Evaluation of Intestinal Absorption of Ginsenoside Rg1 Incorporated in Microemulison Using Parallel Artificial Membrane Permeability Assay

Han, Min; Fu, Shao; Gao, Jian; Fang, Xiao

doi:10.1248/bpb.32.1069

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…Experiments to increase the bioavailability of ginsenosides include co-administration of ginsenosides with adrenaline [86], emulsification of ginsenosides into lipid-based formulation [87,88] and suppression of p-glycoprotein efflux system [77]. P-glycoprotein-mediated multidrug resistance is a major obstacle to effective cancer treatments.…”

Section: Reviewmentioning

confidence: 99%

Pharmacology of ginsenosides: a literature review

2010

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The therapeutic potential of ginseng has been studied extensively, and ginsenosides, the active components of ginseng, are shown to be involved in modulating multiple physiological activities. This article will review the structure, systemic transformation and bioavailability of ginsenosides before illustration on how these molecules exert their functions via interactions with steroidal receptors. The multiple biological actions make ginsenosides as important resources for developing new modalities. Yet, low bioavailability of ginsenoside is one of the major hurdles needs to be overcome to advance its use in clinical settings.

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Section: Reviewmentioning

confidence: 99%

Pharmacology of ginsenosides: a literature review

2010

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“…Some studies has been developed to overcome this problem, such as coadministration with adrenalin [38] or using lipid-based formulations [39, 40] and the suppression of p-glycoprotein efflux system [30] that are proven to increase the oral bioavailability of ginsenosides.…”

Section: Bioavailabilitymentioning

confidence: 99%

A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders

Rokot

Kairupan

Cheng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years. Ginseng is recorded to have exhibited a wide variety of beneficial pharmacological effects and has become a popular and worldwide known health supplement and drug. The protective effects of ginseng on central nervous system are discussed in this review. Ginseng species and ginsenosides and their intestinal metabolism and bioavailability are concisely introduced. The molecular mechanisms of the effects of ginseng on central nervous system, mainly focused on the neuroprotection properties of ginseng, memory, and learning enhanced properties, and the effects on neurodegenerative disorders are presented. Thus, ginseng and its constituents are of potential merits in the treatment of cerebral disorders.

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“…straightforward manner with the permeability equation described by Avdeef (63). The artificial membrane that was originally made of phospholipids (56,109) can also be as simple as an organic solvent (110) or a mixture of solvents (111).…”

Section: Global Permeation Process (Active + Passive) With Specific Imentioning

confidence: 99%

Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research

et al. 2013

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The drug discovery process for drugs that target the central nervous system suffers from a very high rate of failure due to the presence of the blood-brain barrier, which limits the entry of xenobiotics into the brain. To minimise drug failure at different stages of the drug development process, new methodologies have been developed to understand the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of drug candidates at early stages of drug development. Additionally, understanding the permeation of drug candidates is also important, particularly for drugs that target the central nervous system. During the first stages of the drug discovery process, in vitro methods that allow for the determination of permeability using high-throughput screening methods are advantageous. For example, performing the parallel artificial membrane permeability assay followed by cell-based models with interesting hits is a useful technique for identifying potential drugs. In silico models also provide interesting information but must be confirmed by in vitro models. Finally, in vivo models, such as in situ brain perfusion, should be studied to reduce a large number of drug candidates to a few lead compounds. This article reviews the different methodologies used in the drug discovery and drug development processes to determine the permeation of drug candidates through the blood-brain barrier.

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Evaluation of Intestinal Absorption of Ginsenoside Rg1 Incorporated in Microemulison Using Parallel Artificial Membrane Permeability Assay

Cited by 22 publications

References 32 publications

Pharmacology of ginsenosides: a literature review

Pharmacology of ginsenosides: a literature review

A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders

Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research

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