Evaluation of Injectable Strontium-Containing Borate Bioactive Glass Cement with Enhanced Osteogenic Capacity in a Critical-Sized Rabbit Femoral Condyle Defect Model

Zhang, Yadong; Cui, Xu; Zhao, Shichang; Wang, Hui; Rahaman, Mohamed N.; Liu, Zhongtang; Huang, Wenhai; Zhang, Changqing

doi:10.1021/am507008z

Cited by 71 publications

(61 citation statements)

References 55 publications

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“…This underscores the local release and clearance of strontium from the site and encourages the case for PPCN‐Sr as a safe macromolecule clinically. Of the in vivo Sr‐biomaterial literature, only two studies used injectable systems and none of the materials were inherently antioxidant—the first was the study by Lourenco et al which employed 100 mM Sr‐doped HA‐alginate microspheres and the second incorporated 9 mol % SrO in borate bioactive glass . The majority of the other materials used were calcium phosphate‐based, doped with HA, or variants of bioactive glass .…”

Section: Discussionmentioning

confidence: 99%

A thermoresponsive, citrate‐based macromolecule for bone regenerative engineering

Morochnik

Zhu

Duan

et al. 2018

J Biomedical Materials Res

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There is a need in orthopaedic and craniomaxillofacial surgeries for materials that are easy to handle and apply to a surgical site, can fill and fully conform to the bone defect, and can promote the formation of new bone tissue. Thermoresponsive polymers that undergo liquid to gel transition at physiological temperature can potentially be used to meet these handling and shape-conforming requirements. However, there are no reports on their capacity to induce in vivo bone formation. The objective of this research was to investigate whether the functionalization of the thermoresponsive, antioxidant macromolecule poly(poly-ethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN), with strontium, phosphate, and/or the cyclic RGD peptide would render it a hydrogel with osteoinductive properties. We show that all formulations of functionalized PPCN retain thermoresponsive properties and can induce osteodifferentiation of human mesenchymal stem cells without the need for exogenous osteogenic supplements. PPCN-Sr was the most osteoinductive formulation in vitro and produced robust localized mineralization and osteogenesis in subcutaneous and intramuscular tissue in a mouse model. Strontium was not detected in any of the major organs. Our results support the use of functionalized PPCN as a valuable tool for the recruitment, survival, and differentiation of cells critical to the development of new bone and the induction of bone formation in vivo. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1743-1752, 2018.

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Section: Discussionmentioning

confidence: 99%

A thermoresponsive, citrate‐based macromolecule for bone regenerative engineering

Morochnik

Zhu

Duan

et al. 2018

J Biomedical Materials Res

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“…In clinic use, setting time, injectability and disintegration resistance are key characteristics for bone cements 22, 23 . According to the results showed in section 3.1, the PSC/CS cement showed excellent injectabiliy (>90%) and stayed homogeneous throughout the whole injection process.…”

Section: Discussionmentioning

confidence: 99%

Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation

Zhu

Ren

et al. 2017

Sci Rep

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Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS composite cement with high content of PSC (a phytic acid-derived bioactive glass) was prepared and evaluated in both vitro and vivo. The PSC/CS cement showed excellent injectability, good resistance to disintegration, radiopacity and suitable mechanical properties. The in vitro test showed that the cement was bioactive, biocompatible and could maintain its shape sustainably, which made it possible to provide a long-term mechanical support for bone regeneration. Radiography, microcomputed tomography and histology of critical sized rabbit femoral condyle defects implanted with the cements proved the resorption and osteoinductivity of the cement. Compared with the PMMA and CSPC, there were more osteocyte and trabeculae at the Bone-Cement interface in the group PSC/CS cement. The volume of the residual bone cement suggested that PSC/CS had certain ability of degradation and the resorption rate was much lower than that of the CSPC cement. Together, the results indicated that the cement was a promising bone cement to treat the VCFs.

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“…In addition, our research group had successfully prepared an injectable BBGC with excellent performance. However, the vivo implanting results indicated that the BBG's degradation behavior was poor, and only a small amount of newly bone formed on the surface of the implant [2,9] . Based on the above rationale, we speculated that the introduction of macropores into BBGC can improve its degradation ability and accelerate mineralization rate.…”

mentioning

confidence: 99%

“…Due to the advantages of excellent biocompatibility, degradability and osteoconductivity, borate bioactive glass (BBG) has attracted great interests in bone tissue engineering over the past decades. Specifically, BBG particles can react with body fluids and form a HA surface layer that bonds strongly to bone and soft tissue [1][2] . So far, BBG was mainly used in the form of scaffolds [3] and granules [4] , but little work has been done to study the fabrication of borate bioactive glass cement (BBGC) .…”

mentioning

confidence: 99%

Effect of Gas-foaming Porogen-NaHCO$lt;inf$gt;3$lt;/inf$gt; and Citric Acid on the Properties of Injectable Macroporous Borate Bioactive Glass Cement

Wu¹,

Song²,

Yao³

et al. 2017

Journal of Inorganic Materials

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Borate bioactive glass (BBG) is a promising candidate material for bone tissue engineering. Mostly, it was applied in the form of scaffolds and granules. Till now, little work has been done to investigate the fabrication of porous borate bioactive glass cement (BBGC). In this work, we prepared an injectable macroporous BBGC via gas-foaming method, where NaHCO 3 and citric acid were used as porogen. Porous structure was analyzed by using SEM. The properties of soaking products were characterized by XRD, FTIR and ATR. The injection test showed that the injection rate of BBGC was over 80%. SEM images presented that there were apparent pores in BBGC. The diameter of the macropores varied from 10 μm to 800 μm. Furthermore, the degradability of BBGC was greatly improved. After one month in vitro soaking, the weight loss of non-foamed BBGC was only 50wt%, while for the foamed samples, their weight loss reached 70wt%. Meanwhile, the XRD, FTIR and ATR results exhibited that there were hydroxyapatite (HA) formation and confirmed that the introduction of macropores into the BBGC did facilitate the mineralization reaction.

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Evaluation of Injectable Strontium-Containing Borate Bioactive Glass Cement with Enhanced Osteogenic Capacity in a Critical-Sized Rabbit Femoral Condyle Defect Model

Cited by 71 publications

References 55 publications

A thermoresponsive, citrate‐based macromolecule for bone regenerative engineering

A thermoresponsive, citrate‐based macromolecule for bone regenerative engineering

Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation

Effect of Gas-foaming Porogen-NaHCO$lt;inf$gt;3$lt;/inf$gt; and Citric Acid on the Properties of Injectable Macroporous Borate Bioactive Glass Cement

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