Evaluation of <i>Candida albicans</i> allergens reactive with specific IgE in asthma and atopic eczema patients

Khosravi, Alireza; Bandghorai, A. Naseri; Moazzeni, Seyed Mohammad; Shokri, Hojjatollah; Mansouri, Parvin; Mahmoudi, Mahmoud

doi:10.1111/j.1439-0507.2008.01599.x

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…to which 5-17% of children (14,30,31) and 29-65% of adults (30,35,36) with AD develop specific IgE. The sensitisation frequencies of 33-95% for C. albicans in children and adults described earlier (34,37,38) are considerably higher than in the present study, but might be in part explained by ethnically and possibly socioeconomically differences in the study populations. The previously reported sensitisation frequencies to various superantigens of S. aureus are higher in adults (80%) than in children (60%) (15,16), and considerably higher than in the present study for both age groups.…”

Section: Discussioncontrasting

confidence: 83%

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Glatz¹,

Buchner²,

Bartenwerffer³

et al. 2015

Acta Derm Venerol

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The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (> 100 kU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r = 0.549, p < 0.001) and children (r = 0.344, p = 0.005) and with Malassezia spp.-specific IgE in adults (r = 0.429, p = 0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.

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Section: Discussioncontrasting

confidence: 83%

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Glatz¹,

Buchner²,

Bartenwerffer³

et al. 2015

Acta Derm Venerol

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“…Additionally, Candida spp. are considered to be pathogenically important in patients with asthma and has the highest detection rate in asthma children with fungal infection (Khosravi et al, 2009;Liu et al, 2019). Sensitization to Candida spp.…”

Section: Discussionmentioning

confidence: 99%

The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma

Liu

Liang

et al. 2020

Front. Microbiol.

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Dysbiotic airway microbiota play important roles in the inflammatory progression of asthma, and exploration of airway microbial interactions further elucidates asthma pathogenesis. However, little is known regarding the airway bacterial-fungal interactions in asthma patients. We conducted a cross-sectional survey of the sputum bacterial and fungal microbiota from 116 clinically stable asthma patients and 29 healthy controls using 16S rRNA gene and ITS1 sequencing. Compared with healthy individuals, asthma patients exhibited a significantly altered microbiota and increased bacterial and fungal alpha diversities in the airway. Microbial genera Moraxella, Capnocytophaga, and Ralstonia (bacteria) and Schizophyllum, Candida, and Phialemoniopsis (fungi) were more abundant in the asthma airways, while Rothia, Veillonella and Leptotrichia (bacteria) and Meyerozyma (fungus) were increased in healthy controls. The Moraxellaceae family and their genus Moraxella were significantly enriched in asthma patients compared with healthy controls (80.5-fold, P = 0.007 and 314.7-fold, P = 0.027, respectively). Moreover, Moraxellaceae, along with Schizophyllum, Candida, and Aspergillus (fungal genera), were positively associated with fungal alpha diversity. Correlation networks revealed 3 fungal genera (Schizophyllum, Candida, and Aspergillus) as important airway microbes in asthma that showed positive correlations with each other and multiple co-exclusions with other common microbiota. Moraxellaceae members were positively associated with asthma-enriched fungal taxa but negatively related to several healthyenriched bacterial taxa. Collectively, our findings revealed an altered microbiota and complex microbial interactions in the airways of asthma patients. The Moraxellaceae family and their genus Moraxella, along with 3 important fungal taxa, showed significant interactions with the airway microbiota, providing potential insights into the novel pathogenic mechanisms of asthma.

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“…There are two reports on the prevalence of allergies to Candida in Iran: one reported a 0.7% prevalence in patients with rhinitis in Shiraz, and the other reported a 53% prevalence in patients with eczema and asthma in Tehran [41,44]. Candida is a commensal normal flora of the skin, the gastrointestinal tract, and the genitourinary system, although the significance of Candida in allergies is still controversial in the literature [79]; meanwhile, cross-reactivity to other fungal allergens should be considered [80].…”

Section: Discussionmentioning

confidence: 99%

Sensitization to common allergens among patients with allergies in major Iranian cities: a systematic review and meta-analysis

Moghtaderi

Teshnizi²,

Farjadian

2017

Epidemiol Health

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Various allergens are implicated in the pathogenesis of allergic diseases in different regions. This study attempted to identify the most common allergens among patients with allergies based on the results of skin prick tests in different parts of Iran. Relevant studies conducted from 2000 to 2016 were identified from the MEDLINE database. Six common groups of allergen types, including animal, cockroach, food, fungus, house dust mite, and pollen were considered. Subgroup analysis was performed to determine the prevalence of each type of allergen. The Egger test was used to assess publication bias. We included 44 studies in this meta-analysis. The overall prevalence of positive skin test results for at least one allergen was estimated to be 59% in patients with allergies in various parts of Iran. The number of patients was 11,646 (56% male and 44% female), with a mean age of 17.46±11.12 years. The most common allergen sources were pollen (47.0%), mites (35.2%), and food (15.3%). The prevalence of sensitization to food and cockroach allergens among children was greater than among adults. Pollen is the most common allergen sensitization in cities of Iran with a warm and dry climate; however, sensitization to house dust mites is predominant in northern and southern coastal areas of Iran.

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Evaluation of Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients

Cited by 15 publications

References 31 publications

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma

Sensitization to common allergens among patients with allergies in major Iranian cities: a systematic review and meta-analysis

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