Evaluation of Hypoglycemic effect of extracts from Derris scandens and Thunbergia erecta leaves in Swiss albino mice

Bhuiyan, Md. Mahbubur Rahman; Nahar, Ummey Jannatun; Begum, Anawara

doi:10.5958/0974-360x.2019.00587.0

Cited by 8 publications

(7 citation statements)

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“…When passed through humans at approximately 50 kg of body weight, the plants can be taken up to 2500-1 00 000 mg (2.5-100 g) to reach a moderate hazard according to the WHO [15] referring that doses of T. alata and T. erecta extracts under 2.5-100 g, should be saved for consumers. Concerning these data, usages of T. erecta reported [11][12][13]19] in cooking, eating as a vegetable and application of its leaves for a remedy of headache, should be carefully determined for the doses. However, it is not surprise that T. alata leaf extracts can have activity against Pseudomonas aeruginosa and have significant antibacterial activity against Salmonella typhi [20] , according to their biological activities including DNA damage in normal and poisoned PBMCs, which can be assumed to occur at plant concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…T. erecta, including leaves, stems, roots and flowers, could be exploited for the green synthesis of zinc oxide nanoparticles, which can be used in the development of pharmaceutical products beneficial to mankind [11] . Bhuiyan et al [12] researched T. erecta, a medicinal plant with many reported phytochemicals and significant medicinal value and revealed that the methanol leaf extract has hypoglycemic effects in an animal model. The most recent research reported experimental results in swiss albino mice with T. erecta, which contained phytoconstituents, flavonoids, glycosides, tannins saponin, carbohydrates and alkaloids and possessed sedative and anxiolytic activity traditionally used in insomnia, depression and anxiety management [13] .…”

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confidence: 99%

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Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

Suwannakud¹,

Boonthai²,

Noikotr³

et al. 2021

ijps

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Saemram et al.: Efficiency Evaluation of Thunbergia alata and Thunbergia erectaThunbergia alata and Thunbergia erecta have been mostly used for ornamentation but have interesting other uses. However, toxicity and phytochemical studies of these plants are lacking. Therefore, phytochemicals of the two species were investigated by gas chromatography-mass spectrometry, cytotoxicity and genotoxicity were tested via 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide and comet assays in normal human peripheral blood mononuclear cells. Then, the extracts of the two species and their combination were applied to peripheral blood mononuclear cells poisoned with rice whisky and bathroom cleaner as toxic models in everyday life. The results showed that the major phytochemicals were 12.36 % and 24.90 % phytol in ethanol extracts of Thunbergia alata and Thunbergia erecta and 46.29 % and 43.47 % oleamide in hexane extracts of Thunbergia alata and Thunbergia erecta, respectively. Half-maximal inhibitory concentration values, which indicate toxicity in cells, were not detected for either species, but at the deoxyribonucleic acid level, the extracts induced significant deoxyribonucleic acid damage, shown by high Olive Tail Moment values in peripheral blood mononuclear cells (p<0.05). Biological activity of the extracts revealed by higher cell viability percentages and lower Olive Tail Moment values in the treatments (poisoned peripheral blood mononuclear cells treated with plant extracts) than the controls (poisoned peripheral blood mononuclear cells). Taking all the results together, Thunbergia alata and Thunbergia erecta extracts and their combination can be applied for many benefits in humans following properties that have been previously used and their phytochemicals but have limitations of doses.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

Suwannakud¹,

Boonthai²,

Noikotr³

et al. 2021

ijps

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“…Blood sugar level was measured after 120 minutes of oral gavage of glucose by glucometer, which works based on the principle of glucose oxidation method. Blood sugar lowering in percent was calculated by using the formula stated below [9]. Percent lowering of blood glucose level = (1 -We/Wc) X 100.…”

Section: Hypoglycemic Effect Evaluation By Oral Glucose Tolerance Tesmentioning

confidence: 99%

Evaluation of Antihyperglycemic and Antioxidant Activity of Fruits, Stems, and Leaves of Zanthoxylum Budrunga

Bhuiyan¹,

Nahar²,

Begum³

et al. 2019

SJMPS

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Zanthoxylum budrunga is a tree worthy of investigation due to its many reported phytoconstituents and properties of rich medicinal value. A comprehensive study on the fruits, stems, and leaves of Z. budrunga was carried out to find out and assess the blood glucose lowering capacity as well as antioxidant potential. In vivo Oral Glucose Tolerance Test (OGTT) and in vitro 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging methods were applied to assess the hypoglycemic and antioxidant potentials of the plant extracts. Methanolic extract of Z. budrunga fruits (MZBF), methanolic extract of Z. budrunga stems (MZBS), and methanolic extract of Z. budrunga leaves (MZBL) showed graded dose-response relationship in OGTT. Most potent blood sugar level reduction was at the highest dose of 400mg/kg body weight with the values of 44.26%, 39.61%, and 36.98% for MZBF, MZBS, and MZBL respectively. Also MZBF, MZBS, and MZBL showed synergistic action with Glibenclamide with the value of 50.34, 43.02, and 45.11% blood glucose reduction, respectively. Comparative order of antioxidant activity was as fruits (IC 50 30.6 ppm)>leaves (IC 50 68.38 ppm)>stems (IC 50 126.83 ppm) where ascorbic acid (IC 50 0.17 ppm) was used as standard. The results indicate that Z. budrunga fruits, stems, and leaves have the potential to be used in hyperglycemic condition as folk medicine. Besides these, fruits and leaves may be used as functional food and preventive medicine for oxidative stress disorders like aging-induced disorders, neurodegenerative diseases, liver diseases, cancer etc.

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“…Inside Bangladesh, Teknaf of Cox's Bazar district and Nijhum Dweep are its native range. This plant is locally known as Kalilata in this country (Bhuiyan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have isolated a plethora of compounds from D. scandens. Isolated and characterized chemical constituents include coumarins, phenyl coumarins, triterpenes, isoflavones, flavones, isoflavone glycosides, and steroids (Bhuiyan et al, 2019;Madhiri and Panda, 2018). Traditionally, D. scandens plant extract has mostly been used for its analgesic property.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antimicrobial and Membrane Stabilizing Properties of Leaf and Stem Extracts of Derris scandens (Roxb.) Benth. (Family: Fabaceae)

Shahriar¹,

Jaman²,

Saha³

et al. 2023

Bangla Pharma J

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Derris scandens (Roxb.) Benth. (Family: Fabaceae), a recognized medicinal plant colloquially known as ‘Kalilata’ in Bangladesh, has been traditionally used as analgesic in Thailand. This study was intended to evaluate and compare the antimicrobial and membrane stabilizing potentials among the methanol extracts of D. scandens leaf and stem, and their fractionates. The stem and leaves of the plant were extracted by methanol separately and fractioned into aqueous, dicholoromethane (DCM), ethyl acetate and n-hexane soluble fractions. They were tested for antimicrobial activity by using the agar-well diffusion method where ciprofloxacin and fluconazole were used as references. The highest antimicrobial activity was observed against a Gram-negative bacteria (Escherichia coli) by the DCM soluble fraction of the leaf and stem extracts with 20 mm and 15 mm zones of inhibition, respectively. The n-hexane soluble fraction of methanol extract of stem revealed weak to moderate antimicrobial activity against Gram-positive bacteria. The ethyl acetate soluble fractionates of methanol extracts of leaf and stem showed similar antifungal property against Saccharomyces cerevisiae with a zone of inhibition of 12 mm. The membrane stabilizing potential of the extractives was estimated based on the prevention of hemolysis of RBC prompted by hypotonic solution as well as heat. The n-hexane and DCM soluble fractions of both extracts showed around 75% inhibition of hypotonic solution- and heatinduced hemolysis. All in all, the extracts and several fractionates showed moderate antimicrobial and membrane stabilizing properties and further investigations are warranted to find out active phytoconstituents responsible for these properties. Bangladesh Pharmaceutical Journal 26(1): 67-72, 2023 (January)

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Evaluation of Hypoglycemic effect of extracts from Derris scandens and Thunbergia erecta leaves in Swiss albino mice

Cited by 8 publications

References 0 publications

Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

Efficiency Evaluation and Usages of Thunbergia alata, Thunbergia erecta and their Combination

Evaluation of Antihyperglycemic and Antioxidant Activity of Fruits, Stems, and Leaves of Zanthoxylum Budrunga

Comparison of Antimicrobial and Membrane Stabilizing Properties of Leaf and Stem Extracts of Derris scandens (Roxb.) Benth. (Family: Fabaceae)

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