Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types

Guedes, João Victor Marques; Nunes, Natália R.; Ferreira, Letícia Gonçalves Resende; Vilar, Thaís G.; Pinheiro, Melina de Barros; Domingueti, Caroline Pereira

doi:10.5935/1676-2444.20180002

Cited by 6 publications

(7 citation statements)

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“…Even though the combination of estrogen and progesterone would be considered as advance formal of the OCP, the use of it still strongly associated with vascular disease. 47 The results indicated a significant increase in CRP in the OCP users as compared to the control group; this finding is in agreement with Divani et al 48 , Ferreira et al, (2017), Guedes et al 49 , and Oliveira et al 50 It was indicating that OCP leads to an increased subclinical inflammatory process. Divani et al 51 established that progestin increases interleukin 6 (IL-6, an inflammatory-mediated stimulation) of CRP in combination with conjugated equine estrogen and showed that IL-6 change was negatively linked to CRP change when subjects were treated only with equine estrogen.…”

Section: Discussionsupporting

confidence: 78%

Effect of Oral Contraceptive Pills on Oxidative Stress in Saudi women

Osman

Al-Mutairi

2021

J. Contemp. Med. Sci.

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Objective: The aim of this study was to evaluate the effect of oral contraceptive pills on oxidative stress in Saudi women. Methods: A total of fifty-five Saudi women were divided into two groups: users of oral contraceptive pills (OCP, N=30) for at least one year and non-users (NOCP, N=25). The demographic data were obtained through face-to-face interviews performed by the researcher. Blood specimen from both groups were drawn after 8 hours of fasting to estimate serum Total antioxidant (TAOC), Nitric oxide (NO), C-reactive protein (CRP), vitamins (E, B6, B12) and some hematological parameters: hemoglobin (Hb), Red blood cell (RBC), White blood cell (WBC). Results: The results showed a significant decreased in serum TAOC, NO, vitamins E and B6 accompanied with high significant increase in CRP level while no significant changes B12, HB, RBC and WBC were observed in the OCP users as compared to the control group. Conclusion: The results of this study indicated that the use of OCP resulted in low levels of the total antioxidant, nitric oxide, vitamin E, and B6 with a significant increase in CRP. Women who used OCP may be more susceptible to oxidative stress by enhanced depletion of antioxidants.

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Section: Discussionsupporting

confidence: 78%

Effect of Oral Contraceptive Pills on Oxidative Stress in Saudi women

Osman

Al-Mutairi

2021

J. Contemp. Med. Sci.

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“…The more significant levels of VLDL-C present in the prophylactic gatherings could likewise be ascribed to the estrogen chemical, which could build the liver's discharge of this lipoprotein, to raise fatty oil levels higher in ladies who use contraceptives when contrasted with the benchmark group, since VLDL-C is a lipoprotein wealthy in fatty substances [16]. The result showed that the degree of VLDL-C in the blood was essentially higher in women taking contraceptive pill contrasted with healthy group, the degree of VLDL-C expanded with age and term contraceptive pill use [13,23]. Changes with age and span of utilization can be clarified by the impact of estrogen on these lipoproteins.…”

Section: Resultsmentioning

confidence: 94%

“…The results showed a significant increase (P ≤0.05) in the concentration of TC, TG, LDL-C and VLDL-C in ladies who have the contraceptive pill compared with control group, while there was a significant decrease the lipase activity and HDL-C in ladies have the contraceptive pill, compared with the control group, as showed in table 1. The preventative pill (containing estrogen and progesterone) influences the cardiovascular framework all the more habitually through its blackout on cardiovascular danger elements and lipids, oral contraceptives change lipid levels through the genomic pathway, and progestogens have a more prominent capacity to adjust the advantageous impacts of estrogen on lipids [13].…”

Section: Resultsmentioning

confidence: 99%

Measurement of lipids levels and lipase enzyme in women who take birth control pills in Samarra

et al. 2021

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The current study aimed to explicate the effect of preventative pill effect on the lipids levels and lipase activity. The study design included two groups each consists of thirty women; preventative pill group (women who were taking contraceptive pills) and control group (women who were not taking contraceptive pills), their ages ran between (20-40) year. Blood samples were collected for the period from 1/11/2019 to 3/1/2020. Results of this study showed that there was a significant increase in the levels of total cholesterol (TC), Triglycerides (TG), low-density lipoproteins-cholesterol (LDL-C) and very low-density lipoproteins-cholesterol (VLDL-C) in contraceptive pills group compared to control group, while there was a significant decrease in Lipase activity and high-density lipoprotein-cholesterol (HDL-C) level in contraceptive pills group compared with control group.

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“…OCs are reported that may be related to hypertension, [ 32 ] diabetes, [ 33 ] and hyperlipidemia. [ 34 ] A larger portion of PCOS was also noted in the Diane-35 cohort, which may be associated with hyperlipidemia. [ 35 ] Nevertheless, in our analysis, these comorbidities were adjusted, and found the association between Diane-35 use and thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Women consuming oral contraceptives containing cyproterone acetate and ethinylestradiol show a higher risk of thyroid cancer than nonusers

et al. 2023

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This study explored whether the risk of thyroid cancer in Asian women is associated with consumption of oral contraceptives (Diane-35). We conducted a population-based, retrospective cohort study using the Taiwan National Health Insurance Research Database. From the database, 9865 women aged 18 to 65 years who were prescribed Diane-35 between 2000 and 2012 were included in the Diane-35 group, and 39,460 women who were not prescribed Diane-35 were included in the comparison group and were frequency-matched by age and index year. Both groups were followed until 2013 to calculate the incidence of thyroid cancer. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard model. The median (standard deviation) follow-up duration was 7.08 (3.63) and 7.04 (3.64) years in the Diane-35 and the comparison group, respectively. The incidence of thyroid cancer was 1.80-fold higher in the Diane-35 group than in the comparison group (2.72 vs 1.51 per 10,000 person-years). The cumulative incidence of thyroid cancer was significantly higher in the Diane-35 group than in the comparison group (log-rank test, P = .03). An elevated hazard ratio of thyroid cancer was observed in the Diane-35 group than in the comparison group (HR: 1.91, 95% CI: 1.10–3.30). In subgroup analysis, patients aged 30 to 39 years showed a higher hazard ratio of developing thyroid cancer after consuming Diane-35 than those in the comparison group (HR: 5.58, 95% CI: 1.84–16.91). The study provides evidence that women aged 30 to 39 years consuming Diane-35 are at increased risk of thyroid cancer. Nevertheless, a larger population with a longer follow-up may be necessary to confirm causality.

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Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types

Cited by 6 publications

References 0 publications

Effect of Oral Contraceptive Pills on Oxidative Stress in Saudi women

Effect of Oral Contraceptive Pills on Oxidative Stress in Saudi women

Measurement of lipids levels and lipase enzyme in women who take birth control pills in Samarra

Women consuming oral contraceptives containing cyproterone acetate and ethinylestradiol show a higher risk of thyroid cancer than nonusers

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