Evaluation of Injectable Platelet Rich Fibrin (I-PRF) with Bone graft around Immediate Dental Implant in Esthetic Zone

Abstract

Purpose: Injectable Platelet Rich Fibrin (I-PRF) is an efficient method in periodontal wound healing and regenerating bone; thus, the purpose of the current research was to assess radiographic and clinical of I-PRF around the immediate dental implant in the esthetic zone with xenograft. Material and methods: Twelve patients with unrestorable tooth/teeth in the esthetic zone were selected. Patients were selected randomly and split into two groups; Group I (test group; n = 6) patients that received immediate implant placement using I-PRF and xenograft and Group II (control group; n = 6) patients that established immediate implant placement with xenograft only. Clinically, the pain was evaluated for each patient by using the visual analog scale (VAS). Assessment of healing progress was conducted by modified gingival index (MGI)and modified plaque index (MPI) at 1 st , 3 rd , and 6 th months after implant placement. Radiography, the assessment of osteointegration, can be conduct by bone density at 1 st and 6 th month after implant placement. Results: Regarding the change in both MPI and MGI, there was statistically a significant difference. The study group showed a higher Change than the control group. At 1,3 and 7 days, there was a statistically non-significant difference in mean VAS in the two groups P=0.18. Regarding Change in Bone Density, the study group showed a higher Change than the control group with a statistically significant difference(P=0.002). Conclusion: The use of I-PRF with immediate dental implant placement offers a new promising safe, compatible, and effective method for managing the healing process around immediate dental implants.

Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects. “Randomized Controlled Trial”

“…Similarly, Reda et al, evaluated the benefit of adding i-PRF to xenograft around immediate implants. 6 months postoperatively, they recorded mean change in bone density in the group which received i-PRF and xenograft 154.16±42.44 versus 74.83±19.31 in the group which received only xenograft with a statistical significant difference in favor of the test group (35) . The increase in bone density in the present study and the previously mentioned ones may be justified by the conclusion stated by Wang et al, who observed that i-PRF has a noticeable effect on osteoblasts migration, differentiation, activation, proliferation and survival rate.…”