“…Rather, ICG appeared to describe the performance of the liver independent of the actual presence of the cirrhotic complications and the subsequent therapeutic interventions as proven in the second cohort undergoing immediate TIPS implantation. Thus, the modified MELD-ICG will not improve on the MELD in patients with advanced liver failure (MELD >35) and high short-term mortality, as recently demonstrated in another cohort 25. Its strength appears to lie in predicting survival in intermediate to advanced disease, similar to the MELD-Na (table 4), but it is still accurate when parameters like creatinine and sodium might be adjusted through treatment such as TIPS.…”