Evaluation of Iron Status in Anemia of Chronic Disease Among Patients With HIV Infection

Ogbe, P. J.; Idoko, O. A.; Ezimah, A. C. U.; Digban, Kester Awharentomah; Oguntayo, Beatris Olatundun

doi:10.29074/ascls.25.1.7

Cited by 8 publications

(4 citation statements)

References 9 publications

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“… 17 In some cases, iron deficiency anemia secondary to HIV, related to gastrointestinal blood loss has been reported. 15 – 17 This is the probable explanation for the occurrence of microcytosis in our study. The etiology of vitamin B12 deficiency in these patients has been linked to malabsorption in the distal ileum and an alteration in cobalamin transport proteins.…”

Section: Discussionsupporting

confidence: 58%

Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

Katemba

Muzoora

Muwanguzi

et al. 2018

JBM

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Aim/objectiveTo assess the common hematological abnormalities among HIV-antiretroviral therapy (ART) naïve clients attending an immune suppression syndrome (ISS) clinic at Mbarara Regional Referral Hospital (MRRH), southwestern Uganda.Patients and methodsThis was a cross-sectional study carried out during the months of March to August 2016 at the ISS clinic of MRRH. We collected approximately 4.0 mL of EDTA anticoagulated blood samples, which were assayed for complete blood count, CD4+ cell count and thin film examination. Correlation of the hematological abnormalities with CD4+ cell counts was done using correlation coefficient (r) and analysis of variance (F), and the p-value was set at ≤0.05.ResultsA total of 141 clients were enrolled. Of these, 67.38% (95/141) were anemic, 26.24% (40/141) had thrombocytopenia while 26.95% (38/141) had leucopenia. Of the 95 participants with anemia, 89.47% (85/95) presented with normocytic-normochromic anemia, 8.42% (8/95) with microcytic-hypochromic anemia and 2.11% (2/95) with macrocytic-hypochromic anemia. Anemia was not different across the several World Health Organization (WHO) stages of HIV infection disease progression (p>0.05). Statistically significant differences were present among participants with leucopenia (p<0.05). Also, leucopenia was more prevalent (11/38) among participants in WHO stage 4 of HIV infection. CD4+ cell counts correlated with thrombocytopenia (r=0.24, p<0.05) and leucopenia (r=0.15, p<0.05).ConclusionPeople living with HIV/AIDS (PLWHIV/AIDS) ought to be routinely monitored and treated for the occurrence of hematological abnormalities. Early initiation of ART can help to prevent some hematological abnormalities.

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Section: Discussionsupporting

confidence: 58%

Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

Katemba

Muzoora

Muwanguzi

et al. 2018

JBM

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“…11 This is due to decreased ability of the bone marrow to produce blood cells, resulting in deficiency nutrition, and disorders of the immune system of people with HIV. [12][13][14] In this study, it was known that most subjects had normal hematological parameters. The mean Hb, Ht, erythrocyte, leukocyte and platelet counts in this study were still within normal limits.…”

Section: Discussionmentioning

confidence: 84%

N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

Yuniza

Salim²,

Kurniati³

et al. 2020

J. Drug Delivery Ther.

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Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS patients who are undergoing ARV treatment. Method: This was a pilot study using a double blind randomized clinical trial. A total of 32 subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely placebo and NAC. Subjects in the NAC group were given NAC at a dose of 3x200 mg/day, while the placebo group was given lactose at a dose of 3x200 mg/day. Each group was given treatment for 12 weeks. Before and after treatment, subjects were examined for hematologic parameters. Results: Most of subjects had normal hematological features. NAC administration did not have a significant effect on the mean levels of Hb, Ht, number of erythrocytes, leukocytes and platelets (p> 0.05). However, NAC administration can reduce the degree of anemia and improve the condition of thrombocytopenia, leukopenia and lymphopenia. Conclusion: NAC administration can reduce hematological abnormalities HIV/AIDS patients undergoing ARV treatment. Keywords: ARV, Hematological abnormalities, HIV/AIDS, NAC.

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“…Aproximadamente en un 15 a 30% de los pacientes presentan macrocitosis con una dosificación de vitamina B12 y ácido fólico por debajo de valores normales, esta condición probablemente esté relacionada al uso de antirretrovirales y antibióticos, además el transporte de vitaminas y/o una pobre absorción de éstas causadas por una enteropatía de causa infecciosa, pese a que los pacientes consumen altas dosis de ácido fólico. (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) La leucopenia (leucocitos < 4000/mm3), se presenta la mayoría de las veces en forma concomitante con la anemia. La infección por VIH afecta a todas las células de la serie blanca: neutrófilos, linfocitos y monocitos.…”

Section: Introductionunclassified

Alteraciones hematológicas en pacientes portadores del virus de lnmunodeficiencia Humana

Toro

Vasco

Vasco³

et al. 2020

CCD

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La infección por el Virus de la Inmunodeficiencia Humana, VIH se presenta con una variedad de alteraciones hematológicas y pueden verse como complicación de la propia enfermedad o vinculadas al tratamiento. Se caracteriza por una eritropoyesis ineficaz causada por infecciones oportunistas, neoplasias y fármacos. En este artículo se quiere determinar las alteraciones hematológicas más frecuentes que se producen en pacientes portadores del virus de la inmunodeficiencia humana atendidos en el Hospital Enrique Garcés, localizado en Quito, Ecuador. Se realizó un muestreo aleatorio simple para universo finito. El estudio es de tipo descriptivo retrospectivo de una serie de casos en la Unidad de atención integral a pacientes con VIH-SIDA del Hospital Enrique Garcés. Se revisaron las historias clínicas de los pacientes atendidos en el año 2017. Se obtuvo una muestra de 105 pacientes. Se evidenció que la mayoría (86,7%) de los casos corresponde al sexo masculino con una edad promedio de 33 años. La prevalencia de anemia fue del 13.3 %. Las mujeres presentaron más alta prevalencia de anemia. La leucopenia fue más frecuente en el grupo de pacientes con valores de CD4 inferiores 200 cells/μ. Se concluye que la prevalencia de anemia no fue muy elevada, predominó en el sexo femenino con un patrón normocítico hipocrómico. La leucopenia fue más frecuente en el grupo de pacientes con valores de CD4 inferiores 200 cells/μ. Las plaquetas en la mayoría de pacientes estuvieron en rango normal.

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Evaluation of Iron Status in Anemia of Chronic Disease Among Patients With HIV Infection

Cited by 8 publications

References 9 publications

Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

Alteraciones hematológicas en pacientes portadores del virus de lnmunodeficiencia Humana

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Evaluation of Iron Status in Anemia of Chronic Disease Among Patients With HIV Infection

Cited by 8 publications

References 9 publications

Hematological abnormalities in HIV-antiretroviral therapy na&iuml;ve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

Hematological abnormalities in HIV-antiretroviral therapy na&iuml;ve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

Alteraciones hematológicas en pacientes portadores del virus de lnmunodeficiencia Humana

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Product

Resources

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Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda

Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda