Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Saifee, Murtaza; Wu, Jian; Liu, Yingna; Ma, Ping; Patlidanon, Jutima; Yu, Yinxi; Ying, Gui‐Shuang; Han, Ying

doi:10.3389/fmed.2021.625487

Cited by 8 publications

(7 citation statements)

References 18 publications

(23 reference statements)

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“…This suggests that the structure-function correlations noted in this study may be applicable to a broader group of patients than the previous studies with a more limited scope were able to demonstrate [ 5 – 7 , 10 – 15 ]. Furthermore, visual field parameters were extracted using a validated, open-sourced script [ 16 ], illustrating how this script can be applied for future structure-function studies.…”

Section: Discussionmentioning

confidence: 99%

“…Global indices such as the mean deviation (MD) and pattern standard deviation (PSD) were recorded. For specific sector analyses, pointwise total deviation (TDV), PSD, and mean sensitivity (MS) values were extracted using a validated, open-sourced script ( https://pypi.org/project/hvf-extraction-script/ ) [ 16 ]. The script was used to extract pointwise data from the Ophthalmic Perimetry Values (OPV) DICOM files obtained directly from the Humphrey Visual Field device and PACS system.…”

Section: Methodsmentioning

confidence: 99%

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A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma

Kong

Turner

Saifee

et al. 2022

Journal of Ophthalmology

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Purpose. To evaluate the correlation of optical coherence tomography angiography (OCTA) and spectral-domain optical coherence tomography (SD-OCT) with visual field for global and sector-based indices among glaucoma and glaucoma-suspected eyes. Patients and Methods. This is a retrospective study, and in total, 48 glaucoma eyes and 31 glaucoma suspect eyes were included. The correlation between visual field parameters and radial peripapillary capillary (RPC) vessel density via OCTA was compared to the correlation with retinal nerve fiber layer (RNFL) thickness via SD-OCT. The RPC vessel density and RNFL thickness were divided into eight sectors, which included the temporal upper, temporal lower, superotemporal, inferotemporal, superonasal, inferonasal, nasal upper, and nasal lower sectors. Pearson correlations with 95% confidence intervals were calculated with resampling, and correlations were compared with a Fisher Z transformation. Results. Both RPC vessel density (R = 0.63, 95% CI [0.24, 0.86]) and RNFL thickness (R = 0.49, 95% CI [0.23, 0.69]) were correlated with the mean deviation when comparing global indices of glaucoma patients. In glaucoma suspects, the correlations between the mean deviation and RPC vessel density (R = 0.21, 95% CI [−0.05, 0.49]) and RNFL thickness (R = 0.01, 95% CI [−0.35, 0.39]) were not significant. Glaucoma eyes had the highest correlation between the mean sensitivity and RPC vessel density and RNFL thickness for the superotemporal, superonasal, temporal upper, and inferotemporal sectors. Conclusion. Across a diverse population and heterogeneous glaucoma types, RPC vessel density measurements correlate with global and sector-wise visual field indices similar to RNFL thickness.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma

Kong

Turner

Saifee

et al. 2022

Journal of Ophthalmology

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“…24 In this analysis, the raw values of the patient’s retinal sensitivity at each of the HVF 24-2 predetermined points were extracted from pdf scans of the HVFs using a custom data extraction tool based around the Python 25 package ‘hvf extraction script’. 26 This script used Google’s Tesseract Optical Character Recognition 27 to distinguish text inside a digital image and return the relevant text into a useable format. Although the ‘hvf extraction script’ was not originally intended for use on scanned documents, we found that by cleaning the images before processing, we could obtain values for a majority of the retinal sensitivity points.…”

Section: Methodsmentioning

confidence: 99%

Is point wise analysis of the Humphrey visual field feasible as a primary outcome in idiopathic intracranial hypertension?

Mollan

Bodza

Mhéalóid

et al. 2022

Preprint

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Purpose Using the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) data, this study aimed to determine if point analysis of the Humphrey visual field (HVF) could be more informative than the perimetric mean deviation (PMD) as an IIH trial outcome measure. Methods IIH:WT was a randomized controlled trial that recruited 66 people with active IIH (mean (standard deviation) age 32 (7.8 years)). Event-based analysis using a pointwise analysis of the numerical sensitivity data was performed. The number of participants that would be eligible for analysis was calculated when the data were enriched to reflect a medically treated cohort defined as a PMD between -2dB to -7dB. Results The HVF 24-2 mean (standard deviation) PMD in the worse eye was -3.5 ( 1.1dB), (range, -2.0 to -6.4dB), and point sensitivity showed a preference for peripheral and blind spot locations. Those points between 0 and -10dB demonstrated negligible ability to improve compared with those between -10dB and -25dB. In evaluating feasibility for a medical intervention trial, 346 points were available for analysis between -10dB and -25dB bilaterally compared with 4123 in baseline sensitivities of 0 to -10dB. Conclusions Mildly affected baseline sensitivities were unlikely to show considerable change over 24 months. There were fewer points available for analysis and greater variability if moderately affected baseline points were chosen. If point analysis was used as an outcome measure in a medical intervention trial, the majority of points would not demonstrate clinically meaningful change, thus offering little advantage over PMD.

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“…For specific sector analyses, pointwise total deviation (TD), pattern deviation (PD), TD probability (TDP), and PD probability (PDP) values were extracted using a validated, open-sourced script ( https://pypi.org/project/hvf-extraction-script/ ). 19 The script was used to extract pointwise data from the Ophthalmic Perimetry Values (OPV) DICOM files obtained directly from the Humphrey Visual Field device or extracted JPEG files. The sector wise values were then calculated by averaging the pointwise values across each sector based on prior established sectorial mapping.…”

Section: Methodsmentioning

confidence: 99%

Clinical and Visual Field Outcomes Following Minimally Invasive Glaucoma Surgery Combined with Cataract Surgery

Turner¹,

Taha²,

Yonamine³

et al. 2022

OPTH

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Purpose To determine the change in Humphrey visual field and clinical parameters after minimally invasive glaucoma surgery combined with cataract surgery. Patients and Methods Patients undergoing minimally invasive glaucoma surgery combined with cataract surgery in a multicenter retrospective case series between 2013 and 2021 with reliable preoperative and 12 to 18 month postoperative visual field measurements were included. Devices included iStent, XEN, and Hydrus. Clinical parameters were compared with a generalized linear model with generalized estimating equations between preoperative and postoperative visits including best corrected visual acuity, intraocular pressure, number of glaucoma medications and visual fields. Visual field metrics included mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and Collaborative Initial Glaucoma Treatment Study (CIGTS) score of total deviation probability and pattern deviation probability. Results Forty-four eyes from 39 patients were included. During the follow up period, visual acuity improved from 0.23±0.17 to 0.10±0.14 logMAR (mean ± standard deviation, p <0.001), number of glaucoma medications was reduced from 2.68±1.06 to 1.46±1.32 ( p <0.001), and intraocular pressure decreased from 17.08±4.23 mmHg to 14.92±3.13 mmHg ( p =0.003). Differences across devices were negligible. The only significant difference was a greater reduction in number of glaucoma medications in the XEN group ( p <0.001). There were no significant changes in the global parameters of VFI, MD, PSD, or CIGTS. Conclusion Overall, minimally invasive glaucoma surgery combined with cataract surgery appears to be effective at stabilizing visual field function, reducing intraocular pressure, reducing number of glaucoma medications, and improving visual acuity over a 12 to 18 month follow-up period across MIGS devices.

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Development and Validation of Automated Visual Field Report Extraction Platform Using Computer Vision Tools

Cited by 8 publications

References 18 publications

A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma

A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma

Is point wise analysis of the Humphrey visual field feasible as a primary outcome in idiopathic intracranial hypertension?

Clinical and Visual Field Outcomes Following Minimally Invasive Glaucoma Surgery Combined with Cataract Surgery

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