Evaluation of ionic liquids-coated carbon nanotubes modified chiral separation system with chondroitin sulfate E as chiral selector in capillary electrophoresis

Zhang, Qi; Du, Yingxiang; Du, Shuaijing

doi:10.1016/j.chroma.2014.02.003

Cited by 47 publications

(29 citation statements)

References 48 publications

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“…In this regard, IL‐coated MWNTs modified chiral separation systems for CE enantioseparation with chondroitin sulfate E as the chiral selector has been demonstrated. The authors reported significantly improved separations, including better enantioselectivity and improved peak shapes, were obtained in the ILs‐MWNTs modified separation system for the drug enantiomers tested .…”

Section: Carbon‐based Npsmentioning

confidence: 99%

Recent advances in nanomaterial‐based capillary electrophoresis

et al. 2019

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This review gives a summary of applications of different nanomateials, such as gold nanoparticles (AuNPs), carbon‐based nanoparticles, magnetic nanoparticles (MNPs), and nano‐sized metal organic frameworks (MOFs), in electrophoretic separations. This review also emphasizes the recent works in which nanoparticles (NPs) are used as pseudostationary phase (PSP) or immobilized on the capillary surface for enhancement of separation in CE, CEC, and microchips electrophoresis.

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Section: Carbon‐based Npsmentioning

confidence: 99%

Recent advances in nanomaterial‐based capillary electrophoresis

et al. 2019

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“…By employing different chiral selectors , the interactions between chiral analytes and chiral selectors can be adjusted, resulting in the effective separation of chiral compounds. These chiral selectors, which are usually utilized as additives in the buffer or stationary phase in the capillary to form CEC systems, include cyclodextrins , cyclofructans , polysaccharides , celluloses , polymeric surfactants , antibiotics and many other molecules.…”

Section: Introductionmentioning

confidence: 99%

Covalent bonding of homochiral metal‐organic framework in capillaries for stereoisomer separation by capillary electrochromatography

2015

Electrophoresis

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In this work, a [Cu(mal)(bpy)]⋅H2O (mal, L-(-)-malic acid; bpy, 4,4'-bipyridyl) homochiral metal-organic frameworks (MOFs) was synthesized and used for modifying the inner walls of capillary columns by utilizing amido bonds to form covalent links between the MOFs particles and capillary inner wall. The synthesized [Cu(mal)(bpy)]⋅H2 O and MOFs-modified capillary column were characterized by X-ray diffraction, thermogravimetric analysis, particle size distribution analysis, nitrogen absorption characterization, FTIR spectroscopy, SEM, and energy-dispersive X-ray spectroscopy (EDX). The MOFs-modified capillary column was used for the stereoisomer separation of some drugs. The LODs and LOQs of six analytes were 0.1 and 0.25 μg/mL, respectively. The linear range was 0.25-250 μg/mL for ephedrine, 0.25-250 μg/mL for pseudoephedrine, 0.25-180 μg/mL for D-penicillamine, 0.25-120 μg/mL for L-penicillamine, 0.25-180 μg/mL for D-phenylalanine, and 0.25-160 μg/mL for L-phenylalanine, all with R(2) > 0.999. Finally, the MOFs-modified capillary column was applied for the analysis of active ingredients in a real sample of the traditional Chinese medicine ephedra.

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“…Various analytical techniques have been developed for chiral separation. Among them, CE has been regarded as an attractive technique over the last few decades due to its several advantages such as high separation efficiency, short analysis time, convenient change in separation condition, and extremely small volume requirements for sample and separation media .…”

Section: Introductionmentioning

confidence: 99%

Tetramethylammonium‐lactobionate: A novel ionic liquid chiral selector based on saccharides in capillary electrophoresis

Zhang

et al. 2015

Electrophoresis

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Chiral ionic liquids (ILs) have aroused widespread interest in separation science; however, only a few papers have reported the application of chiral ILs in CE for enantioseparation, and the use of chiral ILs as the sole chiral selector in an electrophoretic or a chromatographic system was reported in only three papers. In this study, we designed a lactobionic acid LA-based IL, tetramethylammonium-lactobionate (TMA-LA), and it is very interesting to find that the chiral separation capability can be remarkably improved when a conventional saccharide chiral selector evolved into an IL chiral selector. A comparative study of the enantiorecognition capability of three separation systems (single LA system, LA + TMA-chloride (TMA-Cl) system, and TMA-LA IL system) was also conducted, and the results showed that the use of TMA-LA IL as the sole chiral selector exhibited a remarkable superiority. A series of parameters affecting the enantioseparation, such as the type and proportion of organic modifier, buffer composition and pH, chiral selector concentration, as well as applied voltage were systematically investigated. The best enantioseparation was obtained at pH 7.6 using a 40 mM borax buffer with 40% v/v methanol, 200 mM TMA-LA, and 20 kV applied voltage. It is the first time that a saccharide-based IL is evaluated as a sole chiral selector in CE, and we hope this study would provide a new direction for the development of novel ILs chiral selectors based on conventional chiral selectors.

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Evaluation of ionic liquids-coated carbon nanotubes modified chiral separation system with chondroitin sulfate E as chiral selector in capillary electrophoresis

Cited by 47 publications

References 48 publications

Recent advances in nanomaterial‐based capillary electrophoresis

Recent advances in nanomaterial‐based capillary electrophoresis

Covalent bonding of homochiral metal‐organic framework in capillaries for stereoisomer separation by capillary electrochromatography

Tetramethylammonium‐lactobionate: A novel ionic liquid chiral selector based on saccharides in capillary electrophoresis

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