Evaluation of in vitro anthelminthic activity of Leucas aspera extracts

Agarwal, Swati; Jacob, Simi; Chettri, Nikkita; Bisoyi, Saloni; Badarinath, D.K.; Vedamurthy, A. B.; Krishna, V.; Hoskeri, H. Joy

doi:10.5530/pj.2011.24.15

Cited by 13 publications

(12 citation statements)

References 9 publications

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“…Among the various test concentrations, ethanol extract 250 mg/ml showed significant anthelmintic activity with death time of 46.33 min as compared to the standard drug at 50 mg/ml that showed paralysis at 31.33 min and death time as 40.67 min. The investigation thus revealed that ethanol extract of C. roseus showed significant antihelmintic activity against Pheretima posthuma supporting the ethnomedical claims of C. roseus as an antihelmintic plant 57 .…”

Section: Antioxidant Potentialsupporting

confidence: 59%

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2013

IJPSR

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Catharanthus roseus is a medicinal herb found in many tropical and subtropical regions around the world. This plant produces a diverse array of secondary metabolites that are pharmaceutically important like vinblastine and vincristine used as chemotherapeutic agents in the treatment of several types of cancers. Low yield of these vinca alkaloids from the plant in vivo and the challenges to meet their high demand worldwide led researchers to develop various in vitro techniques like hairy root culture, callus cultures, shoot cultures, metabolic engineering and regulation studies to increase their production. The present review gives an account of the various phytochemicals derived from the plant and the pharmacological aspects of secondary metabolites studied. Present review also highlights the biotechnological prospects of an efficient and alternative means of production of valuable metabolites from Catharanthus roseus and also from rich microflora residing inside the plant tissues. It gives an emphasis on the need of exploration of diverse niches of endophytes. QUICK RESPONSE CODE

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Section: Antioxidant Potentialsupporting

confidence: 59%

Untitled

2013

IJPSR

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“…e method adopted was as described in literature with modifications [6,16]. Eight groups of test agents were administered to twenty two groups of adult earthworms, with each group containing three earthworms of approximately equal size.…”

Section: In Vitro Anthelminthic Effects Of Crude Extractsmentioning

confidence: 99%

“…Over the years, conventional anthelminthic drugs, such as, albendazole, mebendazole, ivermectin, piperazine, and niclosamide, have been widely patronized to treat helminth infections, in both livestock and humans. However, due to factors such as cost of these medicines [6], their toxic effects [7], and reported cases of resistance development [5], their patronage and usefulness especially among people living in low-middle income countries have been limited and substituted with cheaper alternatives, mainly, herbal medicines [7]. Several studies have documented the traditional or folkloric use of herbal medicines for helminthiases [1,4,8], and scientific justifications have been widely documented for some of these medicinal plants [2,7,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of the In Vitro Anthelminthic Effects of the Leaves, Stem, and Seeds of Carica papaya (Linn) Using the Pheretima posthuma Model

Goku

Orman

Quartey

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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This study was conducted to comparatively assess the anthelminthic activity of leaves, stem bark, and seeds of Carica papaya, in order to identify which of the plant parts possess the highest anthelminthic activity. Three concentrations of ethanolic and hydroethanolic extracts of the plant parts (1 mg/ml, 2.5 mg/ml, and 5 mg/ml) were prepared and tested against Pheretima posthuma using albendazole as the positive control and 0.9% normal saline solution as the negative control. Preliminary phytochemical investigation showed the presence of alkaloids, saponins, and reducing sugars of glycosides present in all the crude extracts of Carica papaya. Tannins were observed only in extracts of the leaves, while fixed oils were only present in the extracts of the seeds. The results of the anthelminthic activity testing indicated that all crude extracts prepared were more effective than albendazole in reducing paralysis time (p<0.0001) and death time (p<0.0001). It was further shown that the extracts from the seeds (SE and SHE) were more effective than the extracts from the stem bark and leaves both in reducing paralysis and death times. Fractionation of SE provided a fraction, SEB, which was more effective than SE both in reducing paralysis and death times (p<0.0001) and was established to contain fixed oils. The outcome of the current study has provided a scientific justification for the preference of the seeds of Carica papaya for the treatment of helminth infections and has shown that the fixed oils present in the seeds could be responsible for such activity.

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“…For the experiment Pheretima posthuma was taken as model. Through several experimental studies 250 mg/ml concentration of ethanol extract is effective in helminthic disease [19].…”

Section: Anti-helminthic Activitymentioning

confidence: 99%

A Review on Phytochemical Constituents and Medicinal Importance of Catharanthus roseus

Anjumole

Sharma²,

Sushma³

2022

JPRI

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In present times, large numbers of medicinal plants are available. Catharanthus roseus (periwinkle) is also an abundant source of medicinal properties. This legendary splendid plant provided the path for new research works. Scientists had discovered the constitution of phytochemicals and its pharmacological importance. It has prolific varieties having great aesthetic value. This evergreen herbaceous plant is mainly used for its antioxidant, anticancerous, wound healing and antimicrobial activity. Several alkaloids, flavonoids and phenol compounds are present in it. Two unique indole alkaloids are possessed by Madagascar periwinkle which are vinblastine and vincristine. Catharanthus is widely used as an ornamental plant and as well as for pharmacological purposes. Now a days, many research reports are coming out about its pharmacological properties. The presence of invaluable phytochemicals in these plants leads to the discovery of effective medicines to cure various diseases. The main agenda of this review paper is to deliver the pharmacological aspects of Catharanthus rosea plant and its present need. Here, a brief description is given about most of the phytochemicals identified in Catharanthus roseus and their medicinal importance that will be helpful for future research studies on this plant.

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Evaluation of in vitro anthelminthic activity of Leucas aspera extracts

Cited by 13 publications

References 9 publications

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Comparative Evaluation of the In Vitro Anthelminthic Effects of the Leaves, Stem, and Seeds of Carica papaya (Linn) Using the Pheretima posthuma Model

A Review on Phytochemical Constituents and Medicinal Importance of Catharanthus roseus

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