Sensitization to common allergens among patients with allergies in major Iranian cities: a systematic review and meta-analysis

Moghtaderi, Mozhgan; Teshnizi, Saeed Hosseini; Farjadian, Shirin

doi:10.4178/epih.e2017007

Cited by 16 publications

(13 citation statements)

References 46 publications

(32 reference statements)

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“…This is consistent with results reported earlier from the same centre [2]. Similarly, recent meta-analysis regional results [41] documented the high rate of sensitization to local pollens (47%), being responsible for the high prevalence of respiratory allergy in the region. They concluded that sensitization to Alternaria and other non-regional aeroallergens only have a minor influence on asthma patients.…”

Section: Discussionsupporting

confidence: 92%

Association of molds and metrological parameters to frequency of severe asthma exacerbation

Al‐Ahmad

Jusufović

Arifhodžić

et al. 2019

Allergy Asthma Clin Immunol

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Background Sensitization to airborne molds may be a risk factor for severe asthma and direct cause of asthma exacerbation (AE). Methods A prospective, 1-year (April 2016–March 2017) study, done in Kuwait Allergy Centre, investigated the link between AEs with exposure to outdoor molds and the role of meteorological parameters in mold sensitized patients and compared with non-allergic asthma patients who had asthma deterioration. The total of 676 adult asthmatics with moderate-severe AEs were included and divided into atopic (85.65%) and non-atopic group. Atopy was defined by positive skin prick test (SPT) to at least one inhalant allergen. Data regarding atopy and asthma severity were collected from patient’s records. Patients with symptoms and signs of acute respiratory infection and patient sensitized to indoor allergens only were excluded. Daily count of local pollens (Salsola kali, Bermuda grass) and molds (Aspergillus, Alternaria and Cladosporium) were obtained from the Aerobiology department. Daily metrological parameters (atmospheric pressure-AP, temperature-T and relative humidity-RH) were provided by Kuwait Environment Public Authority. Count of spores/m 3 and weather variable are shown on weekly basis. The year circle was divided into 4 Seasons (1, 2, 3, 4) accordingly to typical desert climate. Results Sensitization to molds was relatively high but significantly less (25.0%) if compared to the pollens sensitization. The highest number of AEs was in season 4 for both molds and pollens sensitized patients. Seasonal patterns for both allergens were significant and positively correlated with RH and AP. In season 1 only, mold sensitized patients showed higher rate of AEs. Non-atopic patients have been less sensitive to increased RH than atopic. Negative correlation with T was similar in both atopic and non-atopic patients. Conclusion Despite of high rate of sensitization to molds, their significant role in triggering AE was not found in desert environment. Typical desert climate and high allergencity of local weeds outweigh the influence of the molds.

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Section: Discussionsupporting

confidence: 92%

Association of molds and metrological parameters to frequency of severe asthma exacerbation

Al‐Ahmad

Jusufović

Arifhodžić

et al. 2019

Allergy Asthma Clin Immunol

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“…These results can be explained by the assumption that younger children stay more indoor and therefore are more exposed to HDM and cockroaches than older children who play outside baring themselves to animal allergens. Similar conceptual results were found in the following studies: Riyadh (HDM and aspergillus sensitization rates were more common in adults whereas Salsola kali and date palm sanitization were more common in children), 16 Iran (cockroaches sanitization is more prevalent in children <16 years, whereas HDM, pollens, cat dander, and molds were more common in adults >16 years), 20 Jordan (cats and HDM are more common in younger age group) 18 and Saudi Arabia (where HDM is the most prevalent allergen in younger age group). 17…”

Section: Discussionsupporting

confidence: 87%

“…13 Moreover, there was a study in Jordan and two previous studies directed in Iran (one of them was a meta-analysis study) revealed that the most common aeroallergens were pollens followed by HDM and cockroach. [18][19][20] The differences between the results from Gulf states, including ours, with those from Jordan and Iran might be related to genetic, environmental, or geographical/ meteorological factor or even lifestyles.…”

Section: Discussionmentioning

confidence: 65%

Sensitization to Common Allergens Among Children with Asthma and Allergic Rhinitis in Qatar

Zahraldin¹,

Chandra²,

Tuffaha³

et al. 2021

JAA

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Background: Childhood asthma (A) and allergic rhinitis (AR) are common in Qatar. Aeroallergens sensitization is integral in disease pathogenesis and clinical presentation. Determining sensitization patterns assists clinicians in tailoring an efficient medical management. Objective: To determine the aeroallergen sensitization pattern and relationship to clinical parameters. Methods: A retrospective review of children (2-14-years) files with i) Pediatric Allergist/or Pulmonologist confirmed-diagnosis of A, and AR, and ii) positive skin prick test (SPT). Results: Among 473 patients (69.1% males; 30.9% females), aged 7.6 years, family history was positive in 66.3%: 59.4% in A, 64.2% AR, and 78.2% A-AR. The number of allergens/ patients was 2.1±1.7. Median eosinophil count was 400 cells/ul and IgE 287 KU/L. Rates of A, AR, and A-AR varied significantly in children ≤5 years compared to >10 years: A was 43.2% vs 17.8%, and AR 34.5% vs 16.4%. Two hundred and four children (43.1%) were mono-sensitized, 215 (45.5%) oligosensitized (2-3 allergens), and 54 (11.4%) polysensitized (≥4 allergens). A-AR ranked the top number of positive allergens. The commonest aeroallergen was Der p1 (38.1%), followed by Der f (29.0%), cat (22.6%), alternaria (18.8%), American cockroach (18.4%), and dog (14.0%). House dust mite (HDM) and American cockroach were commoner in ≤5 years than older >10-year children (52.5%, 24.1%), while cat and dog allergens were commoner in older ones (37.1%, 21.6%). Conclusion:Family history is quite positive in patients with A and AR. Common aeroallergens include HDM, cats, and alternaria in the young children, while animal allergens were commoner in the older children.

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“…Assuming that 2.5% of asthmatic patients suffer from ABPA, 38,565 (48.2 per 100,000 general population) patients were estimated to have ABPA in Iran. According to a reported rate of fungal sensitization in adults with asthma (19.6%) [38], a total of 302,356 individuals were estimated. The rate of fungal sensitization rises with asthma severity, so assuming a higher rate of 33% being sensitized to fungi in severe asthma [16], 50,907 asthmatic patients have SAFS.…”

Section: Asthma and Allergic Aspergillosismentioning

confidence: 99%

Burden of fungal infections in Iran

Hedayati

Armaki

Charati

et al. 2018

J Infect Dev Ctries

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Introduction: The number of fungal infections occurring each year in Iran is not known. As the burden of fungal disease is a measure used to assess and compare the relative impact of different type of fungal diseases on populations, we have estimated the burden of fungal diseases in Iran. Methodology: We estimated the burden of human fungal diseases based on the specific populations at risk, existing epidemiological data in both local and international databases, and modelling previously described by the LIFE program (http://www.LIFE-worldwide.org). Results: Among the population of Iran (79,926,270 in 2016), 6,670,813 (8.3%) individuals are estimated to suffer from a fungal infection each year. A total of 2,791,568 women aged between 15 and 50 years are estimated to suffer from recurrent vulvovaginal candidiasis, annually. In addition, considering the 13.3% prevalence rate of tinea capitis in children, a total of 2,552,624 cases per year are estimated. The estimated burden of invasive aspergillosis in the 3 groups of patients with hematologic malignancy, lung cancer and chronic pulmonary obstructive disease was 6394 (8.0 per 100,000). The estimate for the burden of allergic disease related to fungi including allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization and allergic fungal rhinosinusitis was 272,095 (340 per 100,000). Based on the 28,663 cases of HIV infection reported, an estimated 900 and 113 cases with pneumocystosis and cryptococcal meningitis are annually anticipated, respectively. Conclusion: Our estimates indicate that the importance of fungal infections is high but overlooked in Iran, which warrants further actions by health care authorities.

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Sensitization to common allergens among patients with allergies in major Iranian cities: a systematic review and meta-analysis

Cited by 16 publications

References 46 publications

Association of molds and metrological parameters to frequency of severe asthma exacerbation

Association of molds and metrological parameters to frequency of severe asthma exacerbation

Sensitization to Common Allergens Among Children with Asthma and Allergic Rhinitis in Qatar

Burden of fungal infections in Iran

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