Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa, Bushra Hussain

doi:10.20959/wjpr20178-9053

Cited by 7 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to previous studies, the treated protoscoleces with plant material or bile acid-like chenodeoxycholic acid displayed decreased viability as well as morphological alterations, including the soma region contracting, bleb development, rostellar disorganization, loss of the parasite hooks, the obliteration of microtriches, and the formation of vesicles and lipid droplets (Shi et al 2016;Shnawa et al 2017). Additionally, since microtriches are directly linked to nutrition absorption, the structural changes of the tegument affect the microtriches, which may interfere with protoscoleces nutrition (Xing et al 2016).…”

Section: Proposed Mechanisms Of Actionmentioning

confidence: 89%

The Anti-Echinococcus Potential of Botanicals and Nano Green Particles: Recent Updating

2023

IJAB

View full text Add to dashboard Cite

Section: Proposed Mechanisms Of Actionmentioning

confidence: 89%

The Anti-Echinococcus Potential of Botanicals and Nano Green Particles: Recent Updating

2023

IJAB

View full text Add to dashboard Cite

“…During the surgical procedure, attempting to remove them, injection of a scolicidal material into a hydatid cyst to decrease the risk of leakage from the protoscoleces is a vital step as the spreading of hydatid fluid containing protoscoleces throughout the operation is the main reason for recurrence. 1 Benzimidazole was suggested by the WHO as a treatment for human infection. It is well known that this medication has parasitostatic rather than parasiticidal effects.…”

Section: Introductionmentioning

confidence: 99%

The efficiency of fabricated Ag/ZnO nanocomposite using Ruta chalepensis L. leaf extract as a potent protoscolicidal and anti-hydatid cysts agent

Jalil,

Shnawa,

Hamad

et al. 2023

J Biomater Appl

View full text Add to dashboard Cite

Background As a consequence of their eco-friendliness, simplicity and non-toxicity, the fabrication of metal and metal oxide nanoparticles using greener chemistry has been a highly attractive research area over the last decade. Aim In this study focused on the fabrication of silver-Zinc oxide nanocomposite (Ag-ZnO NCs) using Ruta chalepensis leaf extract and evaluating its potential biological activities, against Echinococcus granulosus in an in vitro and in vivo model using BALB/c mice. Methods In this study, the synthesis of Ag-ZnO NCs was accomplished using local R. chalepensis leaf extracts. The synthesized nanocomposites were identified using UV-Vis, SEM-EDX, XRD, and FTIR. For a short-term assessment of acute toxicity, BALB/c mice were given the prepared NCs orally. Dual sets of mice were also intraperitoneally injected with protoscoleces for secondary echinococcosis infection. Furthermore, a blood compatibility test was carried out on the nanocomposites. Results The synthesized Ag-ZnO NCs presented a surface plasmon peak at 329 and 422 nm. The XRD, SEM, and EDX confirmed the purity of the Ag-ZnO NCs. The FTIR spectra indicated the formation of Ag-ZnO NCs. Compared to the untreated infected mice, the treated-infected animals displayed an alteration in the appearance of the hepatic hydatid cysts from hyaline to whitish cloudy with a rough surface appearance. Lysis of RBCs at various doses of Ag-ZnONCs was significantly less than the positive contro,. Conclusion These findings revealed that the Ag-ZnO NCs didn’t cause any adverse symptoms and no mortality was observed in all administered groups of mice. The obtained outcomes confirmed that concentrations of up to 40 μg/mL of the bio-fabricated Ag-ZnONCs induced no notable harm to the red blood cells.

show abstract

“…Kohansal et al [14] reviewed most literature that achieved results during 1996-2015 and focused on some plant extracts that showed high efficiency against CE. In recent studies, Almalki et al [15] and Shnawa et al [16] investigated the scolicidal effects of Curcuma longa, Zingiber officinale, and Cyperus rotundus extracts respectively. Their results indicated the potential effectiveness of these plants as scolicidal agents against CE.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Use of Nanoparticles as Anti-Cystic Echinococcosis Agents: A Review Article

Shnawa

2018

JPRI

View full text Add to dashboard Cite

Echinococcus granulosus is the etiological agent of cystic echinococcosis, which is globally distributed and considered as a neglected tropical disease. It is one of the most important zoonotic parasitic infections in both humans and animals. This parasite forms hydatid cysts in various organs of numerous hosts including humans. Surgery remains the predominant therapeutic modality, but other methods also play important role in this disease management. Several scolicidal agents are used for inactivation of the protoscoleces within the hydatid cyst during surgery because spillage of hydatid fluid is the major reason for recurrence. Till now, no effective and safe agent is available. Benzimidazole is the only chemical synthetic drug licensed for the treatment of this disease. Usage of this medication is limited owing to its poor water solubility and low bioavailability, as well as its severe adverse effects. As a result, there is a constant motivation toward exploring a novel alternative to prevent the recurrence rate of the disease and to overcome the side effects of synthetic therapy. The current review focuses on the recent efforts toward obtaining better scolicidal compounds including the achievements in the frontiers of Nanomedicine technique. This review highlights the result of newer therapeutic attempts such as, the introducing of biogenic selenium, silver, gold and chitosan nanoparticles as potential agents against cystic echinococcosis in addition to the applying of Nano-carriers drug delivery system that promises to further extend the treatment options.

show abstract

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Abstract: Background: Cystic echinococcosis is a zoonotic disease with

Cited by 7 publications

References 50 publications

The Anti-Echinococcus Potential of Botanicals and Nano Green Particles: Recent Updating

The Anti-Echinococcus Potential of Botanicals and Nano Green Particles: Recent Updating

The efficiency of fabricated Ag/ZnO nanocomposite using Ruta chalepensis L. leaf extract as a potent protoscolicidal and anti-hydatid cysts agent

Advances in the Use of Nanoparticles as Anti-Cystic Echinococcosis Agents: A Review Article

Contact Info

Product

Resources

About