Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus

Kilani-Jaziri, Soumaya; Ghedira, Zied; Nasr, Nouha; Krifa, Mounira; Ghedira, Kamel; Genviève, Franca Dijoux Marie; Leila, Ghedira Chekir

doi:10.1016/s1995-7645(14)60004-3

Cited by 35 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[28,49] The protoscolicidal effect of C.rotundus rhizomes may be related to the alkaloids compound, others workers proved the action of alkaloids in Sophora mooreroffiana seeds which showed efficiency against E.granulosus protoscoleces. [50] Moreover Soumaya et al, [33] showed in phytochemical study of C.rotundus extracts the presence of total poly phenol, flavonoids compounds and tannins, also they identified orientin as one among other flavonoids and they considered it has potential role in biological activity of the extracts and it may be influence the antioxidant and apoptotic activity specifically in the alcoholic extract. [51] In the present study, as far as the extracts were as crude form and probably contain many compounds which may act synergistically, so it is difficult to decide which compound is responsible for the protoscolicidal effect.…”

Section: -Discussionmentioning

confidence: 99%

“…[42,61,62] Regarding C. rotundus and within this hypothesis, recent studies concluded that the aerial parts extract of this plant exhibit a potential use as antioxidant and apoptosis inducer and explained that the anti-proliferative effect of these extracts is due to induction of apoptosis and suggested the regulation of apoptotic genes may be controlled by their phenolic content, orientin is one of the main flavonoids identified in alcoholic extract. [33] Moreover, the result of Hu et al, [63] confirmed the presence of apoptosis and the existence of CED-3 like apoptotic gene in protoscoleces of E. granulosus and proved that H2O2and hexamenthasone can induce cell apoptosis of protoscoleces in drug-induced apoptosis mechanisms.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 93%

“…Other phytochemical study on C.rotundus showed that the extracts exhibited antioxidant and an apoptosis inducer. [33] In addition, the tubers and rhizomes of C. rotundus have been used in perfumes, spices and Ayurvedic remedies in Arab countries, Africa, China and India for centuries. Its tubers have long been used as a natural remedy to cure spasms, diarrhoea, dysmenorrhea and menstrual irregularities.…”

Section: Cyperus Rotundusmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa¹

2017

WJPR

View full text Add to dashboard Cite

show abstract

Section: -Discussionmentioning

confidence: 99%

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 93%

Section: Cyperus Rotundusmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa¹

2017

WJPR

View full text Add to dashboard Cite

show abstract

“…Phenolic compounds are very important plant constituents because they exhibit an antioxidant activity by inactivating lipid free radicals or preventing decomposition of hydroperoxides into free radicals. 21 The antioxidant potential of the extracts were determined by five methods namely DPPH assay, super oxide radical scavenging assay, nitric oxide radical scavenging assay, hydroxyl radical scavenging assay and reductive assay; cytotoxic activity was studied by using trypan blue exclusion method.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activity of Different Extracts of Zanthoxylum Alatum

et al. 2015

View full text Add to dashboard Cite

Objectives: The present study evaluates the antioxidant and cytotoxic activity of different extract (methanol, chloroform, petroleum ether) of Zanthoxylum alatum. Methodology: The antioxidant activities of all the three above mentioned extracts of Zanthoxylum alatum were measured by different in vitro standard methods like 1,1-diphenyl-2-picrylhydrazil radical (DPPH), superoxide anions, nitric oxide, hydroxyl radicals and reductive assay. On the basis of antioxidant properties total phenolic, total flavonoid, CCl 4 -induced in vivo antioxidant and in vitro cytotoxicity were measured for methanol extract of Zanthoxylum alatum (MEZA). Cytotoxicity was determined in Ehrlich Ascites Cancer (EAC) cells by trypan blue exclusion method. Results: The extracts exhibited antioxidant activities in a dose dependent manner. The IC 50 values of Methanol, Chloroform, Petroleum ether extracts and standard for DPPH are 3.63 ± 0.14 μg/mL, 9.33 ± 0.42 μg/mL, 7.70 ± 0.31 μg/mL and 7.87 ± 0.39 μg/mL; for Superoxide are 19.80 ± 0.96 μg/mL, 129.70 ± 2.57 μg/mL, 168.10 ± 2.26 μg/mL and 11.76 ± 0.72 μg/mL; for Nitric oxide are 105.0 ± 1.64 μg/mL, 157.60 ± 1.99 μg/mL, 185.30 ± 2.48 μg/mL and 28.48 ± 1.06 μg/mL; for Hydroxyl radical are 28.10 ± 0.75 μg/mL, 81.50 ± 1.88 μg/mL, 72.47 ± 1.76 μg/mL and 12.24 ± 0.82 μg/mL. Reductive ability of the extracts was also tested where dose dependent reducing capability was observed. In case of in vivo antioxidant lipid peroxidation, reduced glutathione, superoxide dismutase and catalase parameters significantly change towards the normal levels. MEZA showed satisfactory phenolic and flavonoid content which support the cytotoxicity with IC 50 value 102.30 ± 0.81 μg/mL. Conclusion: The study showed that among all the three extract MEZA has better dose dependant antioxidant and cytotoxic activity. Further research is going on to find out the active principle(s) of MEZA for its cytotoxic activity.

show abstract

“…The phytochemical constituents of C. rotundus and Z. officinale have been studied extensively. C. rotundus contains quercetin, kaempferol, alkaloids, flavonoids, tannins, starch, glycosides, chalcones, gallic acid and p-coumaric acid [9, 10]. Z. officinale includes gingerol, paradols, and shogaol [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective and cognitive-enhancing effects of the combined extract of Cyperus rotundus and Zingiber officinale

Sutalangka

Wattanathorn

2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundCurrently, food supplements to improve age-related dementia are required. Therefore, we aimed to determine the effect of the combined extract of Cyperus rotundus and Zingiber officinale (CP1) on the improvement of age-related dementia in rats with AF64A-induced memory deficits.MethodsMale Wistar rats weighing 180-200 g were orally given CP1 at doses of 100, 200 and 300 mg.kg-1 BW for a period of 14 days after bilateral intracerebroventricular administration of AF64A. Spatial memory was assessed in all rats every 7 days throughout the 14 day-experimental period. At the end of the study, neuronal density, acetylcholinesterase (AChE) activity, oxidative stress status and the activation of MAPK cascades in the hippocampus were determined.ResultsEnhanced memory, increased neuronal density, decreased AChE activity and decreased oxidative stress status together with activated pERK1/2 were observed in the hippocampus of CP1-treated rats. These results suggested that CP1 might improve memory via enhanced cholinergic function and decreased neurodegeneration and oxidative stress.ConclusionsCP1 is a potential novel food supplement for dementia. However, further investigations on the subchronic toxicity of CP1 and drug interactions are required.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1632-4) contains supplementary material, which is available to authorized users.

show abstract

Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus

Abstract: It appears that C. rotundus extracts exhibit a potential use as a natural antioxidant and an apoptosis inducer.

Cited by 35 publications

References 41 publications

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Antioxidant and Cytotoxic Activity of Different Extracts of Zanthoxylum Alatum

Neuroprotective and cognitive-enhancing effects of the combined extract of Cyperus rotundus and Zingiber officinale

Contact Info

Product

Resources

About