Evaluation of intervertebral disc degeneration using T2 signal ratio on magnetic resonance imaging

Kamei, Naosuke; Nakamae, Toshio; Nakanishi, Kazuyoshi; Tamura, Takayuki; Tsuchikawa, Yuji; Morisako, Taiki; Harada, Takahiro; Maruyama, Toshiaki; Adachi, Nobuo

doi:10.1016/j.ejrad.2022.110358

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…The T2-weighted MR imaging provides qualitative assessments of the IVD. 51 However, a more detailed analysis can be performed by using histochemistry data.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…After implantation of PLGA and PLGA/CS MS without attached BM-MSC, the MRI signal intensity after 4 weeks from cell-biomaterial transplantation was around 45% (Figure S10, Supporting Information). The T2-weighted MR imaging provides qualitative assessments of the IVD . However, a more detailed analysis can be performed by using histochemistry data.…”

Section: Resultsmentioning

confidence: 99%

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Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Nakielski,

Rybak,

Jezierska-Woźniak

et al. 2023

ACS Appl. Mater. Interfaces

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“…The T2-weighted MR imaging provides qualitative assessments of the IVD. 51 However, a more detailed analysis can be performed by using histochemistry data.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Nakielski,

Rybak,

Jezierska-Woźniak

et al. 2023

ACS Appl. Mater. Interfaces

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“…The enhanced and chronic inflammation of the degenerated IVD is evidenced by the increased secretion of pro-inflammatory cytokines [i.e., interleukin (IL)-1β and -6 and tumor necrosis factor (TNF)-α]. Macroscopically, degenerated IVDs present disruption of the lamellar structure of collagen fibers in the AF, loss of demarcation between the AF and the NP, fissures in both the AF and the NP, dehydration and reduced disc height [ 14 ], rendering X-ray imaging for the estimation of disc space narrowing, Pfirrmann grading system for Τ1ρ-, T2- and T2*-weighted magnetic resonance imaging (MRI) and histological scoring the most common methods for the qualitative evaluation of IDD [ 15 , 16 , 17 ].…”

Section: Intervertebral Disc—intervertebral Disc Degenerationmentioning

confidence: 99%

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Mavrogonatou,

Kletsas

2024

Metabolites

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Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and their senescence-associated secretory phenotype (SASP) has been connected with qualitative/quantitative alterations in the extracellular matrix and ultimately with the disturbance of tissue homeostasis. Given that selective elimination of senescent cells (by the so-called senolytics) or amendment of their secretome towards a less catabolic/inflammatory phenotype (by molecules known as senomorphics) has been reported to alleviate symptoms of several age-associated diseases and to improve tissue quality during aging, here we will review the emerging role of senolytic and senomorphic agents derived from plants and natural products against intervertebral disc degeneration. The mode of action of these senotherapeutics, as well as the challenges in their practical application, will also be explicitly discussed in an attempt to direct their more targeted and effective use in exclusive or combinatorial therapeutic schemes for the prevention and/or treatment of disc degenerative disorders.

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A novel quantitative method to evaluate lumbar disc degeneration: MRI histogram analysis

Li,

Wu,

Liu

et al. 2024

Eur Spine J

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Evaluation of intervertebral disc degeneration using T2 signal ratio on magnetic resonance imaging

Cited by 4 publications

References 20 publications

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

A novel quantitative method to evaluate lumbar disc degeneration: MRI histogram analysis

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