Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense

Huang, Doudou; Jiang, Yun; Chen, Wansheng; Yao, Fengyan; Huang, Guanghui; Sun, Lianna

doi:10.1016/j.jep.2015.01.014

Cited by 48 publications

(42 citation statements)

References 26 publications

(29 reference statements)

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“…Similarly, in this work, serum creatinine was lower and uric acid higher in the STZ-diabetic group, which could suggest renal impairments associated with diabetic complications [22]. Moreover, serum amylase was significantly elevated in STZ-diabetic rats, which is compatible with diabetic ketoacidosis [24]. However, we found that EAF attenuated diabetes-induced elevations in serum uric acid and amylase.…”

Section: Discussionsupporting

confidence: 63%

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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Background/Aims: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. Results: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZinduced diabetic rats by reduction of renal fibrosis. Conclusion: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.

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Section: Discussionsupporting

confidence: 63%

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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“…Nevertheless, in modern biological science, there have been only a few reports concerning this useful plant. Some studies have reported on antioxidant and anti-cancer cancer properties of P. chinensis, as well as on potential hepatoprotective, antiviral and anti-diabetic uses (Cao et al 2015;Hu et al 2015;Huang et al 2015;Lu et al 2012;Wang et al 2015;Zhang et al 2013). Certain bioactive compounds including quercitrin, quercetin-3-O-rhamnoside, gallic acid, β-sitosterol, thonningianins A, 5-hydroxy-flavanone-7-Obeta-D-glucoside, 2,4,6-trihydroxybenzoic acid, pinocembrin-7-O-beta-glucoside, 5-methoxy-pinocembrin-7-O-β-D-glucoside and pinocembrin-7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-beta-glucose have been isolated from this plant species (Feng et al 2001;Lu et al 2012;Wang et al 2006Wang et al , 2014.…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Rapid and accurate genetic authentication of Penthorum chinense by improved RAPD-derived species-specific SCAR markers

Mei

Zhang

2017

Biodiversitas

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Abstract. Mei Z, Khan MA, Zhang X, Fu J. 2017. Short Communication: Rapid and accurate genetic authentication of Penthorum chinense by improved RAPD-derived species-specific SCAR markers. Biodiversitas 18: 1243-1249. For the genetic identification and authentication of living organisms, development of Sequence-Characterized Amplified Region (SCAR) markers from Random Amplified Polymorphic DNA (RAPD) fragments is a valuable molecular approach. By using SCAR markers, molecular analysis is simplified to a Polymerase Chain Reaction (PCR) analysis using PCR primers designed from specific sequences of the RAPD amplicons. In this study, RAPD fragments from improved RAPD amplification of a perennial herb Penthorum chinense Pursh from China were cloned into a T-vector, and positive clones were identified by PCR amplification, and sequenced with the Sanger sequencing method for the SCAR marker development. Five SCAR markers were developed that were very specific to P. chinense, and deposited in GenBank (accession numbers: KX671029, KX671030, KX671031, KX671032 and KX671033). BLAST searches of these five nucleotide sequences in the GenBank database showed no identity with markers from other species. This study was developing five specific SCAR markers, has enabled reliable genetic identification of the herbal plant species Penthorum chinense Pursh, useful for authenticating future samples of this important medicinal herb.

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“…Even with the progress in diabetes control by synthetic drugs and insulin, research involving plants and natural products for the control and treatment of the disease is still necessary, given the high cost of drugs and their side effects as well as the popular use of plants with supposedly effective antidiabetic activities [26]. In recent years, research on plants and isolated compounds has reported antidiabetic activity of plant products [25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense

Cited by 48 publications

References 26 publications

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Short Communication: Rapid and accurate genetic authentication of Penthorum chinense by improved RAPD-derived species-specific SCAR markers

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

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