Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Abstract

The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of Japanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.

Case report on the use of a honey on diabetic foot ulcer patients

“…Many studies have reported the effectiveness of honey in the management of wounds (Bang, Buntting, & Molan, 2003;Haryanto et al, 2012;Mohammadi et al, 2013;Surahio et al, 2014). Our case report showed that the use of honey dressing could control the infection of the wounds.…”

“…Honey has shown its effectiveness against two serious bacteriaproducing problems, namely methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Honey has an antibacterial activity that could be seen to be effective in preventing the growth of bacteria on the surface of a wound even after a tenfold dilution of the honey with the secretions from the wound (Haryanto et al, 2012;Surahio et al, 2012). Furthermore, prolonged use of honey in wound dressing does not lead to drug resistance as seen in the use of antibiotics.…”

Study Literature Peran Epidermal Growth Factor dalam Proses Penyembuhan Luka

“…Penelitian yang telah dilakukan Diaz, Torregrosa, Benítez, Mercado, & Fiorentino (2012) penggunaan complementary alternative medicine (CAM) berbasis tanaman (herbal dan buah-buahan) bahwa 65% dari pasien memiliki persepsi keseluruhan yang posisitf tentang kondisi mereka dan bahkan menunjukkan peningkatan kesehatan. Terapi komplementer sering digunakan antara lain madu (Haryanto et al, 2012;Mukai et al, 2015), minyak kelapa (Tarawan, Mantilidewi, Dhini, Radhiyanti, & Sutedja, 2017), daun sirih (Maryunis, 2017), dan buah naga merah (Tahir et al, 2017). Salah satu terapi komplementer yang direkomendasikan saat ini adalah buah naga merah.…”

Maxillary Growth Evaluation Of Patients With Unilateral Complete Cleft Lip And Palate After Two Flap Palatoplasty With Honey Oral Drops

“…2 The role of honey in precipitating epithelialization had been proven from previous studies. [3][4][5][6][7][8][9][10][11] An experimental study by Haryanto, et al in 2012 demonstrated that honey reduce inflammation and wound contraction. Wound re-epithelialization with Indonesian honey reached 26%, 68%, 69%, and 100% on day 3, 7, 11, 14, respectively.…”

“…Wound re-epithelialization with Indonesian honey reached 26%, 68%, 69%, and 100% on day 3, 7, 11, 14, respectively. 7 Other factors that may impair maxillary growth include timing of l i p s u r g e r y , p a l a t a l s u r g e r y a n d g i n g i v o a l v e o l o p l a s t y, n u t r i t i o n a l s t a t u s , congenitally missing lateral incisors, and family history of maxilla hypoplasia. [12][13] In order to discover the long term effect of honey drops and the rapid epithelialization it caused on lateral palatal defect following two flap palatoplasty, we analyzed the maxillary growth of UCCLP patients who underwent palatoplasty with honey oral drops compared to the UCCLP patients without honey oral drops in 2011.…”