Evaluation of Low Blood Lead Levels and Its Association with Oxidative Stress in Pregnant Anemic Women: A Comparative Prospective Study

Tiwari, Amit; Mahdi, Abbas Ali; Zahra, Fatima; Sharma, Sudarshna; Negi, Mahendra Pal Singh

doi:10.1007/s12291-012-0202-2

Cited by 17 publications

(12 citation statements)

References 39 publications

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“…Ugwuja and co-workers reported negative association between BLL and hemoglobin concentrations among pregnant women in Abakaliki, Nigeria (45). In line with that, some studies have reported negative association between BLL and hemoglobin concentrations (79). Lead has been shown to inhibit heme synthesis by altering the activities of δ-amino levulinic acid dehydratase [ALAD] thereby inducing microcytic and hypochromic anemia (79, 85).…”

Section: Discussionsupporting

confidence: 63%

“…In line with that, some studies have reported negative association between BLL and hemoglobin concentrations (79). Lead has been shown to inhibit heme synthesis by altering the activities of δ-amino levulinic acid dehydratase [ALAD] thereby inducing microcytic and hypochromic anemia (79, 85). However, the reported associations between BLL and health outcomes in some of the studies (30, 45, 46) should be interpreted with care as these are cross-sectional studies and therefore were not subjected to certain statistical measures of association.…”

Section: Discussionsupporting

confidence: 63%

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Blood Lead Levels in Women of Child-Bearing Age in Sub-Saharan Africa: A Systematic Review

Bede-Ojimadu

Amadi

Orisakwe

2018

Front. Public Health

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This paper reported available studies on blood lead level of childbearing age in Sub-Saharan African women. PubMed and Google scholar databases were searched for original articles reporting blood lead levels of women of childbearing age in Sub-Saharan Africa. Searches were not limited to year of study but limited to studies published in English Language. Data were extracted and synthesized by estimating the weighted mean of the reported blood lead levels. Fifteen papers fulfilled the inclusion criteria. Mean blood lead levels of women in the studies ranged from 0.83 to 99 μg/dl. The overall weighted mean of blood lead levels was 24.73 μg/dl. The weighted mean from analyses of data on blood lead levels of pregnant women alone was 26.24 μg/dl. Identified sources of lead exposure included lead mine, informal lead-acid battery recycling, leaded gasoline and piped water. Elevated BLLs were associated with incidence of preeclampsia, hypertension, and malaria. Important contributing factors for elevated blood lead levels (BLL) in these women include poverty, high environmental lead burden, low awareness on lead exposure hazards and lack of regulation for lead in consumer products. BLLs of women of childbearing age in SSA are unacceptably high. There is need therefore, for aggressive programs to address lead exposure in this population.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 63%

Blood Lead Levels in Women of Child-Bearing Age in Sub-Saharan Africa: A Systematic Review

Bede-Ojimadu

Amadi

Orisakwe

2018

Front. Public Health

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“…In addition, O & NS processes could play a role in pathophysiological underpinnings of perinatal depression, including immune activation, inflammation and lowered T3 PUFA levels (Moylan et al, 2014). The erythron, including erythrocyte morphology, is in part modulated by increased oxidative stress and reduced levels of antioxidants (Lurie and Mamet, 2000;Peng and Pan, 2017;Tiwari et al, 2012;Waggiallah and Alzohairy, 2011).…”

Section: Introductionmentioning

confidence: 99%

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Roomruangwong

Barbosa

Matsumoto

et al. 2017

Journal of Affective Disorders

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“…There are numbers of studies published in developing countries that have estimated the effect of trace elements levels on maternal and umbilical cord blood. In Iraq very few studies were published covering population [22][23][24][25] In previous studies different concentrations of trace elements such as uranium (U), Lead (Pb) and iron (Fe) have been found in maternal blood and umbilical cord, showing a conflicting cohort with the anthropometric characteristics of the infants [26][27][28][29][30][31][32][33][34][35] Several factors may participate to the contradiction in those results from previous studies, such as diversity of the study designs and techniques used, heterogeneity in populations and among others.…”

Section: Introductionmentioning

confidence: 99%

Trace of heavy metals in maternal and umbilical cord blood samples in association with birth outcomes in Baghdad, Iraq

et al. 2017

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Trace elements are essential nutritional components in humans and inconvenient tissue content that have a significant influence on infant size. The aim of this study is to evaluate the effects of concentration of elements (uranium (U), lead (Pb) and iron (Fe)) and absorption of Pb and Fe on maternal and umbilical cord blood samples. The concentration and absorption of Pb and Fe in blood samples were determined by using atomic absorption spectrophotometry device, while the uranium concentration was determined by using CR-39 detector. Fifty women of age 16-44 years are involved in this study. Results show that the maximum and minimum values of both concentration and absorption in the maternal samples were for Pb and Fe, respectively. In addition, for umbilical cord, the maximum values of concentration and absorption were for Fe and the minimum concentration and absorption were for U and Pb, respectively. A significant correlation between maternal and umbilical cord blood samples was found. This indicates that the Pb, U and Fe elements can easily transfer from maternal to the fetal body which impacts the growth of fetus.

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Evaluation of Low Blood Lead Levels and Its Association with Oxidative Stress in Pregnant Anemic Women: A Comparative Prospective Study

Cited by 17 publications

References 39 publications

Blood Lead Levels in Women of Child-Bearing Age in Sub-Saharan Africa: A Systematic Review

Blood Lead Levels in Women of Child-Bearing Age in Sub-Saharan Africa: A Systematic Review

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Trace of heavy metals in maternal and umbilical cord blood samples in association with birth outcomes in Baghdad, Iraq

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