Evaluation of<i>In-vitro</i>Anti-Inflammatory activity of Petroleum Ether Extract of<i>Butea monosperma</i>Flowers

Yerragunta, Vishwanadham; Saba, Ayesha; Sadia, Ayesha; Begam, Amreen; Fatima, Syeda Kausar; Nausheen, Hajera; Reddy, E. Sathish

doi:10.5958/0974-360x.2016.00143.8

Cited by 4 publications

(3 citation statements)

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“…Moreover, three other compounds detected in the ethyl acetate extract of PBR1 strain, viz. Spiro [5.5] undecane, 1-methylene, 9acridanone, 9-Acridanone, 1-ethoxy-3-methoxy-10-methyl, and fluoxymesterone detected in the ethyl acetate extract of PBR1 strain, exhibited antimicrobial, antiviral, antimalarial, anti-inflammatory, and antianemia activities [45][46][47][48][49]. Similarly, in Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

2023

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Actinomycetia are known for their ability to produce a wide range of bioactive secondary metabolites having significant therapeutic importance. This study aimed to explore the potential of actinomycetia as a source of bioactive compounds with antimicrobial properties against multi-drug-resistant (MDR) clinical pathogens. A total of 65 actinomycetia were isolated from two unexplored forest ecosystems, namely the Pobitora Wildlife Sanctuary (PWS) and the Deepor Beel Wildlife Sanctuary (DBWS), located in the Indo-Burma mega-biodiversity hotspots of northeast India, out of which 19 isolates exhibited significant antimicrobial activity. 16S rRNA gene sequencing was used for the identification and phylogenetic analysis of the 19 potent actinomycetia isolates. The results reveal that the most dominant genus among the isolates was Streptomyces (84.21%), followed by rare actinomycetia genera such as Nocardia, Actinomadura, and Nonomuraea. Furthermore, seventeen of the isolates tested positive for at least one antibiotic biosynthetic gene, specifically type II polyketide synthase (PKS-II) and nonribosomal peptide synthetases (NRPSs). These genes are associated with the production of bioactive compounds with antimicrobial properties. Among the isolated strains, three actinomycetia strains, namely Streptomyces sp. PBR1, Streptomyces sp. PBR36, and Streptomyces sp. DBR11, demonstrated the most potent antimicrobial activity against seven test pathogens. This was determined through in vitro antimicrobial bioassays and the minimum inhibitory concentration (MIC) values of ethyl acetate extracts. Gas chromatography–mass spectrometry (GS-MS) and whole-genome sequencing (WGS) of the three strains revealed a diverse group of bioactive compounds and secondary metabolite biosynthetic gene clusters (smBGCs), respectively, indicating their high therapeutic potential. These findings highlight the potential of these microorganisms to serve as a valuable resource for the discovery and development of novel antibiotics and other therapeutics with high therapeutic potential.

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Section: Discussionmentioning

confidence: 99%

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

2023

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“…[77] The most common method for the synthesis of acridones is Ullmann synthesis. [78] Different natural sources are also found for acridones. One such example is from the leaves of Citrus reticulata as reticarcidone A, an alkaloid of acridone.…”

Section: Acridines and Acridonesmentioning

confidence: 99%

“…Acridones can travel across biological membranes and interact with the nucleotides of biomolecules such as DNA and RNA [77] . The most common method for the synthesis of acridones is Ullmann synthesis [78] . Different natural sources are also found for acridones.…”

Section: Acridines and Acridonesmentioning

confidence: 99%

Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions

Chandramani,

Nair,

Sreekumar

et al. 2023

Eur J Org Chem

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Isatin, also known as indoline‐2,3‐dione, is a fused, N‐heterocyclic aromatic compound first isolated and purified in 1841. Since then, isatin and its derivatives emerged as a hot research topic for the scientific community. The number of research publications on isatin justifies their popularity. Researchers explored isatins and their derivatives as potential candidates in multidisciplinary research areas, including medicinal chemistry, synthetic organic chemistry, and polymer science. Synthetic chemists’ perspective of tailoring isatin and its family members led to more efficient synthesis strategies in which ring‐opening reactions of isatins were particularly significant due to the product's importance. Our investigation aims to group the different types of cascade ring expansion reactions of isatin to synthesise fused heterocyclic compounds such as derivatives of quinolines, quinazolinones, acridines, acridones, and few spiro heterocyclic compounds, all of which highlight an inevitable role in the field of medicinal chemistry.

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The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits

Leiwakabessy,

Yahya,

Fadjar

et al. 2023

RJPT

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Tambelo reportedly has a positive impact on health. Our study investigates the possible effect of tambelo extract as an anti-inflammatory in mice induced by lipopolysaccharide(LPS)Tambelo phytochemistry from liquid chromatography analysis – high-resolution mass spectrometry (LCMS) coupled with NF-κB protein, docking was carried out to pursue anti-inflammatory properties. Thirty Balb/C mice were randomized into six groups: untreated, LPS, dexamethasone + LPS, and tambelo extract with doses of 100, 150, and 200 mg/kg BW + LPS, respectively. The results of this study indicate that there are four compounds which has a high affinity for the target protein. High CD4+CD25+ expression after treatment with fermented products tambelo (BE) significantly attenuated LPS-induced mice (p<0.05). Our findings show that fermentation tambelo protects against induced LPS by maintaining Tregs. Tambelo may have the potential as a food choice due to its anti-inflammatory properties.

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Evaluation ofIn-vitroAnti-Inflammatory activity of Petroleum Ether Extract ofButea monospermaFlowers

Cited by 4 publications

References 0 publications

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions

The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits

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