Evaluation of hypoglycemic and anti –diabetic activity of poly‐herbal formulation in normal and streptozotocin induced diabetic rats

Abstract

The present study was focused to evaluate the hypoglycemic and antidiabetic activity of Maddi Dicare the poly ‐herbal formulation, in both normal and experimentally induced hyperglycemic (Streptozotocin ) rats. Different doses of poly herbal formulation (50, 100 and 200 mg/kg) was administered in rats orally. At the end of the treatment period, the serum from normal and diabetic animals was subjected to the estimation of blood sugar, using glucose kits. Effect of Polyherbal formulation on glucose tolerance was also carried out. It was found to produce significant hypoglycemic activity in both normal and diabetic animals, which could be compared to glibenclamide (10 mg/kg). The Poly‐herbal formulation was found to increase the glucose tolerance in normal rats. The present study demonstrates that herbal formulation exhibits promising anti‐diabetic activity and helps to maintain good glycemic and metabolic control. It also proved hypoglycemic and antidiabetic activity in a dose dependent manner.