Evaluation of <i>CERS2</i> Gene as a Potential Biomarker for Bladder Cancer

Aldoghachi, Ahmed Faris; Baharudin, Aminuddin; Ahmad, Umar; Chan, Soon Choy; Ong, Teng Aik; Yunus, Rosna; Razack, Azad Hassan Abdul; Yusoff, Khatijah; Veerakumarasivam, Abhi

doi:10.1155/2019/3875147

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…CerS1 specifically synthesizes C18 ceramide, and while it is highly expressed in the skeletal muscles, it is nearly undetectable in other tissues ( 24 ). CerS2 is mostly expressed in the kidneys and liver, and synthesizes C22-24 ceramides ( 25 ). Ceramides with varying acyl chain lengths may trigger diverse cell responses; hence, different CerS isoforms may create different ceramide species ( 17 ).…”

Section: Biosynthesis and Degradation Of Ceramidesmentioning

confidence: 99%

Role of ceramides in diabetic foot ulcers (Review)

et al. 2023

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diabetes mellitus (dM) is a metabolic disorder, which if not managed properly, can lead to serious health problems over time and impose significant financial burden on the patient, their family and society as a whole. The study of this disease and the underlying biological mechanism is gaining momentum. Multiple pieces of conclusive evidence show that ceramides are involved in the occurrence and development of diabetes. The present review focuses on the function of ceramides, a type of sphingolipid signaling molecule, to provide a brief description of ceramides and their metabolism, discuss the significant roles of ceramides in the healthy skin barrier, and speculate on the potential involvement of ceramides in the pathogenesis and development of diabetic foot ulcers (dFUs). Understanding these aspects of this disease more thoroughly is crucial to establish how ceramides contribute to the etiology of diabetic foot infections and identify possible therapeutic targets for the treatment of dFUs. Contents1. Introduction 2. Biosynthesis and degradation of ceramides 3. Ceramides in the skin 4. ceramides and dFUs 5. ceramides and vessels 6. ceramides and diabetes 7. ceramides and atherosclerosis 8. Mechanism of ceramides in diabetes 9. Mechanism of ceramides in atherosclerosis 10. Shared mechanisms between diabetic complications and dFUs 11. conclusions

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Section: Biosynthesis and Degradation Of Ceramidesmentioning

confidence: 99%

Role of ceramides in diabetic foot ulcers (Review)

et al. 2023

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“…The potential utility of CERS2 as a predictive biomarker of response to oncolytic virotherapy has also been investigated [ 89 ]. Unfortunately, the potential of CERS2 as a predictive biomarker was found to be limited but may have the potential as a therapeutic target for bladder cancer, since the siRNA-mediated downregulation of CERS2 expression resulted in reduced bladder cancer cell migratory potential [ 90 ].…”

Section: Homeobox Genes In Bladder Cancermentioning

confidence: 99%

Homeobox Gene Expression Dysregulation as Potential Diagnostic and Prognostic Biomarkers in Bladder Cancer

2023

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Homeobox genes serve as master regulatory transcription factors that regulate gene expression during embryogenesis. A homeobox gene may have either tumor-promoting or tumor-suppressive properties depending on the specific organ or cell lineage where it is expressed. The dysregulation of homeobox genes has been reported in various human cancers, including bladder cancer. The dysregulated expression of homeobox genes has been associated with bladder cancer clinical outcomes. Although bladder cancer has high risk of tumor recurrence and progression, it is highly challenging for clinicians to accurately predict the risk of tumor recurrence and progression at the initial point of diagnosis. Cystoscopy is the routine surveillance method used to detect tumor recurrence. However, the procedure causes significant discomfort and pain that results in poor surveillance follow-up amongst patients. Therefore, the development of reliable non-invasive biomarkers for the early detection and monitoring of bladder cancer is crucial. This review provides a comprehensive overview of the diagnostic and prognostic potential of homeobox gene expression dysregulation in bladder cancer.

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“…Urothelial cancer is the most common type of BLCA and is classified into muscle‐invasive bladder cancer (MIBC; accounting for 25–30% of the cases) and non‐muscle‐invasive bladder cancer (NMIBC; accounting for 70–75% of the cases). Non‐invasive BLCA presents with limited and superficial lesions, whereas invasive BLCA is characterized by invasion of the muscle layer and is treated with total bladder resection and urinary diversion 4,5 . Epidemiological studies have reported that most NMIBCs are low‐grade, while most MIBCs are high‐grade 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Non-invasive BLCA presents with limited and superficial lesions, whereas invasive BLCA is characterized by invasion of the muscle layer and is treated with total bladder resection and urinary diversion. 4,5 Epidemiological studies have reported that most NMIBCs are low-grade, while most MIBCs are high-grade. 6 The treatment and prognosis of BLCA depend on the degree of local lesion invasion and type: NMIBCs (<T2 stage) are treated with transurethral resection of the bladder tumor, whereas MIBCs (≥T2 stage) are treated with cystectomy or systemic chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Contrast‐enhanced Ultrasound Combined With Elastography for the Evaluation of Muscle‐invasive Bladder Cancer in Rats

Sun

Ren

et al. 2023

J of Ultrasound Medicine

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ObjectivesBy comparing with the control group, we evaluated the usefulness of contrast‐enhanced ultrasound (CEUS) combined with elastography for the assessment of muscle invasion by bladder cancer (MIBC) in a Sprague–Dawley (SD) rat model.MethodsIn the experimental group, 40 SD rats developed in situ bladder cancer (BLCA) in response to N‐methyl‐N‐nitrosourea treatment, whereas 40 SD rats were included in the control group for comparison. We compared PI, Emean, microvessel density (MVD), and collagen fiber content (CFC) between the two groups. In the experimental group, Bland–Altman test was used to assess the relationships between various parameters. The largest Youden value was used as the cut‐off point, and binomial logistic regression analysis was performed to analyze the PI and Emean. Receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic power of parameters, individually and in combination.ResultsThe PI, Emean, MVD, and CFC were significantly lower in the control group than in the experimental group (P < .05). The PI, Emean, MVD, and CFC were significantly higher for MIBC than for non‐muscle‐invasive bladder cancer (P < .05). There were significant correlations between PI and MVD, and between Emean and CFC. The diagnostic efficiency analysis showed PI had the highest sensitivity, CFC had the highest specificity, and PI + Emean had the highest diagnostic efficacy.ConclusionCEUS and elastography can distinguish lesions from normal tissue. PI, MVD, Emean, and CFC were useful for the detection of BLCA myometrial invasion. The comprehensive utilization of PI and Emean improved diagnostic accuracy and have clinical application.

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Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer

Cited by 9 publications

References 34 publications

Role of ceramides in diabetic foot ulcers (Review)

Role of ceramides in diabetic foot ulcers (Review)

Homeobox Gene Expression Dysregulation as Potential Diagnostic and Prognostic Biomarkers in Bladder Cancer

Contrast‐enhanced Ultrasound Combined With Elastography for the Evaluation of Muscle‐invasive Bladder Cancer in Rats

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