Evaluation of l -dopa, proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans: A future drug for Parkinson treatment

Comparative evaluation of Nardostachys jatamansi and Mucuna pruriens as neuroprotective in Parkinson's disease

“…Hedgecock et al (2019) have reported that reserpine significantly reduces levels of dopamine, norepinephrine and 5-hydroxy tryptamine due to catabolism by monoamine oxidase enzymes, resulted in akinesia. As per study of Lieu et al (2012); Aware et al (2017), L-dopa (dopamine precursor) is an active chemical constituent and supportive constituents present in mucuna prurins fulfills the requirement of dopamine, resulted in improved motor action induced by reserpine significantly. Sahu et al (2016) was reported that Sesquiterpenes, jatamansone, nardostachone are major constituents in Nardostachys jatamansi and drug induced decreased locomotor activity was significantly restored.…”

“…In parkinsons disease bradykinesia, tremors, stiffness of limbs and torso, and postural instability are the four main symptoms from which at least two need to present for epidemiological study of parkinsons disease. Due to dopaminergic cell degeneration excessive activation of ionotropic Glu receptors causes overexcitement of high concentration of Glu and damage neurons called as excitotoxicity, microglial activation, oxidative stress, neuroinflammation and mitochondrial dysfunction leads to apoptosis (Ray et al, 2018;Aware et al, 2017).…”

Bioactive Components of Magical Velvet Beans

“…Seeds of Mucuna are commonly used part of the plant, which are a rich source of nutritional and anti-nutritional compounds like l-dopa (anti-Parkinson's activity), antioxidants, phenolic, flavonoids, tannin, carbohydrates, starch, protein, micronutrients Sopanines and many more [9,12,26]. Antioxidant activities in this plant are mainly due to phenolic and various bioactive compounds present in the seed material [36,37].…”

“…Antioxidant activities in this plant are mainly due to phenolic and various bioactive compounds present in the seed material [36,37]. There are various extraction techniques, different solvents and processing methods that were used to extract the biologically active compounds from the seed of Mucuna [26,31]. The prior study reports that M. macrocarpa, M. sanjappae and M. atropurpurea disclosed a higher level of l-dopa content, which also concludes that l-dopa content has a positive correlation to the protein content of seeds [12].…”

“…Numerous studies on antioxidant activity and phytoconstituents content of Mucuna seeds, leaves and roots were performed previously [4,7,19,30,31,[59][60][61][62]. Optimization of different solvents for the extraction of antioxidants was done by Aware and Patil et al [9,10,26]. They concluded that depending on solubility of antioxidant compounds present in different species of Mucuna, concentration of antioxidants differs.…”