Evaluation of in vitro antioxidant and anti-inflammatory activities of Ximenia americana extracts

Shettar, Arun Kashivishwanath; Kotresha, Katrahalli; Kaliwal, B.B.; Vedamurthy, A. B.

doi:10.1016/s2222-1808(15)60957-4

Cited by 23 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Shettar [ 13 ] reported the presence of flavonoids in phytochemical analysis and their high antioxidant potential of the aqueous extract of X. americana leaves. His studies suggest that leaves can be used as natural antioxidants to prevent the incidence and progression of many diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In ethnomedicine, X. americana stem bark is used as an astringent and healing agent, and is also indicated for the treatment of wounds, skin and mucosal ulcerations, gastritis and stomach discomfort [ 9 ]. Some studies have explored its ulcer healing, anti-inflammatory [ 10 , 11 ], analgesic [ 12 ], antioxidant [ 13 , 14 ], antimicrobial [ 15 ], antihelmintic [ 16 ] and anticancer [ 17 ] action.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

et al. 2018

View full text Add to dashboard Cite

Ximenia americana L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of X. americana (XaAE) and evaluated its antiulcerogenic activity. After lyophilization, XaAE was analyzed by liquid chromatography-mass spectrometry (LC-MS) and its antiulcerogenic effect was evaluated in acute gastric lesions induced by ethanol, acidified ethanol, and indomethacin. Antisecretory action, mucus production and the participation of sulfhydryl groups (–SH) and nitric oxide (NO) were also investigated. The chromatographic analysis identified procyanidins B and C and catechin/epicatechin as major compounds. Oral administration of XaAE (100, 200 and 400 mg/kg) inhibited the gastric lesions induced by ethanol (76.1%, 77.5% and 100%, respectively), acidified ethanol (44.9%, 80.6% and 94.9%, respectively) and indomethacin (56.4%, 52.7% and 64.9%, respectively). XaAE reduced gastric contents and acidity (51.4% and 67.7%, respectively) but did not alter the production of gastric mucus. The reduction of the -SH and NO groups promoted by N-ethylmaleimide (NEM) and Nω-nitro-l-arginine-methyl-ester (L-NAME) respectively, reduced the gastroprotective effect of XaAE. In conclusion, XaAE has gastroprotective activity mediated in part by -SH, NO and antisecretory activity. This antiulcer action was initially correlated to its major constituents, procyanidins B and C and catechin/epicatechin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Poincianella pyramidalis has been shown to be a gastroprotector [96] whose mechanism of action involves a reduction of the endogenous hydrogen sulphate content and reduction of the inflammatory process [97]. Although there is no direct evidence for the gastroprotector activity of Ximenia americana and Ziziphus joazeiro , its use by the community for this therapeutic purpose may correlate with its anti-inflammatory, cicatrizing, and antioxidant potential [96, 98, 99]. Studies have shown that Tocoyena formosa has anti-inflammatory [100], antinociceptive [101], and gastroprotective activities [102].…”

Section: Resultsmentioning

confidence: 99%

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Macedo

Menezes

Ribeiro

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Ethnopharmacological Relevance This study aims to evaluate the versatility of these species and their agreement of use and/or the informants' knowledge and verify the variability of the information on the indicated medicinal species in comparison to other species from northeastern Brazilian areas. Materials and Methods Ethnobotanical information was acquired through interviews with 23 residents of the Quincuncá community, northeastern Brazil. From the obtained data, a comparative analysis of the therapeutic indications with other 40 areas in different biomes was conducted. For that, the relative importance index and informant consensus factor were calculated and compared to other indices evaluated in the literature. Results A total of 39 medicinal species were cited and twenty-six species showed similarities among their therapeutic indications; however, species as Geoffroea spinosa, Lantana camara, and others can be highlighted, present in community disease indications that were not verified for other areas. Myracrodruon urundeuva, Mimosa tenuiflora, Stryphnodendron rotundifolium, and Amburana cearensis had the greatest versatility. In the Quincuncá community, medicinal species were indicated for 49 diseases, which were grouped into 15 categories of body systems. Conclusion This study shows the presented divergence in relation to their therapeutic use; in this point, these divergences reinforce the importance of pharmacological research.

show abstract

“…A 23 Todos os outros fitoconstituintes presentes na X. americana também são compostos bioativos, com atividades farmacológicas conhecidas, o que dá a essa planta grande potencial para a produção de fitoterápicos. A esses constituintes são atribuídas as suas atividades antioxidante, 24 anti-inflamatória, 18,25 antinociceptiva, 26,27 antimicrobiana, 28 moluscicida, 29 gastroprotetiva, 30 hepatopropetora e hipoglicemiante. 31…”

Section: Perfil Fitoquímicounclassified

Evaluation of Hydroalcoholic Extracts of Stem and Leaves of Ximenia Americana L. in the Healing of Excisional Acute Wounds in Mice

Palma¹,

Marques²,

Carneiro³

et al. 2020

Rev. Virtual Quim.

View full text Add to dashboard Cite

The healing activity of hydroalcoholic extracts at 2.5 % of leaves, wood and stem bark of Ximenia americana L. was experimentally investigated in surgically induced skin wounds in mice. The phytochemical study revealed the presence of tannins, flavonoids, saponins and steroids. The wound regression percentage was higher in the groups treated with the plant at 14 (80 %) and 21 days (100 %) when compared to the negative control group, and there was a significant reduction (p <0.05) in mononuclear cells number. The fibroplasia process was more evident in the group treated with the stem bark evidenced by the significant increase of fibroblasts, reaching more than 150 % in 21 days period. Hydroalcoholic extracts of X. americana were favorable to the healing process through wound regression, inflammatory cells reduction and increase of fibroblasts number. A atividade cicatrizante dos extratos hidroalcoólicos a 2,5 % das folhas, cascas e madeira do caule de Ximenia americana L. foi investigada experimentalmente em feridas cutâneas cirurgicamente induzidas em camundongos. O estudo fitoquímico revelou a presença de taninos, flavonoides, saponinas e esteroides. O percentual de regressão da ferida foi maior nos grupos tratados com a planta aos 14 (80 %) e 21 dias (100 %) quando comparados ao grupo controle negativo, havendo também redução significativa (p<0,05) do número de células mononucleares. O processo de fibroplasia foi mais evidente no grupo tratado com a casca do caule evidenciado pelo aumento significativo de fibroblastos, chegando a mais de 150 % no período de 21 dias. Os extratos hidroalcoólicos da X. americana mostraram-se favoráveis ao processo de cicatrização através da regressão da ferida, redução de células inflamatórias e aumento do número de fibroblastos.

show abstract

Evaluation of in vitro antioxidant and anti-inflammatory activities of Ximenia americana extracts

Cited by 23 publications

References 33 publications

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Evaluation of Hydroalcoholic Extracts of Stem and Leaves of Ximenia Americana L. in the Healing of Excisional Acute Wounds in Mice

Contact Info

Product

Resources

About