Evaluation of In Vitro Antidiabetic and Antioxidant Activities and Preliminary Phytochemical Screening of Leaf Extracts of Avicennia officinalis

Abstract

Avicennia officinalis is a medicinal mangrove plant and used in traditional folk medicine for treatment of various ailments. In the present study, the antidiabetic and antioxidant activities of petroleum ether and aqueous extracts of leaves of A. officinalis were evaluated. The antidiabetic activity was evaluated out by α-amylase and α-glucosidase inhibition study and antioxidant capacity by DPPH, superoxide and hydrogen peroxide scavenging activity of leaf extracts at various concentrations. The maximum antidiabetic activity was observed in 1.0 mg/ml of leaves extract of aqueous extracts. The maximum superoxide and hydrogen peroxide scavenging activity were exhibited by aqueous extracts with IC 50 values of 0.27 and 0.17 mg/ml respectively and maximum DPPH scavenging activity was shown by petroleum ether extracts with IC 50 value of 0.25 mg/ml. The qualitative and quantitative phytochemical analysis also showed presence of different phytochemicals including phenols, flavonoids and tannins which may be attributed to their antidiabetic and antioxidant activities. Thus, the present study gives a clear evidence that leaf extracts of A. officinalis possess both antidiabetic and antioxidant activities.

The Evaluation Of Pharmacological Activity Of Potential Mangrove Avicennia Officinalis & Heritiera Fomes: A Review Article

“…Notably, the aqueous leaf extract exhibited superior inhibition of these enzymes compared to the petroleum ether extract. [33]…”

“…Furthermore, petroleum ether and aqueous leaf extracts showcased antioxidant capacity in assays targeting DPPH, superoxide, and hydrogen peroxide scavenging, with IC50 values ranging from 0.17 to 0.27 mg/ml. Additionally, ethanol extracts from both bark and leaf demonstrated a dose-dependent scavenging capacity against superoxide radicals, DPPH, and ABTS, with IC values ranging from 82 to 207.6 µg/ml [36,50,51] .…”

Establishment of a standardized ethanolic extract of Avicennia officinalis leaves in Vietnam

“…This plant's stem or bark is used traditionally as diuretic, antiulcer, therapy for snakebite, rheumatism, skin conditions, hepatitis, antitumor, antibacterial, gastroprotective, boils, and abscesses. Pharmacological studies have demonstrated the antibacterial, antiulcer, anti-inflammatory, anti-cancer, and antioxidant activities of several Avicennia officinalis leaf and bark extracts (Bhimba et al, 2010;Kumar et al, 2017;Ngoc-Van et al, 2022). The majority of this plant's distribution is in Malaysia, Bangladesh, India, and Indonesia.…”