Evaluation of Long-Term Visual Field Function in Patients Undergoing Glaucoma Drainage Device Implantation

Liu, Qian; Saifee, Murtaza; Yu, Yinxi; Ying, Gui Shuang; Li, Shuning; Zhong, Hua; Gedde, Steven J.; Han, Ying

doi:10.1016/j.ajo.2020.03.025

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Additionally, this platform can potentially be used in conjunction with other analysis platforms such as the R package visualField (an open source module for analysis of visual field data), with the appropriate software to interface the two systems ( 24 ). Our platform has been used in a published study on HVFs in glaucoma patients undergoing glaucoma tube shunt implantation ( 25 ). Other research teams have performed studies with large volumes of HVFs for metric analysis and machine learning using in-house extraction software ( 6 , 11 ); however, their script was not published and validation cannot be compared with ours.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Saifee

Liu

et al. 2021

Front. Med.

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Purpose: To introduce and validate hvf_extraction_script, an open-source software script for the automated extraction and structuring of metadata, value plot data, and percentile plot data from Humphrey visual field (HVF) report images.Methods: Validation was performed on 90 HVF reports over three different report layouts, including a total of 1,530 metadata fields, 15,536 value plot data points, and 10,210 percentile data points, between the computer script and four human extractors, compared against DICOM reference data. Computer extraction and human extraction were compared on extraction time as well as accuracy of extraction for metadata, value plot data, and percentile plot data.Results: Computer extraction required 4.9-8.9 s per report, compared to the 6.5-19 min required by human extractors, representing a more than 40-fold difference in extraction speed. Computer metadata extraction error rate varied from an aggregate 1.2-3.5%, compared to 0.2-9.2% for human metadata extraction across all layouts. Computer value data point extraction had an aggregate error rate of 0.9% for version 1, <0.01% in version 2, and 0.15% in version 3, compared to 0.8-9.2% aggregate error rate for human extraction. Computer percentile data point extraction similarly had very low error rates, with no errors occurring in version 1 and 2, and 0.06% error rate in version 3, compared to 0.06-12.2% error rate for human extraction.Conclusions: This study introduces and validates hvf_extraction_script, an open-source tool for fast, accurate, automated data extraction of HVF reports to facilitate analysis of large-volume HVF datasets, and demonstrates the value of image processing tools in facilitating faster and cheaper large-volume data extraction in research settings.

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Section: Discussionmentioning

confidence: 99%

Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Saifee

Liu

et al. 2021

Front. Med.

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“…When IOP can no longer be controlled with medications surgical intervention is required, which often is not a permanent solution [43]. It is, therefore, essential to develop novel drugs that modulate the metabolic processes of trabecular meshwork, ciliary body, and retinal cells.…”

Section: Discussionmentioning

confidence: 99%

“…Production in-creased by 158% whereas outflow increased by 342%, a net 185% increase in outflow. In the untreated eye both flow and outflow decreased from the pre-treatment values, which may be the result of diurnal fluctuations [42,43]. Eight hours after administration, IOP was 20% lower than 30 minutes after administration of a 0.5% suspension of tolbutamide and 24% lower after the administration of a 0.5% solution of sodium tolbutamide.…”

Section: Effect Of 05% Tolbutamide On Aqueous Humor Outflow Facilitymentioning

confidence: 94%

Tolbutamide Eye Drops Increase Aqueous Humor Outflow and Lower Intraocular Pressure: A Proof of Concept for Glaucoma Treatment

Thumann¹,

Sorgente²,

Kropp³

et al. 2021

J Ophthalmol Res

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Background: Glaucoma refers to a heterogeneous group of diseases characterized by retinal cell degeneration and optic nerve atrophy leading to blindness. Even though about 40% of patients have normal intraocular pressure (IOP), current treatment. focuses on lowering IOP. With time, current drugs become less effective, which has motivated the search for novel drugs.The objective was to establish whether modulators of ATPsensitive potassium channels influence IOP.

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“…The sector wise values were then calculated by averaging the pointwise values across each sector based on prior established sectorial mapping. 20 Each VF hemifield was divided into five subfields: central, paracentral, nasal, arcuate 1, and arcuate 2 ( Figure 1 ), as previously described. 20 For 30–2 VF test, only data for points falling within the 24–2 domain were collected.…”

Section: Methodsmentioning

confidence: 99%

“… 20 Each VF hemifield was divided into five subfields: central, paracentral, nasal, arcuate 1, and arcuate 2 ( Figure 1 ), as previously described. 20 For 30–2 VF test, only data for points falling within the 24–2 domain were collected. Analysis of VF defects was carried out based on the classification system proposed by the Ocular Hypertension Treatment study.…”

Section: Methodsmentioning

confidence: 99%

Clinical and Visual Field Outcomes Following Minimally Invasive Glaucoma Surgery Combined with Cataract Surgery

Turner¹,

Taha²,

Yonamine³

et al. 2022

OPTH

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Purpose To determine the change in Humphrey visual field and clinical parameters after minimally invasive glaucoma surgery combined with cataract surgery. Patients and Methods Patients undergoing minimally invasive glaucoma surgery combined with cataract surgery in a multicenter retrospective case series between 2013 and 2021 with reliable preoperative and 12 to 18 month postoperative visual field measurements were included. Devices included iStent, XEN, and Hydrus. Clinical parameters were compared with a generalized linear model with generalized estimating equations between preoperative and postoperative visits including best corrected visual acuity, intraocular pressure, number of glaucoma medications and visual fields. Visual field metrics included mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and Collaborative Initial Glaucoma Treatment Study (CIGTS) score of total deviation probability and pattern deviation probability. Results Forty-four eyes from 39 patients were included. During the follow up period, visual acuity improved from 0.23±0.17 to 0.10±0.14 logMAR (mean ± standard deviation, p <0.001), number of glaucoma medications was reduced from 2.68±1.06 to 1.46±1.32 ( p <0.001), and intraocular pressure decreased from 17.08±4.23 mmHg to 14.92±3.13 mmHg ( p =0.003). Differences across devices were negligible. The only significant difference was a greater reduction in number of glaucoma medications in the XEN group ( p <0.001). There were no significant changes in the global parameters of VFI, MD, PSD, or CIGTS. Conclusion Overall, minimally invasive glaucoma surgery combined with cataract surgery appears to be effective at stabilizing visual field function, reducing intraocular pressure, reducing number of glaucoma medications, and improving visual acuity over a 12 to 18 month follow-up period across MIGS devices.

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Evaluation of Long-Term Visual Field Function in Patients Undergoing Glaucoma Drainage Device Implantation

Cited by 9 publications

References 30 publications

Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Tolbutamide Eye Drops Increase Aqueous Humor Outflow and Lower Intraocular Pressure: A Proof of Concept for Glaucoma Treatment

Clinical and Visual Field Outcomes Following Minimally Invasive Glaucoma Surgery Combined with Cataract Surgery

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