Evaluation of laser direct infrared imaging for rapid analysis of pharmaceutical tablets

Abstract

Vibrational spectroscopic chemical imaging is an important tool in the pharmaceutical industry for characterising the spatial distribution of components within final drug products. The applicability of these techniques are currently...

Quantitative analysis of drug tablet aging by fast hyper-spectral stimulated Raman scattering microscopy

“…26 Recently, laser direct infrared imaging (LDIR) has gained traction for chemical imaging of tablets within seconds at high spectral resolution and spatial resolution up to 10 μm. 27,28 This method couples a quantum cascade laser (QCL) with an infrared microscope to obtain signal at specific spectral bands, greatly reducing imaging time compared to NIR. However, it still fails to identify small API domains particularly at low concentrations when compared to confocal Raman imaging.…”

“…However, it still fails to identify small API domains particularly at low concentrations when compared to confocal Raman imaging. 27 Given the current methods of CI and their drawbacks, there is a clear need for a new CI tool with fast acquisition time, low background, high resolution, and high chemical sensitivity, particularly for low concentration APIs. We propose sparse spectral sampling stimulated Raman scattering (S 4 RS), an extension of stimulated Raman scattering (SRS) microscopy, for this purpose.…”

“…However, it still fails to identify small API domains particularly at low concentrations when compared to confocal Raman imaging. 27…”

Raman spectroscopy for the quantitative analysis of Lornoxicam in solid dosage forms

“…The LDIR chemical imaging approach gives researchers the opportunity to get detailed domain morphology information in a fraction of the time. [ 15 ]…”

“…The LDIR chemical imaging approach gives researchers the opportunity to get detailed domain morphology information in a fraction of the time. [15] Raman spectroscopy was employed for a variety of analytical applications including disease diagnosis [16] in the fields of food and agricultural products, [17] such as fruits and vegetables, crops, beef, and dairy items, analysis of chemical and biological products, [18] and identification and differentiation of different bacteria. [19,20] By using Raman spectroscopy, different pharmaceuticals have been analyzed such as sitagliptin, [18] cefixime, [21] amoxicillin, and losartan potassium.…”