Evaluation of macrolinguistic aspects of the oral discourse in patients with Alzheimer’s disease

Lira, Juliana Onofre de; Minett, Thaı́s; Bertolucci, Paulo Henrique Ferreira; Ortiz, Karin Zazo

doi:10.1017/s1041610218001758

Cited by 10 publications

(14 citation statements)

References 30 publications

(78 reference statements)

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“…Memory impairment typical in AD contributes to many of these dysfunctions. For example, word retrieval difficulties may be the earliest signs of AD, 10 manifesting in changes in several language aspects, such as verbal naming, 11 speech content density and quantity, 12 accurate meaning communication, 4 pausation, and speech tempo. 13 , 14 Word retrieval is often tested using picture description tasks 15 where the participants are instructed to describe what they see in a picture.…”

Section: Introductionmentioning

confidence: 99%

A systematic literature review of automatic Alzheimer’s disease detection from speech and language

Petti

Baker

Korhonen

2020

Journal of the American Medical Informatics Association

111

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Objective In recent years numerous studies have achieved promising results in Alzheimer’s Disease (AD) detection using automatic language processing. We systematically review these articles to understand the effectiveness of this approach, identify any issues and report the main findings that can guide further research. Materials and Methods We searched PubMed, Ovid, and Web of Science for articles published in English between 2013 and 2019. We performed a systematic literature review to answer 5 key questions: (1) What were the characteristics of participant groups? (2) What language data were collected? (3) What features of speech and language were the most informative? (4) What methods were used to classify between groups? (5) What classification performance was achieved? Results and Discussion We identified 33 eligible studies and 5 main findings: participants’ demographic variables (especially age ) were often unbalanced between AD and control group; spontaneous speech data were collected most often; informative language features were related to word retrieval and semantic, syntactic, and acoustic impairment; neural nets, support vector machines, and decision trees performed well in AD detection, and support vector machines and decision trees performed well in decline detection; and average classification accuracy was 89% in AD and 82% in mild cognitive impairment detection versus healthy control groups. Conclusion The systematic literature review supported the argument that language and speech could successfully be used to detect dementia automatically. Future studies should aim for larger and more balanced datasets, combine data collection methods and the type of information analyzed, focus on the early stages of the disease, and report performance using standardized metrics.

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Section: Introductionmentioning

confidence: 99%

A systematic literature review of automatic Alzheimer’s disease detection from speech and language

Petti

Baker

Korhonen

2020

Journal of the American Medical Informatics Association

111

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“…We can expect a loss of the macro-linguistic dimension of the Discourse in cases of dementia, affecting both aspects of the macrostructure and the microstructure discoursive. (11,12) In the reassessment, we observed a considerable improvement in the patient's performance regarding the number of words and units of information (table 1). The improvement of the microstructure of the speech (number of words) was accompanied by the improvement of one aspect of the macrostructure, the production of a greater number of main information units.…”

Section: Performance On the Formal Testsmentioning

confidence: 89%

“…Since there are no criteria for the classification of normality for the elements of discourse analysis, with consensus in the literature, we used the Oral Discourse Evaluation Index in Patients with Alzheimer's Disease (AD) proposed by Lira (11,12) . The index was developed to more effectively assess language through discourse in AD, using the least possible variables, which can better identify the change in performance.…”

Section: Case Presentationmentioning

confidence: 99%

A efetividade da terapia fonoaudiológica no nível discursivo: estudo de caso de distúrbio linguístico-cognitivo na demência.

Marquete

Chaves

Barreto

2021

CoDAS

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RESUMO Pessoas com demência apresentam alterações cognitivas, de linguagem e de comportamento. As alterações da linguagem podem ser identificadas no discurso desses pacientes já nas fases iniciais. Contudo, ainda há poucas pesquisas sobre a efetividade da terapia fonoaudiológica nesses casos. Os objetivos deste estudo foram descrever as manifestações linguísticas presentes no discurso de um paciente com distúrbio linguístico-cognitivo e analisar a efetividade da terapia fonoaudiólogica. Foi realizado um estudo de caso único longitudinal, com participante com demência mista em fase leve à moderada, submetida à avaliação pré e pós-terapia fonoaudiológica. Foram utilizados os subtestes de Compreensão oral e de Discurso narrativo oral da Bateria MTL-Brasil e o teste The Dog Story. Na avaliação, a paciente apresentou alteração grave da compreensão oral e alteração nas dimensões micro e macrolinguística do discurso, obtendo pontuação 2/10 no índice de avaliação do discurso oral. Após a terapia, a paciente obteve resultados dentro do esperado nos subtestes de Compreensão oral (palavras, frases e texto) e de Discurso narrativo oral (número de palavras e unidades de informação) da Bateria MTL-Brasil. No teste The Dog Story, a participante obteve melhor desempenho na produção do discurso em relação aos itens alteração lexical e complexidade sintática (dimensão microlinguística) e macroproposição (dimensão macrolinguística), alcançando escore de 5/10 no índice. É possível afirmar que a terapia fonoaudiológica foi efetiva a curto prazo para esta paciente com distúrbio linguístico-cognitivo e alterações no nível discursivo da linguagem.

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“…Concerns over language impairments in AD are not new. Many studies have sought to identify impairments at different levels of linguistic processing, like phonetic 3 , phonological 4 , lexical-semantic 5 and syntactic 6 , along with deficits in discourse 7 . These studies have shown that language abilities become differentially impaired as the disease progresses.…”

Section: Introductionmentioning

confidence: 99%

Language impairment in the moderate stage of dementia due to Alzheimer's disease

Ortiz

Lira

Minett

et al. 2021

Arq. Neuro-Psiquiatr.

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Background: During the moderate stage of dementia due to Alzheimer’s disease (AD), language disorder is more evident and it impacts on communication. An overview of language impairment could be helpful to find compensatory communication strategies for these patients. Objective: To identify all language impairments among patients with moderate-stage of AD. Methods: 20 patients diagnosed with probable AD based on the criteria of the NINCDS-ARDRA, with a MMSE score of 13-23 points and CDR=2, who were undergoing treatment for AD with therapeutic doses of acetyl cholinesterase inhibitors, were assessed using the Boston Diagnostic Aphasia Examination (BDAE), a test that provides a broad assessment of language. The results were compared with the performance of a normal population. Results: The patients assessed in this study presented normal scores for oral and written word recognition, repetition, mechanics of writing, primer-level dictation and spelling to dictation but also had impairment at most levels of linguistic processing, in oral and written comprehension and production. In general, as expected, the tasks relying on access to the mental lexicon were most significantly affected. However, they performed well in the naming task, in which semantic cues were presented. Moreover, the patients assessed in this study had better performance in written comprehension tasks than in oral ones. Conclusion: The severity of the language impairments was not homogenous, with some linguistic abilities more impaired than others. The abilities that were found to be preserved can help to guide strategies for aiding in communication at this stage of AD.

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Evaluation of macrolinguistic aspects of the oral discourse in patients with Alzheimer’s disease

Cited by 10 publications

References 30 publications

A systematic literature review of automatic Alzheimer’s disease detection from speech and language

A systematic literature review of automatic Alzheimer’s disease detection from speech and language

A efetividade da terapia fonoaudiológica no nível discursivo: estudo de caso de distúrbio linguístico-cognitivo na demência.

Language impairment in the moderate stage of dementia due to Alzheimer's disease

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