Study Literature Peran Epidermal Growth Factor dalam Proses Penyembuhan Luka

Febrianti, Nur; Tahir, Takdir; Yusuf, Saldy

doi:10.30651/jkm.v4i1.1852

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…The bFGF is a growth factor secreted by fibroblasts for tissue repair, epithelial regeneration, and remodeling. (17) Previous studies have shown that human mesenchymal stromal cells (hMSCs) reduce FGF receptor 1 (FGFR1) expression, leading to unresponsiveness to bFGF, whereas fibroblasts maintain high FGFR1 expression. In hMSCs and fibroblasts, inhibition of actin-myosin interaction and MRTF/SRF activity decreases FGFR1 expression.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts

Hidayati,

Kusuma,

Poerwanto

2023

Univ Med

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BACKGROUNDHuman dermal fibroblast (HDF) cultures can be used as a regenerative agent for wound healing. Fetal bovine serum (FBS) as a culture supplement is derived from animals, therefore not being constant in composition, causes variations in research results, thus requiring a substitute such as KnockOut serum replacement (KOSR). This study evaluated the defined KOSR as FBS substitute for HDF culture by measuring the relative expression of basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF) messenger RNA (mRNA), HDF cell proliferation, and HDF migration. METHODSHuman dermal fibroblast culture was divided into 2 intervention groups receiving KOSR 5% and KOSR 10%, respectively, and a control group receiving FBS 10%. Reverse transcription polymerase chain reaction (RT-PCR) was used for bFGF and KGF mRNA relative expression at the fifth passage (P5). Cell counting kit-8 (CCK-8) reagent was used for the HDF cell proliferation assay at P5 and the scratch assay was used for HDF cell migration at P6. Data were analyzed using dependent t-test, One-way ANOVA, or Kruskal-Wallis test. RESULTSThere were no significant differences in bFGF and KGF mRNA relative expression and HDF migration velocity between the intervention and control groups (p>0.05 and p>0.05, respectively). The doubling time of the KOSR 5% group showed no significant difference (p>0.05), but KOSR 10% and FBS 10% showed significant differences between treatment days 2-6 and treatment days 6-10 (p<0.05). CONCLUSIONSThe KOSR 10% was comparable to FBS 10% in supporting bFGF and KGF mRNA relative expression, HDF cell proliferation, and HDF cell migration in HDF culture.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts

Hidayati,

Kusuma,

Poerwanto

2023

Univ Med

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“…Kondisi ini juga diungkapkan dalam temuan lain yang membahas dampak penandaan stoma site pada saat preoperatif dapat meningkatkan perawatan diri dan kualitas kesehatan pasien (Kim, Jang, dan Lee 2021). Berbagai pendekatan telah dilakukan untuk meningkatkan pengetahuan pasien diantaranya melalui media video (Salmawati, Yusuf, and Tahir 2019). Pendekatan edukasi berbasis video dilaporkan efektif pada kasus kaki diabetes (Hamzah, Yusuf, and Iswanti Afelya 2020).…”

Section: Pembahasanunclassified

Gambaran Pengetahuan dan Keterampilan Pasien dengan Stoma Abdomen dalam melakukan Perawatan Stoma secara Mandiri: Scoping Review

Ul Husna,

Yusuf,

Majid

2024

JOND

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Pasien dengan stoma cenderung mengalami hambatan dalam melakukan perawatan secara mandiri sehingga menimbulkan beberapa masalah diantaranya rasa malu akibat kebisingan kantong, gas dan bau, ketakutan terhadap kebocoran kantong serta komplikasi berupa rasa nyeri dan ekskoriasi kulit di sekitar lokasi stomal, diare stomal atau konstipasi dan enema. Studi ini bertujuan mengetahui gambaran tingkat pengetahuan dan keterampilan pasien dengan stoma abdomen (kolostomi dan ileostomi) dalam melakukan perawatan stoma mandiri serta metode edukasi yang digunakan. Penelitian ini merupakan penelitian literatur dengan desain scoping review pada 4 database: PubMed, Sciencedirect, DOAJ dan Ebscho dengan kata kunci Self Care AND skill OR knowledge AND Colostomi OR ostomi OR ostomate OR Ileostomi serta penyaringan artikel menggunakan aplikasi Mendeley pada rentang tahun 2017-2022 dan didapatkan sebanyak 7 artikel. Hasil penelitian dari 7 artikel yang diperoleh, pasien dengan ostomi baru pasca pembuatan stoma memiliki tingkat pengetahuan yang kurang terhadap perawatan diri pada periode postoperative akibat dampak dari perubahan pada kondisi fisik serta emosionalnya dan meningkat seiring dengan intervensi perawatan dan keterlibatan pasien dalam merawat stomanya. Selain itu, pasien ostomi secara umum memiliki keterampilan dalam pengosongan dan penggantian kantong stoma, perawatan kulit peristomal serta modifikasi diet. Dalam proses memperoleh pengetahuan, ostomate memerlukan keterlibatan keluarga dan tenaga kesehatan serta edukasi yang sesuai dengan kebutuhan ostomate.Patients with a stoma tend to experience obstacles in carrying out treatment independently, which causes several problems, including embarrassment due to bag noise, gas, and odor, fear of bag leakage, and complications in the form of pain and skin excoriation around the stomal location, stomal diarrhea or constipation, and enemas. This study aims to determine the level of knowledge and skills of patients with abdominal stomas (colostomies and ileostomies) in carrying out independent stoma care and the educational methods used. This research is a literature study with a scoping review design on 4 databases: PubMed, ScienceDirect, DOAJ, and Ebscho, with the keywords Self Care AND skill OR knowledge AND Colostomi OR ostomi OR ostomate OR Ileostomi, as well as filtering articles using the Mendeley application in the period 2017–2022. There were 7 articles obtained. The results of the research from the 7 articles obtained showed that patients with a new ostomi after stoma creation had a poor level of knowledge regarding self-care in the postoperative period due to the impact of changes in their physical and emotional conditions, and this increased along with treatment interventions and patient involvement in caring for their stoma. In addition, ostomi patients generally have skills in emptying and changing the stoma bag, peristomal skin care, and diet modification. In the process of gaining knowledge, ostomates need the involvement of family and health workers, as well as education that suits the ostomate's needs.

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“…Hasil penelitian lainnya menyebutkan bahwa pemberian edukasi menggunakan multimedia lebih signifikan meningkatkan pengetahuan dan keterampilan ostomate dibandingkan dengan edukasi konvensional (Wang et al, 2021). Pemberian edukasi menggunakan video secara signifikan dapat meningkatkan pengetahuan dan kemampuan pasien tentang cara perawatan stoma (Salmawati et al, 2019). Penelitian pendukung lain mengenai edukasi ostomate menyebutkan bahwa penggunaan aplikasi seluler terbukti memberikan efek lebih baik terhadap kemampuan merawat stoma sendiri dan kepuasan terhadap edukasi yang diberikan dibandingkan dengan pasien yang diedukasi menggunakan booklet (Yiğitoğlu & Şendir, 2021).…”

Section: Penelitian Fase IIIunclassified

Pengembangan Model Edukasi Pelaksanaan Discharge Planning Berbasis Telenursing untuk Meningkatkan Self Care Management Ostomate

Selpawani,

Yusuf,

Syahrul

et al. 2023

JOTING

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The purpose of this research is to develop an educational model for implementing discharge planning by utilizing telenursing through creating video content using the METHOD (Medication, Environment, Treatment, Health teaching, Outpatient referral, Diet) approach to improve ostomate self-care management. The research method used was the Delphi studi and this research was conducted in three phases, namely a literature review related to the content and educational model of discharge planning, video content development using the Delphi study accompanied by an evaluation of the validity of the video content by experts, and a pilot study to evaluate the ability of self care management ostomate using the Self Care Agency Scale (SCAS) questionnaire. The research result obtained 17 educational discharge planning items were obtained from the results of the literature review and the Delphi study which were used as video content. The results of the evaluation after the educational intervention showed that there was a significant increase in ostomate self-care management skills (p = 0.000). In conclusion, discharge planning education based on telenursing which is based on the METHOD approach, and provided in video form can be one of the recommendations for interventions in nursing practice to improve ostomate self care management. Keywords: Discharge Planning Education, Ostomate, Self Care Management

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Study Literature Peran Epidermal Growth Factor dalam Proses Penyembuhan Luka

Cited by 4 publications

References 16 publications

Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts

Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts

Gambaran Pengetahuan dan Keterampilan Pasien dengan Stoma Abdomen dalam melakukan Perawatan Stoma secara Mandiri: Scoping Review

Pengembangan Model Edukasi Pelaksanaan Discharge Planning Berbasis Telenursing untuk Meningkatkan Self Care Management Ostomate

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