Increased Frequency of Circulating Th17 Cells in Acute-on-Chronic Hepatitis B Liver Failure

Wang, Liyuan; Meng, Qingying; Zou, Zhiqiang; Fan, Yu–Chen; Han, Jie; Zhang, Qi; Ge, Jian; Xu, Ai-Ling; Wang, Sikui; Wang, Kai

doi:10.1007/s10620-011-1930-5

Cited by 18 publications

(10 citation statements)

References 40 publications

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“…In addition to T follicular help (TFH) cells, interleukin-17-producing CD4+ T cells (Th17) also secrete IL-21 [24,25]. The highly increased frequency of Th17 cells in PBMCs has been observed in CHB patients with severe liver damage [25,26]. So the increased IL-21-secreting CD4 T cells might not be mainly derived from TFH cells, but also from Th17 cells in hepatitis B-related acute-on-chronic liver failure and severe chronic hepatitis B as Hu's report demonstrating IL-21 mainly derived from IL-17A+ IL-21+ CD4+ T cells [22].…”

Section: Discussionmentioning

confidence: 99%

HBcAg‐Specific IL‐21‐Producing CD4+ T Cells are Associated with Relative Viral Control in Patients with Chronic Hepatitis B

Liu

Cheng

et al. 2013

Scand J Immunol

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Function exhaustion of specific cytotoxic CD8+ T cell in chronic virus infection partly results from the low levels of CD4 help, but the mechanisms by which CD4 help T cell required to control hepatitis B virus infection are not well understood. In this study, we investigated the role of interleukin-21-producing CD4+ T cell response in viral control of hepatitis B virus infection. HBcAgspecific interleukin-21-producing CD4+ T cells in blood were detected in patients with hepatitis B virus infection. Patients with acute hepatitis B had greater HBcAg-specific interleukin-21-producing CD4+ T cells in blood compared with chronic hepatitis B patients, and there was no statistical significance between immune active chronic hepatitis B patients and inactive healthy carrier patients for these cells, whereas frequencies of these cells negatively correlated with HBV DNA levels but positively correlated with HBc18-27-specific IFN-c-producing CD8+ T cells. Moreover, interleukin-21 sustained HBc18-27-specific CD8+ T cells in vitro, and interleukin-21 production by HBcAg-specific IL-21-producing CD4+ T cells of acute hepatitis B patients enhanced IFN-c and perforin expression by CD8+ T cells from chronic hepatitis B patients. Our results demonstrate that HBcAg-specific interleukin-21-producing CD4+ T cell responses might contribute to viral control by sustaining CD8+ T cell antiviral function.

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Section: Discussionmentioning

confidence: 99%

HBcAg‐Specific IL‐21‐Producing CD4+ T Cells are Associated with Relative Viral Control in Patients with Chronic Hepatitis B

Liu

Cheng

et al. 2013

Scand J Immunol

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“…At the same time, Th17/IL-17 axis expresses itself, a response to a sustained proinflammatory stimulus ( 51 , 52 ). So, we can understand the broad scope of the elements of this axis on the CVH, predicting outcomes in different points of the disease, from spontaneous healing ( 53 ), response to treatment ( 23 , 54 , 55 ), occurrence of acute decompensations ( 56 ), progression to cirrhosis ( 9 , 28 ), and HCC ( 53 ), including post-transplant recurrence ( 57 ), as detailed in this section.…”

Section: The Th17/il-17 Axis and Outcome Prediction In Cvhmentioning

confidence: 99%

“…Beyond its effect in predicting disease severity, the Th17/IL-17 axis elements are also predictors of mortality ( 56 ). In a study including 60 HBV-infected patients (30 with CHB and 30 with ACLF), the disproportionate increase of Th17 (compared to Treg) was associated with low survival among those with ACLF ( 64 ).…”

Section: The Th17/il-17 Axis and Outcome Prediction In Cvhmentioning

confidence: 99%

Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis

Paquissi

2017

Front. Immunol.

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Cirrhosis is a common final pathway for most chronic liver diseases; representing an increasing burden worldwide and is associated with increased morbidity and mortality. Current evidence has shown that, after an initial injury, the immune response has a significant participation in the ongoing damage, and progression from chronic viral hepatitis (CVH) to cirrhosis, driving the activation and maintenance of main fibrogenic pathways. Among immune deregulations, those related to the subtype 17 of T helper lymphocytes (Th17)/interleukin-17 (IL-17) axis have been recognized as key immunopathological and prognostic elements in patients with CVH. The Th17/IL-17 axis has been found involved in several points of fibrogenesis chain from the activation of stellate cells, increased expression of profibrotic factors as TGF-β, promotion of the myofibroblastic or epithelial–mesenchymal transition, stimulation of the synthesis of collagen, and induction of imbalance between matrix metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs). It also promotes the recruitment of inflammatory cells and increases the expression of proinflammatory cytokines such as IL-6 and IL-23. So, the Th17/IL-17 axis is simultaneously the fuel and the flame of a sustained proinflammatory and profibrotic environment. This work aims to present the immunopathologic and prognostic role of the Th17/IL-17 axis and related pathways in fibrogenesis and progression to cirrhosis in patients with liver disease due to hepatitis B virus (HBV) and hepatitis C virus (HCV).

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“…Th17 levels [141, 142] and the Treg/TH17 ratio appear to have a crucial role in the occurrence, development, and outcome of HBV [142, 143] and could be used as indicators of inflammation that may predict progression to fibrosis [144]. Hence, Th17 cells can contribute to immune activation and disease aggravation in patients with chronic HBV infection [138, 145], because of the correlation of Th17 cells with serum alanine aminotransferase levels [139].…”

Section: Th17 Cells In Autoimmune and Infectious Diseasesmentioning

confidence: 99%

Th17 Cells in Autoimmune and Infectious Diseases

Zambrano‐Zaragoza

Romo-Martínez

Durán‐Avelar

et al. 2014

International Journal of Inflammation

151

125

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The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.

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Increased Frequency of Circulating Th17 Cells in Acute-on-Chronic Hepatitis B Liver Failure

Abstract: These results suggested that Th17 cells as well as IL-17 might be related with disease severity and prognosis in ACHBLF patients.

Cited by 18 publications

References 40 publications

HBcAg‐Specific IL‐21‐Producing CD4+ T Cells are Associated with Relative Viral Control in Patients with Chronic Hepatitis B

HBcAg‐Specific IL‐21‐Producing CD4+ T Cells are Associated with Relative Viral Control in Patients with Chronic Hepatitis B

Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis

Th17 Cells in Autoimmune and Infectious Diseases

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