Evaluation of in vitro Anticataract Activity and Aldose Reductase Potential of Barleria lupulina Lindl.

Mazumder, Papiya Mitra; Rathinavelusamy, Paramaguru; Mohanty, Anuradha; Sasmal, D.

doi:10.5567/pharmacologia.2014.172.176

Cited by 4 publications

(7 citation statements)

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“…However, synthetic antioxidants, like ascorbic acid was found to be more potent for providing the hydrogen electron transfer ability than the samples of the plant extract. Similar work has been reported earlier by Mazumder et al [ 16 ] who found varying IC 50 values of different organic solvent soluble extracts. They adopted different extraction procedures due to which IC 50 values also differed from our findings.…”

Section: Discussionsupporting

confidence: 91%

“…Phytochemical analysis of ethanolic extract of B. lupulina revealed the presence of steroid, glycoside, terpenoid, flavonoid, tannin and carbohydrate as reported by Sur and Das [ 29 ] and Mazumder et al [ 17 ]. Presence of more or less similar phytoconstituents in varying amount in different solvents has also been reported by the other workers [ 6 , 16 , 20 , 21 ]. These results are similar to that of ethanolic extract recently reported by Kumari and Dubey [ 11 , 12 ].…”

Section: Discussionsupporting

confidence: 81%

“…A similar relationship between phenolic and antioxidant activity has also been reported in ethyl acetate fraction of B. lupulina (EFBL) showing the highest value of TPC, followed by methanol soluble extract, and acetone soluble fraction phenolic and flavonoid content, which are responsible for antioxidant property of plants [ 16 ]. We found better results than Mazumder et al [ 16 ] and report the antioxidant properties even in least amount of extracts. The phenolic compounds may contribute directly to antioxidative action [ 7 ].…”

Section: Discussionsupporting

confidence: 67%

“…Doss et al [ 6 ] have also reported the presence of alkaloids, tannins, steroids, and flavonoids only in petroleum ether, chloroform and methanol soluble extracts. Mazumder et al [ 16 ] have reported the presence of flavonoid, sterol, alkaloid and phenolic compounds in methanol extract of B. lupulina . Similarly, the aqueous fraction of B. lupulina contains alkaloids, reducing sugars and phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl.

Kumari

Kumar

et al. 2017

BMC Complement Altern Med

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BackgroundAntibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication.MethodsThe antibacterial, antioxidant and immunomodulatory properties of B. lupulina (methanol soluble leaf and stem extracts) was analyzed by minimum inhibitory concentration, total phenolic contents, DPPH radical scavenging activity, determination of toxicity, hemagglutination antibody titre, delayed type hypersensitivity and neutrophil adhesion test, respectively.ResultsMethanol soluble leaf extract (MLE) contains more soluble bioactive compounds inhibiting the growth of five bacterial pathogens viz., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhi even at MICs of 1.25 and 2.5 mg/mL. Aqueous stem extract (ASE) was least effective while MLE was highly effective in inhibiting the growth and survival of bacterial pathogens. While testing the effect of these extracts in animal model, no mortality of albino rats was recorded by using MLE and MSE at the concentrations from 200 to 600 mg/kg of their body weight. The MLE showed significant result in agglutination reaction and induced paw edema volumes when compared with untreated group (control). Both MLE and MSE extracts significantly increased neutrophil adhesion with increase in doses of extracts. MLE was found to have more potent immune-stimulant properties than the MSE. High phenolic contents were found in MSE while lowest IC50 values were found in MLE in term of DPPH radical scavenging activity.ConclusionsMethanol soluble leaf and stem extract of Barleria lupulina contains antibacterial, antioxidants and immunomodulating phytochemical compounds that was effective for antibacterial, antioxidant and immunomodulatory properties. These may be used as synthetic drug.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl.

Kumari

Kumar

et al. 2017

BMC Complement Altern Med

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“…Traditionally, leaves of this plant are used to treat snake bites, dog bites, swelling, bleeding wounds and rheumatism. The extracts of the plant also possess anti-HSV-2 activities [9], ameliorate secondary complications of diabetes including cataract [10,11], antiarthritic [12], anti-inflammatory [13], antimicrobial [14], anti-clastogenic, anti-tumor, and anti-cancer activities besides having radiation protection [15].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antibacterial and Cytotoxic Properties of Barleria lupulina Lindl. Extracts

Kumari¹,

Dubey²

2016

J Plant Pathol Microbiol

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(India) during the month of June 2014, and identified by the experts of the department (specimen identification No Bot. and micro/199). The plant leaves were washed with running tap water to remove the adhered dust, dirt and unwanted particles from their surfaces. The leaves were shade dried at room temperature for 15 days and separately homogenized in domestic blender to get fine powders. The powders were stored in airtight container at room temperature for further studies. Bacterial cultures Five standard human enteric pathogenic bacteria viz. Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 27853, Pseudomonas aeruginosa ATCC 25922, Klebsiella pneumoniae MTCC 432 and Salmonella typhi MTCC 733 were procured from the Laboratory of the Departmental of Botany & Microbiology, Gurukula Kangri University. All the pathogens were sub cultured on nutrient agar slants and preserved at 4ºC for further study.

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GenusBarleriaL. (Acanthaceae): a review of its taxonomy, cytogenetics, phytochemistry and pharmacological potential

Lekhak

Patil

Deshmukh

et al. 2022

Journal of Pharmacy and Pharmacology

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Objectives Barleria, a large genus of the Acanthaceae family, comprises more than 300 species with diverse taxonomy, cytogenetics, phytochemistry and pharmacological potential. Therefore, the aim of this review is to critically assess the research on Barleria and provide guidance for future investigations. Methods The data were obtained from different sources, such as books, theses, journals and some of the websites and internet-based searches, published from 1901 to 2020. Data obtained from PubMed, Google Scholar, ScienceDirect, online electronic journals, SpringerLink, Wiley, etc. have also been used. Key findings The species of this genus exhibit considerable medicinal properties. Cytogenetical data are scantily available with chromosome counts available for only 24 species. The most common chromosome number is 2n = 2x = 40. So far, 187 compounds are reported from Barleria species. The active principles, their uses, toxicity and pharmacological effects are discussed. Essential oils, flavones, flavonoids, glycosides, terpenes and terpenoids form the major compounds. Summary It is highly recommended that the pharmacological and economic potential of Barleria species should be exploited and more detailed studies and attention be geared towards its utilization and conservation. In addition, to ensure maximum pharmacological benefits and sustainable use, it is necessary to have empirical information explaining its ethnobotanical values as well as commercial potential.

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Evaluation of in vitro Anticataract Activity and Aldose Reductase Potential of Barleria lupulina Lindl.

Cited by 4 publications

References 4 publications

Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl.

Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl.

Phytochemical Analysis and Antibacterial and Cytotoxic Properties of Barleria lupulina Lindl. Extracts

GenusBarleriaL. (Acanthaceae): a review of its taxonomy, cytogenetics, phytochemistry and pharmacological potential

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