Evaluation of Lymphocyte Subgroups in Children With Down Syndrome

Yılmaz, Cahide; Doğan, Murat; Başarslan, Fatmagül; Yılmaz, Nebi; Yuca, Sevil Arı; Bulan, Keziban; Kaya, Avni; Çaksen, Hüseyîn

doi:10.1177/1076029613511521

Cited by 2 publications

(3 citation statements)

References 13 publications

(22 reference statements)

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“…This is in agreement with a study from the Netherlands in which CD4 + invariant NK T cells, CD4 + T lymphocytes, and CD4 + CD25 high T cells were significantly decreased in DS children compared to their siblings [23]. Moreover, a more recent study reported that levels of CD4, CD19, and CD3 were significantly lower in a DS group (85 patients and 64 controls, p < 0.05) [30]. On the other hand, Cetiner et al [31] found higher values of CD4 in DS patients.…”

Section: Discussionsupporting

confidence: 91%

“…Our finding is similar to Seckin et al [21], who studied B lymphocyte dysfunction in 39 DS patients and 37 healthy children and found a significant decrease in CD19 in DS (1061 ±195 vs. 1594 ±410, p = 0.001). A reduced number of B lymphocytes has also been shown in DS in several studies [30, 32, 33]. These studies were carried out in DS children above the age of six years.…”

Section: Discussionmentioning

confidence: 85%

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Lymphocyte subgroups and recurrent infections in children with Down syndrome – a prospective case control study

Mitwalli¹,

Wahba²,

Shaltout³

et al. 2018

cejoi

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Down syndrome (DS) is the commonest genetic disorder and more liable for recurrent infections. We aimed to determine the differences in lymphocyte subgroups between DS children and the healthy population and to study the pattern and likelihood for recurrent infections and hospital admission due to infection. Our study was carried out in the Genetic Unit of Mansoura University Children’s Hospital, Egypt. The study enrolled 150 DS (DS group) and 100 controls (CG group). They were assessed for recurrent infections (including tonsillitis, otitis media [OM], pneumonia, upper respiratory tract infections [URTI], sinusitis, and gastroenteritis [GE]) and hospital admission due to infections. All patients were subjected to complete blood count and flow cytometric analysis for expression markers of B lymphocytes (CD19), natural killer (NK) cells (CD56), and T lymphocytes (CD3, CD4 and CD8). We found a statistically significant increase in the frequency of URTIs and sinusitis, OM, pneumonia, and hospital admission in the DS group. As regards the type of recurrent infection in DS, it was highest for URTIs and sinusitis. For age groups below 13 years, a statistically significant decrease in all studied CD markers was found in the DS group, while for the 13-18-year-olds, a statistically significant decrease was found in CD4, CD19, and CD56 in the DS group. Non-significant correlations were found between CD markers and recurrent infection and hospital admission. We concluded that lymphocyte subgroups that carry CD3, CD4, CD8, CD19, and CD56 were decreased in DS. Recurrent infections and hospital admission are still striking feature for DS but are not significantly correlated with lymphocyte subgroups.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 85%

Lymphocyte subgroups and recurrent infections in children with Down syndrome – a prospective case control study

Mitwalli¹,

Wahba²,

Shaltout³

et al. 2018

cejoi

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“…Os números de células T, B e natural killer (NK) circulantes estão reduzidos em pessoas com SD, e sua resposta a mitógenos é ineficiente [12]. Além disso, esses pacientes podem apresentar níveis diminuídos de linfócitos T CD4+ e níveis elevados de linfócitos T CD8+ comparados com indivíduos saudáveis, apresentando alteração na taxa CD4+/CD8+.…”

Section: Introductionunclassified

Avaliação da migração de neutrófilos e da frequência relativa de linfócitos CD4+/CD8+ em crianças com síndrome de Down e controles

Filho

Klein

Tavares

et al. 2015

Sci Med

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Este artigo é resultante da Dissertação apresentada pelo autor Artur Kautzmann Filho ao Programa de Pós-Graduação em Pediatria e Saúde da ABSTRACT Aims:To evaluate neutrophil migration and the relative frequency of CD4+/CD8+ lymphocytes in children with Down syndrome and in healthy controls. Methods: This was a case-control study carried out at the Institute of Biomedical Research, affiliated with São Lucas Hospital of the Pontifical Catholic University of Rio Grande do Sul (PUCRS). Patients with Down syndrome were selected by convenience sampling, including all children with Down syndrome aged 3 to 13 years treated at the Pediatric and Otolaryngology Outpatient Clinics of São Lucas Hospital and at KinderCenter for Children with Special Needs, in Porto Alegre, State of Rio Grande do Sul, Brazil, between January and December 2012. Healthy children without Down syndrome, participants in another ongoing study conducted by Institute of Biomedical Research, were recruited to the control group. Those patients with the largest volume of cells stored in cryotubes were selected. A neutrophil chemotaxis assay and immunophenotyping of CD4+ and CD8+ T cells were performed to evaluate the functionality of the immune response. Associations were assessed by the chi-squared test, Student's t test, or Mann-Whitney's test. All tests were bidirectional, and p values less than 0.05 were regarded as statistically significant. Results: This study included 19 patients (13 with Down syndrome and six controls), with a mean age of 8.13 and 9.83 years, respectively. No significant changes concerning neutrophil migration were observed in the Down syndrome group. However, patients with Down syndrome tended to have a lower rate of CD4+ T cells and a higher rate of CD8+ T cells. The CD4+/CD8+ ratio revealed significant difference between the groups, being lower in patients with Down syndrome. Conclusions: This study suggests that patients with Down syndrome show a decreased CD4+/CD8+ ratio, which may contribute to the frequent and recurrent infections in these children.KEY WORDS: down syndrome; immunity; CD4-CD8 ratio; child; infection. Scientia Medica Artigo originAlOpen Access 2015;25(1):ID19235 ISSN 1980ISSN -6108 : http://dx.doi.org/10.15448/1980ISSN -6108.2015 Recebido: novembro,

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Evaluation of Lymphocyte Subgroups in Children With Down Syndrome

Cited by 2 publications

References 13 publications

Lymphocyte subgroups and recurrent infections in children with Down syndrome – a prospective case control study

Lymphocyte subgroups and recurrent infections in children with Down syndrome – a prospective case control study

Avaliação da migração de neutrófilos e da frequência relativa de linfócitos CD4+/CD8+ em crianças com síndrome de Down e controles

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