Evaluation of Maltose-Based Cationic Liposomes with Different Hydrophobic Tails for Plasmid DNA Delivery

Li, Bo; Deng, Liangliang; Zeng, Youlin

doi:10.3390/molecules22030406

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…Thus, maltose‐based cationic liposomes with different hydrophobic chain lengths have been developed recently to reduce cytotoxicity and improve delivery outcomes. [ 79 ]…”

Section: Macroengineered Intracellular Deliverymentioning

confidence: 99%

A Comprehensive Review on Intracellular Delivery

Rad

Bazaz

et al. 2021

Advanced Materials

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Intracellular delivery is considered an indispensable process for various studies, ranging from medical applications (cell‐based therapy) to fundamental (genome‐editing) and industrial (biomanufacture) approaches. Conventional macroscale delivery systems critically suffer from such issues as low cell viability, cytotoxicity, and inconsistent material delivery, which have opened up an interest in the development of more efficient intracellular delivery systems. In line with the advances in microfluidics and nanotechnology, intracellular delivery based on micro‐ and nanoengineered platforms has progressed rapidly and held great promises owing to their unique features. These approaches have been advanced to introduce a smorgasbord of diverse cargoes into various cell types with the maximum efficiency and the highest precision. This review differentiates macro‐, micro‐, and nanoengineered approaches for intracellular delivery. The macroengineered delivery platforms are first summarized and then each method is categorized based on whether it employs a carrier‐ or membrane‐disruption‐mediated mechanism to load cargoes inside the cells. Second, particular emphasis is placed on the micro‐ and nanoengineered advances in the delivery of biomolecules inside the cells. Furthermore, the applications and challenges of the established and emerging delivery approaches are summarized. The topic is concluded by evaluating the future perspective of intracellular delivery toward the micro‐ and nanoengineered approaches.

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“…Thus, maltose‐based cationic liposomes with different hydrophobic chain lengths have been developed recently to reduce cytotoxicity and improve delivery outcomes. [ 79 ]…”

Section: Macroengineered Intracellular Deliverymentioning

confidence: 99%

A Comprehensive Review on Intracellular Delivery

Rad

Bazaz

et al. 2021

Advanced Materials

View full text Add to dashboard Cite

show abstract

Liposomes vs Phytosomes: Principles, Methodologies, and Therapeutic Applications with Emphasis on CNS Disorders

Ahmad

Arya

Agrawal

et al. 2020

Nanopharmaceuticals: Principles and Applications Vol. 1

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Arginine modification of lycosin-I to improve inhibitory activity against cancer cells

Zhang

Yan

et al. 2017

Org. Biomol. Chem.

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Lycosin-I is a linear amphipathic α-helical anticancer peptide (ACP) extracted from the spider Lycosa singoriensis, which can activate the mitochondrial death pathway to induce apoptosis in tumor cells and up-regulate p27 to inhibit cell proliferation. However, the applicability of lycosin-I as a novel anticancer drug is limited by its low cellular entry and efficacy in solid tumors. Amino acid substitution presents an effective and modest strategy to improve the anticancer activity and bioavailability of ACPs. Herein, an arginine-modified lycosin-I (named R-lycosin-I) was designed and synthesized by substituting lysine (Lys) with arginine (Arg). This peptide exhibited higher anticancer activity and penetrability against solid tumor cells than lycosin-I. They displayed noticeable differences in their physicochemical properties including the secondary structure, hydrodynamic size, and zeta potential. Fluorescence analyses have confirmed that R-lycosin-I exhibits increased cellular uptake and improved intracellular distribution. Due to its superior physical and chemical properties and high serum stability, R-lycosin-I could penetrate deeply into tumor spheroids and produce strong toxicity in the 3D tumor model. Overall, these findings suggest that arginine modification may provide an effective strategy for improving the anticancer activity of lycosin-I, and R-lycosin-I may be a useful lead for developing anticancer drugs.

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Evaluation of Maltose-Based Cationic Liposomes with Different Hydrophobic Tails for Plasmid DNA Delivery

Cited by 3 publications

References 50 publications

A Comprehensive Review on Intracellular Delivery

A Comprehensive Review on Intracellular Delivery

Liposomes vs Phytosomes: Principles, Methodologies, and Therapeutic Applications with Emphasis on CNS Disorders

Arginine modification of lycosin-I to improve inhibitory activity against cancer cells

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