Evaluation of <i>in vitro</i> antibacterial activity of <i>Caralluma lasiantha</i> for scientific validation of Indian traditional medicine

Malladi, Sireesha; Nadh, R. Venkata; Babu, K. Suresh; Pullaiah, T.

doi:10.1080/23312009.2017.1374821

Cited by 7 publications

(19 citation statements)

References 36 publications

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“…Alkaloids' mechanism as antifungal by inhibiting topoisomerase enzymes causing cell membrane leakage ( 5), ( 18), (9). The mechanism of action of alkaloids in the extract of the leaves of the future S. palustris and S. androgynus leaves is together to work as an antimicrobial ( 12), ( 18), (1).…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial Activity of Stenochlaena palustris and Sauropus androgynus in Staphylococcus aureus, Escherichia coli and Candidia albicans

Budiarti¹,

Isnaini²,

Dayana³

et al. 2021

BBRJ

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Stenochlaena palustris and Sauropus androgynus are known to contains antimicrobial substances such as flavonoids, saponins and tannins compounds.The purpose of this study was to analyzes the antimicrobial activity of young and old leaf infusions of S. palustris and S. androgynus leaves against Staphylococcus aureus, Escherichia coli and Candida albicans. Analyze the antibacterial activity of a single preparations with a combination preparation of S.palustris (SP) and S.androgynus (SA) leaves infusion against S.aureus, E.coli and C.albicans. Leaves of S.palustris young part (SP1) taken 0-10 cm from shoots and old parts (SP2) 11-20 cm from shoots, while leaves of S.androgynus young part (SA1) leaves number 1 - 10 from the top and the old part (SA2) leaves number 11-20 from the top. The results showed that a single infusion of SP1 75% and SP2 75%, SA1 90% and SA2 90%, and a combination of SP1 75% and SA1 75%, SP2 75% and SA2 75% have the same activity as ampicillin in S.aureus. Single infusion of SP1 90% and SP2 90%, SA1 90% and SA2 90%, combination of SP1 75% and SA1 80% and the combination of SP2 80% and SA2 60% have the same activity as ciprofloxacin in E. coli. Single infusion of SP1 90% and SP2 90%, and a combination of SP1 80% and SA1 80%, SP2 80% and SA2 80% have the same activity as ketoconazole in C.albicans. The difference in activity due to differences in leaf parts used only occurred in E. coli, whereas in S.aureus and C.albicans (p <0.05).

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Section: Resultsmentioning

confidence: 99%

“…The tannin inhibited the reverse transcriptase and DNA topoisomerase enzymes so that bacterial or fungal cells could not formed. Tannins are toxic and can affect changes in cell membrane permeability and reduce the volume of bacterial or fungus cells (2), ( 5), (9).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Stenochlaena palustris and Sauropus androgynus in Staphylococcus aureus, Escherichia coli and Candidia albicans

Budiarti¹,

Isnaini²,

Dayana³

et al. 2021

BBRJ

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“…B. lasiantha) belongs to the subfamily Asclepiadoideae and its local name is Kundeti Kommulu (in Telugu)/Sirumankeerai (in Tamil). [64] Recent publications report about its biological activities such as antibacterial, [65] hyperglycemic, [66] cytotoxic, [67,68] antioxidant, [69] and immunostimulating. [70] Its vital role in the Indian Traditional Medicine was reviewed by Malladi et al [71]…”

Section: Caralluma Europaeamentioning

confidence: 99%

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Nadh¹

2018

AJP

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In history, medicinal plants were proven as a source of active compounds with therapeutic applications, and at present, they are an important collection for the discovery of novel drug leads. Caralluma is a genus used as traditional medicine. The present article thoroughly reviewed about the classification of Caralluma into subgenera, number of its species, its distribution in different parts of the world, and pharmacological activities exhibited by different species of Caralluma.

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“…Several members of the genus Caralluma are succulent perennial edible plants with several traditional uses such as antiinflammatory, antidiabetic, antirheumatic, antiulcer, and wound healing [15,16]. Several Caralluma species or their phytoconstituents showed a wide spectrum of antimicrobial activity against fungi, Gram-positive and Gram-negative [17][18][19][20][21]. The major bioactive molecules identified in the members of the genus Caralluma are pregnane glycosides, flavone glycosides, terpenoids, and sterols showing a lot of therapeutic significance.…”

Section: Introductionmentioning

confidence: 99%

“…antidiabetic [24], antiobesity [25], antiarthritic agent [26], and antiulcer [27]. Several Caralluma species showed a wide spectrum of antibacterial and/or antifungal activity [20,21].…”

Section: Introductionmentioning

confidence: 99%

Bioguided Isolation of Antibiofilm and Antibacterial Pregnane Glycosides from Caralluma quadrangula: Disarming Multidrug-Resistant Pathogens

et al. 2021

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Methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB) present a serious challenge because of their capability to cause biofilm resistance to commonly used antibiotics producing chronic infections and hindering the process of wound healing. In the current study, we investigated the antibacterial activity of Caralluma quadrangula extracts (MeOH, and its fractions CH2Cl2 and n-butanol) against multidrug-resistant MRSA USA300 and A. baumannii AB5057. In vitro, the MeOH extract and both fractions of C. quadrangula significantly inhibited biofilm formation and disrupted previously established biofilm by MRSA and MDRAB at all the tested concentrations (0.625, 0.313, and 0.156 mg/mL). In vivo, C. quadrangula extracts successfully decreased bacterial loads in MRSA-infected skin lesions in mice. Four pregnane glycosides and one flavone glycoside were isolated from the bioactive n-butanol fraction. The isolated compounds (Rus A–E) were tested for their biofilm inhibition and biofilm detachment activities. The results revealed that Rus C was the most active compound (IC50 = 0.139 mmole), while Rus E was the least active (IC50 = 0.818 mmole). These results support the potential use of C. quadrangula extracts or their isolated compounds for hindering the biofilm attachment and the virulence of MRSA and MDRAB and their application as a topical antimicrobial preparation for MRSA skin infections.

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Evaluation of in vitro antibacterial activity of Caralluma lasiantha for scientific validation of Indian traditional medicine

Cited by 7 publications

References 36 publications

Antimicrobial Activity of Stenochlaena palustris and Sauropus androgynus in Staphylococcus aureus, Escherichia coli and Candidia albicans

Antimicrobial Activity of Stenochlaena palustris and Sauropus androgynus in Staphylococcus aureus, Escherichia coli and Candidia albicans

Untitled

Bioguided Isolation of Antibiofilm and Antibacterial Pregnane Glycosides from Caralluma quadrangula: Disarming Multidrug-Resistant Pathogens

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