Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Anas Qahtan Hamdi,; Entedhar R. Sarhat,; Nagham Hasan Ali,; Thuraia Rifaat Sarhat,

doi:10.37506/ijfmt.v15i2.14578

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The term "vitamin D" refers to a group of fat-soluble biomolecules synthesized in the skin through exposure to ultraviolet irradiation from the sun. Apart from its role in oral health, vitamin D is also closely associated with bone metabolism and skeletal integrity [41].…”

Section: Hormones and Vitaminsmentioning

confidence: 99%

Etiopathogenesis of Dental Caries

Barani-Sveçla,

Buleshkaj

2024

Dentistry

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Dental caries, as a pervasive and complex global health issue affecting individuals of all ages, is influenced by a multitude of factors. These factors encompass the interplay of demineralization and remineralization processes, dietary and oral hygiene practices, salivary composition and flow, tooth morphology, genetics, fluoride exposure, and environmental and socioeconomic variables. This chapter analyzes three categories of factors that cause dental caries, such as: general, local, and iatrogenic factors. Initially, the genetic predisposition, gender-related hormonal fluctuations, aging, immunological elements, pregnancy-related changes, chronic diseases, hormonal disorders, vitamin levels, and socioeconomic factors are included in general factors that contribute to the susceptibility to dental caries. Moreover, to understand and mitigate caries risk, it is pivotal to analyze local factors such as dental morphology, oral hygiene, and the vital role of saliva. Additionally, premature loss of primary teeth, crowding, orthodontic treatment, dental fillings, and prosthetic dental work can lead to iatrogenic issues affecting oral health. Recognizing the multifaceted nature of dental caries, susceptibility underscores the necessity for comprehensive strategies in oral health care. Therefore, this chapter underlines that proper oral care, preventive measures, and meticulous attention during dental procedures are paramount for maintaining optimal oral health.

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Section: Hormones and Vitaminsmentioning

confidence: 99%

Etiopathogenesis of Dental Caries

Barani-Sveçla,

Buleshkaj

2024

Dentistry

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“…Lipocalin-2, mainly released from granules of activated neutrophils, 21 can bind to iron, fatty acids, prostaglandins, steroids, and matrix metalloproteinases. 22 It plays a vital role in mediating innate immune responses to bacterial infections and chemoattraction of neutrophils, promoting their maturation, adhesion, extravasation, and phagocyte capacity.…”

Section: Introductionmentioning

confidence: 99%

Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study

Alkayali

Badria

ElBaiomy

et al. 2022

J Adv Periodontol Implant Dent

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Background. The aim of this study was the clinical and laboratory evaluation of using polycaprolactone (PCL) nanofibers loaded with oxytetracycline hydrochloride (OTC) and zinc oxide (ZnO) as an adjunct to mechanical therapy in managing stage II grade A periodontitis patients concerning GCF lipocalin2- levels. Methods. Fifty stage II grade A periodontitis patients (27 women and 23 men, with an age range of 30‒60) were enrolled in the study. The patients were randomly assigned to five equal groups and treated with scaling and root planing (SRP), followed by local application of PCL nanofibers: group I: SRP + PCL loaded with OTC and ZnO, group II: SRP + PCL loaded with OTC, group III: SRP + PCL loaded with ZnO, group IV: SRP + unloaded PCL, and group V: SRP alone. Additionally, 10 healthy subjects with healthy periodontium (group VI) (age- and gender-matched) served as the negative control. Nanofibers were applied in the selected pockets of periodontitis patients in groups I to IV once weekly for two months. All the participants were examined clinically by assessing periodontal indices (gingival index, plaque index, pocket depth, and clinical attachment level), and biochemically by assessing GCF lipocalin-2 levels. Results. Compared to controls, periodontitis groups (I, II, III, IV, and V) showed significant elevation of both clinical parameters and GCF lipocalin2- levels at baseline. In addition, these parameters improved significantly after treatment, which was more pronounced in groups I, II-, and III) compared to groups IV and V. However, it did not reach normal values. Conclusion. In association with SRP, PCL nanofibers loaded with OTC and ZnO had beneficial therapeutic effects at both clinical and laboratory levels.

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Periodontitis is associated with the increased levels of visfatin: a meta-analysis

Zhu,

Zhang,

Shi

et al. 2023

BMC Oral Health

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Objective Periodontitis is a common inflammatory disease associated with systemic factors. Visfatin is a pleiotropic adipokine that exerts metabolic and immune functions. Studies have shown visfatin played roles in the development of periodontitis. The present study aims to compare the levels of visfatin in body fluids including serum, saliva, and gingival crevicular fluid (GCF) between periodontitis patients and healthy individuals, and to elucidate the alteration of visfatin levels after periodontal treatments. Materials and methods The database searched included Pubmed, Embase, Web of Science, and Cochrane Library. According to the Eligibility criteria, the records were screened and the eligible studies were included. The methodological qualities of the included case-controlled studies were assessed according to the Newcastle–Ottawa scale (NOS). The Methodological Index for Nonrandomized Studies (MINORS) was applied for assessing the qualities of the included clinical trials. The statistical analyses were processed using STATA 15.0. Results Twenty-three studies were included in the statistical analyses. The meta-analysis showed significantly elevated visfatin levels of GCF, serum, and saliva in the periodontitis population compared with the controls (GCF: SMD = 5.201, 95% CI: 3.886–6.516, Z = 7.75, P < 0.05; Serum: SMD = 7.417, 95% CI: 3.068–11.767, Z = 3.34, P = P < 0.05; Saliva: SMD = 2.683, 95% CI: 1.202–4.163, Z = 3.34, P < 0.05). Visfatin levels of saliva serum and GCF were significantly decreased after periodontal treatment. (Saliva: SMD = -1.338, 95% CI: -2.289—0.487, Z = 39.77, P < 0.05; Serum: SMD = -2.890, 95% CI: -5.300–0.480, Z = 2.35, P < 0.05; GCF: SMD = -6.075, 95% CI: -11.032—1.117, Z = 2.40, P = 0.016; I 2 = 95.9%, P < 0.05). Conclusions Periodontitis elevated the visfatin levels in GCF, serum, and saliva. Additionally, GCF, serum, and saliva visfatin levels could be reduced after periodontal treatment.

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Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Cited by 4 publications

References 16 publications

Etiopathogenesis of Dental Caries

Etiopathogenesis of Dental Caries

Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study

Periodontitis is associated with the increased levels of visfatin: a meta-analysis

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