Evaluation of human papilloma virus in semen as a risk factor for low sperm quality and poor in vitro fertilization outcomes: a systematic review and meta-analysis

Weinberg, May; Nahshon, Chen; Feferkorn, Ido; Bornstein, Jacob

doi:10.1016/j.fertnstert.2020.01.010

Cited by 33 publications

(28 citation statements)

References 43 publications

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“…Also, results from 5203 men revealed significantly worse conventional sperm parameters in HPV-positive than HPV-negative patients, with the motility being the parameter more strongly associated with HPV-infection. Importantly, a significantly higher miscarriage rate has been reported in HPV-positive patients compared to controls ( 77 ). Finally, if the HPV DNA test is positive, both male and female should be counseled for possible HPV vaccination and followed-up at 3 and 6 months after counseling.…”

Section: Methodsmentioning

confidence: 99%

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple

Garolla

Pizzol

Carosso³

et al. 2021

Front. Endocrinol.

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CapsuleThis expert opinion summarizes current knowledge on risk factors for infertility and identifies a practical clinical and diagnostic approach for the male and female partners of an infertile couple aimed to improve the investigation and management of fertility problems.BackgroundInfertility represents an important and growing health problem affecting up to 16% of couples worldwide. In most cases, male, female, or combined factor can be identified, and different causes or risk factors have been related to this condition. However, there are no standardized guidelines on the clinical-diagnostic approach of infertile couples and the recommendations concerning infertility are sometimes lacking, incomplete, or problematic to apply.ObjectiveThe aim of this work is to provide an appropriate clinical and diagnostic pathway for infertile couples designed by a multidisciplinary-team of experts. The rationale is based on the history and physical examination and then oriented on the basis of initial investigations. This approach could be applied in order to reduce variation in practice and to improve the investigation and management of fertility problems.MethodsProminent Italian experts of the main specialties committed in the ART procedures, including gynecologists, andrologists, embryologists, biologists, geneticists, oncologists, and microbiologists, called “InfertilItaly group”, used available evidence to develop this expert position.OutcomesStarting from the individuation of the principal risk factors that may influence the fertility of females and males and both genders, the work group identified most appropriate procedures using a gradual approach to both partners aimed to obtain a precise diagnosis and the most effective therapeutic option, reducing invasive and occasionally redundant procedures.ConclusionsThis expert position provides current knowledge on risk factors and suggests a diagnostic workflow of infertile couples. By using this step-by-step approach, health care workers involved in ART, may individuate a practical clinical management of infertile couples shared by experts.

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Section: Methodsmentioning

confidence: 99%

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple

Garolla

Pizzol

Carosso³

et al. 2021

Front. Endocrinol.

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“…Among these viruses are the mumps virus (orchitis), human immunodeficiency virus-1 (orchitis and prostatitis), Coxsackie virus (epididymitis), cytomegalovirus (vesiculitis), human papillomavirus and herpes simplex virus (prostatitis) (Dejucq & Jegou, 2001). These infections lead to male infertility by increasing seminal leukocyte concentrations (Karamolahi et al, 2019;Umapathy, Simbini, Chipata, & Mbizvo, 2001;Weinberg, Sar-Shalom Nahshon, Feferkorn, & Bornstein, 2020;Wu et al, 2019). The latter virus can infect the testes and male sex accessory glands (Le Tortorec & Dejucq-Rainsford, 2010).…”

Section: Virusesmentioning

confidence: 99%

The role of infections and leukocytes in male infertility

2020

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Oxidative stress is preempted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, such as superoxide dismutase, catalase and glutathione peroxidase, and several nonenzymatic antioxidants (pro teins, vitamins and minerals), working as oxidant scavengers and cofactors of en zymatic antioxidants have been identified in seminal plasma. The total antioxidant capacity (TAC) is a diagnostic test that can be utilised in the male infertility workup. TAC measures the amount of total antioxidants in seminal plasma. Therefore, it pro vides an assessment of the reductive potential in seminal plasma. Several studies have investigated the diagnostic application of TAC in various andrology conditions. There is substantial evidence in the literature to show that infertile patients have lower seminal TAC in comparison with fertile men. Moreover, there is a positive cor relation between TAC and seminal parameters, such as sperm concentration, motility and morphology. Evaluation of TAC together with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may be beneficial in the diagnosis of male infertility.

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“…A meta‐analysis by Weinberg et al. (2020) showed HPV infection in semen had no effect on sperm concentration, motility and morphology. This study and Weinberg et al had similar results except for sperm viability.…”

Section: Discussionmentioning

confidence: 99%

“…Fedder Our study found that HPV infection of semen could reduce sperm concentration, sperm motility, sperm viability and sperm normal morphology. A meta-analysis by Weinberg et al (2020) include Chinese language studies, whereas we included 5 Chinese language studies.…”

Section: Discussionmentioning

confidence: 99%

Association between human papillomavirus infection and sperm quality: A systematic review and a meta‐analysis

et al. 2021

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Human papillomavirus (HPV) has a high incidence rate in both males and females. HPV infection in women has been shown to affect fertility and lead to foetal death and pregnancy loss. However, research on HPV infection in men is limited. The aim of this study was to study the effect of HPV infection in semen on sperm quality and present the findings of previous studies through a meta‐analysis. Databases including PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, WanFang data and China National Knowledge Infrastructure were searched for relevant studies. A systematic review and meta‐analysis were performed, and 17 studies were included for analyses based on a set criterion. Meta‐analyses indicated that HPV infection in semen significantly reduced sperm concentration (SMD = −0.12, 95% CI: −0.21 to −0.03, p = .009), sperm motility (SMD = −0.55, 95% CI: −0.780 to −0.33, p = .000), sperm viability (SMD = −0.55, 95% CI: −0.780 to −0.33, p = .000) and sperm morphology (SMD = −0.34, 95% CI: −0.61 to −0.07, p = .015). The high‐risk HPV (HrHPV) infection could significantly reduce sperm count (SMD = −0.65, 95% CI: −1.11 to −0.18, p = .007) compared with high‐risk HPV (LrHPV) infection. In conclusion, HPV infection in semen significantly reduced sperm quality, and the HrHPV infection could significantly reduce sperm count compared with LrHPV.

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Evaluation of human papilloma virus in semen as a risk factor for low sperm quality and poor in vitro fertilization outcomes: a systematic review and meta-analysis

Cited by 33 publications

References 43 publications

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple

The role of infections and leukocytes in male infertility

Association between human papillomavirus infection and sperm quality: A systematic review and a meta‐analysis

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