Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors

Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch)

“…Li, Li, Wang, Asada, and Koike (2010) evaluated PTP1B inhibitory activities of prenylflavonoids from G. uralensis and revealed that glycybenzofuran and glisoflavone with IC50 of 25.5 and 27.9 µM, respectively, significantly inhibit PTP1B. Likewise, Li et al (2013) found that glycybenzofuran, a licorice flavonoid, exhibits efficient inhibitory selectivity and cellular activity on insulinstimulated Akt phosphorylation levels.…”

Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice

“…Although some of flavonoids and anthocyanins could be suppressed the Akt phosphorylation [40], this will be further studied in the near future.…”

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

“…Glycybenzofuran and glisoflavone, two flavonoids of G. uralensis, significantly inhibit PTP1B activity; hence, they could be targets for treatment of type 2 diabetes mellitus and obesity (Li et al, 2010b). Similarly, glycybenzofuran was recently reported as a potent competitive inhibitor of PTP1B (Li et al, 2013a). In one study, glabrol noncompetitively inhibited rat liver microsomal acyl-coenzyme A : diacylglycerol acyltransferase activity with an IC 50 of 8 μM .…”