total amount of flavonoid compound in Sargassum sp. and Padina sp. as an analgesic drug.Methods: Samples used in this study were brown algae Sargassum sp. and Padina sp. taken from the Punaga Ocean, Takalar, South Sulawesi. The samples were extracted using the maceration method. After the extraction procedure, the total flavonoid levels were measured using a quercetin standard curve at maximum frequency.Results: Based on the measurement results, the total flavonoid levels in Sargassum sp. are 1.428%±sSD 0.168%.Conclusion: Padina sp. has higher total flavonoid levels compared to Sargassum sp. and can potentially act as an analgesic drug.

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“…Penelitian terhadap fukoidan yang berasal dari Undaria pinnatifi da (Harvey) Suringar pada model tikus radang yang diinduksi karagenan secara in vivo menunjukkan penghambatan inflamasi sebesar 68,19% (6) . Ekstrak methanol Sargassum ilicifolium dengan dosis 50-100 mg/kg secara in vivo memilliki aktivitas antiinfl amasi melalui mekanisme menghambat pembentukan edema pada tikus yang diinduksi karagenan (7) .…”

Section: Pendahuluanunclassified

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida

Werawati¹,

Mumpuni²,

Kusmardi³

et al. 2019

jifi

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Inflamasi adalah respon jaringan pembuluh darah terhadap infeksi dan jaringan yang rusak untuk menghilangkan penyebab inflamasi. Tapi dalam beberapa kondisi, inflamasi dapat menyebabkan timbulnya penyakit kronis, seperti aterosklerosis. Adesi leukosit ke endotelium vaskular merupakan ciri proses inflamasi Adanya molekul adesi, seperti ICAM-1dan VCAM-1 yang meningkat dapat menyebabkan adesi monosit dan limfosit pada sel endotel melalui ikatan molekul adesi pada sel endotel. Crude fukoidan berasal dari Sargassum crassifolium yang diambil dari perairan Garut dan diekstraksi dengan HCl encer, diuji aktivitas antiinflamasi melalui penghambatan kadar ICAM-1 dan VCAM-1 menggunakan model sel RAW 264.7 yang diinduksi inflamasi dengan lipopolisakarida. Uji viabilitas dilakukan dengan metode MTT pada rentang konsentrasi 0,49-1000 µg/mL. Pola penghambatan proliferasi sel dipengaruhi oleh konsentrasi. Dari uji viabilitas didapat konsentrasi tertinggi yang menyebabkan viabilitas sel sebesar 80% adalah konsentrasi crude fukoidan 86,46 μg/ml. Crude fukoidan terbukti dapat menurunkan kadar ICAM-1 dan VCAM-1 pada konsentrasi 50 dan 25 μg/ml. Persen penghambatan kadar ICAM pada konsentrasi 50 µg/mL adalah 61,04% dibanding kontrol inflamasi dan 74,26% pada konsentrasi 25 µg/mL. Sementara persen penghamabatan kadar VCAM-1 pada konsentrasi 50 µg/mL adalah74,76% dibanding kontrol inflamasi dan 79,94% pada konsentrasi 25 µg/mL.

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Evaluation of marine brown algae Sargassum ilicifolium extract for analgesic and anti-inflammatory activity

Cited by 21 publications

References 4 publications

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

Analysis of Total Flavonoid Levels in Brown Algae (Sargassum Sp. And Padina Sp.) as Analgesic Drug Therapy

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida

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