Raman imaging studies on the stability of Paracetamol tablets under different storage conditions

Fateixa, Sara; Mulandeza, Otílio; Nogueira, Helena I. S.; Trindade, Tito

doi:10.1016/j.vibspec.2022.103488

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…Besides visualizing drug component distribution in formulations, another important application of Raman is imaging and tracking the dynamic processes of formulation stability and dissolution/solubilization over time. For example, Fateixa et al used confocal RS imaging to investigate degradation mechanisms and tablet compositional changes under various storage conditions . Abouselo et al revealed a reliance on salt disproportionation reactions for excipient-influenced microenvironmental pH in situ .…”

Section: Imaging Dynamic Changes In Drug Formulationsmentioning

confidence: 99%

“…For example, Fateixa et al used confocal RS imaging to investigate degradation mechanisms and tablet compositional changes under various storage conditions. 202 Abouselo et al revealed a reliance on salt disproportionation reactions for excipient-influenced microenvironmental pH in situ. 203 Excipients also influence API release, which can be determined by in vitro dissolution profiles.…”

Section: Formulationsmentioning

confidence: 99%

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Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging

Dunnington,

Wong,

2024

Anal. Chem.

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Section: Imaging Dynamic Changes In Drug Formulationsmentioning

confidence: 99%

Section: Formulationsmentioning

confidence: 99%

Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging

Dunnington,

Wong,

2024

Anal. Chem.

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“…In the past 15 years, both NIR and Raman imaging have been used in the analysis of pharmaceutical tablets to measure their active ingredient content [ 12 , 13 ], to characterize the size of components [ 14 , 15 ], to measure the coating thickness of film-coated tablets [ 16 , 17 ], to characterize the distribution of polymorphic forms of a drug [ 18 , 19 ], to detect changes after storage under stress [ 20 , 21 ], to recognize counterfeit products [ 22 , 23 ], to identify the components of a formulation [ 24 ] and to predict the dissolution profile of tablets [ 6 , 25 , 26 ]. It is evident that both techniques are capable of great things; however, the aforementioned works provide little help in deciding which imaging method is worth using to achieve a specific goal.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Performance of Raman and Near-Infrared Imaging in the Prediction of the In Vitro Dissolution Profile of Extended-Release Tablets Based on Artificial Neural Networks

Galata,

Gergely,

Nagy

et al. 2023

Pharmaceuticals

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In this work, the performance of two fast chemical imaging techniques, Raman and near-infrared (NIR) imaging is compared by utilizing these methods to predict the rate of drug release from sustained-release tablets. Sustained release is provided by adding hydroxypropyl methylcellulose (HPMC), as its concentration and particle size determine the dissolution rate of the drug. The chemical images were processed using classical least squares; afterwards, a convolutional neural network was applied to extract information regarding the particle size of HPMC. The chemical images were reduced to an average HPMC concentration and a predicted particle size value; these were used as inputs in an artificial neural network with a single hidden layer to predict the dissolution profile of the tablets. Both NIR and Raman imaging yielded accurate predictions. As the instrumentation of NIR imaging allows faster measurements than Raman imaging, this technique is a better candidate for implementing a real-time technique. The introduction of chemical imaging in the routine quality control of pharmaceutical products would profoundly change quality assurance in the pharmaceutical industry.

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“…In recent years, different methods have been identified for the detection or quantification of AC: highly sophisticated chromatographic used for the simultaneous detection and quantification of AC with other substances [3,4], capillary electrophoresis-mass spectrometry [5], and vibrational methods in commercial AC tablets, where the unknown nature of the excipients used negatively influenced the accuracy of the method [6][7][8]. Also, the spectrofluorimetric method at ultra-trace levels where an aqueous mixture of sulfuric acid was used.…”

Section: Introductionmentioning

confidence: 99%

A Facile Glycerol-Assisted Synthesis of Low-Cu2+-Doped CoFe2O4 for Electrochemical Sensing of Acetaminophen

Alfonso-González,

Granja-Banguera,

Morales-Morales

et al. 2023

Biosensors

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This work devised a simple glycerol-assisted synthesis of a low-Cu2+-doped CoFe2O4 and the electrochemical detection of acetaminophen (AC). During the synthesis, several polyalcohols were tested, indicating the efficiency of glycerin as a cosolvent, aiding in the creation of electrode-modifier nanomaterials. A duration of standing time (eight hours) before calcination produces a decrease in the secondary phase of hematite. The synthesized material was used as an electrode material in the detection of AC. In acidic conditions (pH 2.5), the limit of detection (LOD) was 99.4 nM, while the limit of quantification (LOQ) was found to be (331 nM). The relative standard deviation (RSD), 3.31%, was computed. The enhanced electrocatalytic activity of a low-Cu2+-doped CoFe2O4-modified electrode Cu0.13Co0.87Fe2O4/GCE corresponds extremely well with its resistance Rct, which was determined using the electrochemical impedance spectroscopy (EIS) technique and defined its electron transfer capacity. The possibility of a low-Cu2+-doped CoFe2O4 for the electrochemical sensing of AC in human urine samples was studied. The recovery rates ranging from 96.5 to 101.0% were obtained. These findings suggested that the Cu0.13Co0.87Fe2O4/GCE sensor has outstanding practicability and could be utilized to detect AC content in real complex biological samples.

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Raman imaging studies on the stability of Paracetamol tablets under different storage conditions

Cited by 4 publications

References 62 publications

Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging

Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging

Comparing the Performance of Raman and Near-Infrared Imaging in the Prediction of the In Vitro Dissolution Profile of Extended-Release Tablets Based on Artificial Neural Networks

A Facile Glycerol-Assisted Synthesis of Low-Cu2+-Doped CoFe2O4 for Electrochemical Sensing of Acetaminophen

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