Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice

Kim, Jong Min; Park, Seon Kyeong; Guo, Tian; Kang, Jin Yong; Ha, Jeong Su; Lee, Du Sang; Lee, Uk; Heo, Ho Jin

doi:10.1016/j.bbr.2016.06.013

Cited by 35 publications

(56 citation statements)

References 49 publications

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“…Bone strength also markedly decreased in osteoporosis, regardless of the cause (Diez, 2002;Joo et al, 2016;Jung et al, 2016;Kang et al, 2016;Syed & Khan, 2002 (Table 4). These findings can be regarded as direct evidence that EAP : DM 3:1 (g/g) synergistically increased the bone strength-preserving effects of separate formulations of EAP and DM.…”

Section: Effects On Bone Strengthmentioning

confidence: 91%

“…With the exception of ash bone weight, it is generally accepted that changes in bone weight is not a critical index for the detection of the efficacy of antiosteoporotic agents (Xie et al, 2005;Yamamoto et al, 1998), although, trends of increasing relative bone weights have been considered a valuable marker of antiosteoporotic activity (Joo et al, 2016;Kang et al, 2016…”

Section: Effects On Bone Weightmentioning

confidence: 99%

“…BMD, regarded as a valuable index of bone quality changes in clinical settings, is significantly decreased in osteoporotic animals, regardless of the cause (Diez, 2002;Joo et al, 2016;Jung et al, 2016;Kang et al, 2016;Syed & Khan, 2002). BMD has provided good predictive information about the efficacy of antiosteoporotic agents (Syed & Khan, 2002 Figure 2).…”

Section: Effects On Bmdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Dendropanax morbifera Léveille (Araliaceae) is a tree that grows mainly on Jeju Island and some portions of the Korean coastline along the southwestern sea (Kim, Lee, Kim, Heo, & Son, ; Kim, Park, et al, ). Traditionally, it has been used to prepare tea and medicine for liver disease and immunological enhancement (Kim, Lee, et al, ; Kim, Park, et al, ; Kim, Yim, et al, ). Dendropanax morbifera (DM) extracts have been reported to exert various effects, including immune activation against cancer cells, antioxidant effects (Hyun et al, ; Lee, Park, Hwang, Kim, & Lee, ), diabetes treatment and prevention (Moon, ), and insecticidal effects (Chung, Kim, Park, & Moon, ).…”

Section: Introductionmentioning

confidence: 99%

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Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified fromAureobasidium pullulansSM-2001 andDendropanax morbiferaleaf extracts in ovariectomized rats

Cho¹,

Jeong²,

Kim³

et al. 2018

J Food Biochem

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The dose‐dependent antiosteoporotic potentials of the exopolymers from Aureobasidium pullulans (EAP): Dendropanax morbifera (DM) 3:1 (g/g) were observed in bilateral ovariectomized (OVX) rats. Twenty‐eight days after bilateral OVX surgery, 200 mg/kg EAP or DM, and 400, 200, and 100 mg/kg EAP : DM (3:1) were orally administered, once a day for 56 days. We measured changes in body weight and weight gain, bone weight, length, thickness, strength, and bone mineral density and contents. Additionally, histological profiles and histomorphometric analyses of serum biochemistry and urine biochemistry were conducted at sacrifice. Femur, tibia, and the 4th or 5th lumbar vertebrae were sampled, and histomorphometry of bone mass, structure, and resorption were also performed. In this study, the findings suggest that EAP : DM (3:1) synergistically increased the distinct antiosteoporotic potentials of the single formulations of EAP and DM in OVX rats, suggesting a promising new potent protective agent for relieving osteoporosis in menopausal women. Practical applications Osteoporosis is a metabolic bone disease characterized by decreased bone strength, leading to increased risk of fractures. EAP have antiosteoporotic activity and DM has various health beneficial effects including immunological enhancement. We hypothesized that appropriated mixtures consisting of EAP and DM leaf extracts (EAP : DM) will show more favorable synergistic antiosteoporotic effects due to increases in the diversity of bioactive ingredients. In the present study, rats treated with 200 mg/kg of EAP : DM 3:1 (g/g) showed significantly more favorable inhibitory activity against estrogen‐deficient osteoporosis symptoms induced by OVX compared with those treated with 200 mg/kg of EAP or DM. Therefore, EAP : DM 3:1 (g/g) may be a promising new potent protective agent for relieving osteoporosis in menopausal women.

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Section: Effects On Bone Strengthmentioning

confidence: 91%

Section: Effects On Bone Weightmentioning

confidence: 99%

Section: Effects On Bmdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified fromAureobasidium pullulansSM-2001 andDendropanax morbiferaleaf extracts in ovariectomized rats

Cho¹,

Jeong²,

Kim³

et al. 2018

J Food Biochem

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Effects of Dendropanax morbifera Léveille extract on hypothyroidism-induced oxidative stress in the rat hippocampus

Yoo

Jung

Kwon

et al. 2016

Food Sci Biotechnol

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In this experiment, we verified the effects of Léveille stem extract (DMS) on hypothyroidism-induced oxidative stress in the hippocampus of rats. Hypothyroidism was induced in rats by treating them with 0.03% 2-mercapto-1-methyl-imidazole dissolved in drinking water for 5 weeks. DMS (100 mg/kg) was also orally administered to the rats during the same period and the animals were sacrificed at 12 weeks of age. DMS administration tended to ameliorate these hypothyroidism-induced changes in serum triiodothyronine (T), thyroxine (T), and thyroid-stimulating hormone levels. DMS administration significantly reduced the hypothyroidism-induced increases in reactive oxygen species production as well as in lipid peroxidation in the hippocampus. In addition, DMS administration increased hippocampal Cu, Zn-superoxide dismutase (SOD1), catalase (CAT), and glutathione peroxidase (GPx) levels. These results suggest that DMS potentially ameliorates hypothyroidism-induced neuroendocrine phenotypes and oxidative stress in the hippocampus via the induction of antioxidant enzymes.

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The role of microRNAs in diseases and related signaling pathways

et al. 2021

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Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice

Cited by 35 publications

References 49 publications

Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified fromAureobasidium pullulansSM-2001 andDendropanax morbiferaleaf extracts in ovariectomized rats

Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified fromAureobasidium pullulansSM-2001 andDendropanax morbiferaleaf extracts in ovariectomized rats

Effects of Dendropanax morbifera Léveille extract on hypothyroidism-induced oxidative stress in the rat hippocampus

The role of microRNAs in diseases and related signaling pathways

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