Association between human papillomavirus infection and sperm quality: A systematic review and a meta‐analysis

Wang, Shangren; Liu, Li; Zhang, Aiqiao; Song, Yuxuan; Kang, Jiaqi; Liu, Xiaoqiang

doi:10.1111/and.14034

Cited by 18 publications

(16 citation statements)

References 32 publications

(71 reference statements)

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“…In conclusion, while numerous reviews analyzing the correlation between HPV and male infertility seem to find agreement (84)(85)(86)(87), there are few analyses that speculate about the correlation between HPV and female or couple infertility (64,88). The few reviews available do not seem to find agreement with each other and with many other published studies.…”

Section: Discussionmentioning

confidence: 79%

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

et al. 2021

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A comprehensive literature review was performed to determine the relationship between HPV infection and infertility and the eventual role of the 9-valent vaccine for infertility prevention. The search was extended from January 1997 through July 2021. Data collected from selected articles focused on three main topics: statistical associations between HPV prevalence and assisted reproductive technology (ART) outcome, association between HPV and characteristics of semen, and associations between HPV and miscarriage. Articles that identified HPV genotypes were selected for this review to study the possible role of the 9-valent vaccine in infertility prevention. To date, there is no agreement on the implication HPV female infection has on the fertility and miscarriage rate. Although it can be stated that HPV prevalence among couples with infertility undergoing ART treatment is consistent, it does not seem to affect the performance of oocytes. Otherwise, HPV infection affects sperm parameters, in particular spermatozoa motility. When an association can be found, most cases of HR-HPV involved are those included in the 9-valent vaccine. The correlation between HPV male infection both with asthenozoospermia and increased risk of pregnancy loss could recommend the extension of anti-HPV vaccination to adolescent males along with cancer prevention. Despite the fact that the relation between 9-valent HPV genotypes involved in female infection and miscarriage/infertility is not clear, the impact of this virus on health reproduction is evident. Considering this, the importance of HPV vaccination in adolescent females is confirmed. A vaccine efficacy study could be useful to confirm the importance of primary prevention for couple reproductive health.

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Section: Discussionmentioning

confidence: 79%

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

et al. 2021

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“…One possible explanation for the mechanisms involved could be that HPV-DNA exposure causes SDF and that HPV could be located at the equatorial region of the sperm head and lead to reduced sperm parameters. 83 Most published studies showed a deleterious impact of HPV on sperm progressive motility but did not investigate the impact of HPV infection on sperm vitality. [84][85][86] Interestingly, Boeri et al 84 found that HPV positive men presented with higher SDF rates than those with a negative HPV test, suggesting an increased ROS production and a potential alteration of sperm vitality.…”

Section: Human Immunodeficiency Virusmentioning

confidence: 99%

“…Testicular Viral infection X X Lorusso et al 71 , Wang et al, 79 Wang et al, 83 Erbay et al 94 Varicocele X X Vivas-Acedo et al, 64 Cho et al 68 Dysthyroidism X X Abalovich et al, 58 La Vignera et al, 60 Krassas et al 61 Environmental exposure X X Hardneck et al, 138 Pizzol et al, 144 Martini et al, 129 du Plessis et al 134 Post-testicular ADPKD X X Vora et al, 156 Mieusset et al 157 ASA X Kay et al, 105 Matson et al 106 Idiopathic X X Nduwayo et al, 38 Correa-Pérez et al 128 Mixed Smoking X X Mostafa et al, 121 Hamad et al 120 SCI X X X X Mallidis et al, 39 Brackett et al 154 Age X X Condorelli et al, 63 Brahem et al 117 Genital infection X X X Sanocka-Maciejewska et al, 46 Liu et al 49 Obesity X X X X Salas-Huetos et al, 108 Andersen et al 109 Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; ASA, antisperm antibodies; SCI,spinal cord injury.…”

Section: Blood-testis Barrier Disruption Referencesmentioning

confidence: 99%

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Necrozoospermia: The tree that hides the forest

et al. 2022

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Background: Necrozoospermia is a condition found in 0.2%-0.4% of male infertility cases. The causes of necrozoospermia are multiple: they can be related to testicular and/or post-testicular damage. Additionally, these causes most often involve the production of reactive oxygen species (ROS) and/or sperm DNA fragmentation (SDF) which can reduce the chances of spontaneous pregnancy or affect the outcome of assisted reproductive technologies.Objective: To focus on potential etiologies of necrozoospermia, its diagnosis and its therapeutic management especially before the employment of ICSI.Methods: Authors searched PubMed/Medline, Web of Science, Cochrane Library, Google and Institutional websites for medical subheading terms and free text words referred to "necrozoospermia", "sperm vitality", "sperm viability", SDF and "ICSI". Results:We identified 12 main etiologies of necrozoospermia responsible for either a decrease of sperm vitality, a mild, a moderate or a severe necrozoospermia. In case of a confirmed decreased vitality, a thorough check-up should be conducted and if available, etiological treatment should be proposed. Therapeutic management could also include repeated ejaculations, drug treatments, the use of ICSI with ejaculated or surgically extracted spermatozoa in case of a non-treatable necrozoospermia. Discussion and conclusion:The potential causes of necrozoospermia should be investigated because many of them could be corrected, thus avoiding the use of ICSI. Moreover, if ICSI procedure remains necessary, the therapeutic management of necrozoospermia could also improve the chances of success by reducing oxidative stress and/or SDF.

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“…DISCUSSION: Most men of reproductive age in high or midst-earning nations own cell phones, and with this increase in cellular phone management, there is egoism over the crucial adverse effects of cell phone visibility on a man's being 31 . Cellular telephones produce electromagnetic radiation (EMR), the lowest-stage radiofrequency (RF), at a volume between 800 and 2200 MHz, which the human body can absorb 32 . Cell phones are legally limited to a particular absorption amount (SAR) of 2.…”

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confidence: 99%

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2021

IJPSR

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The study was aimed at knowing the effect of mobile phone electromagnetic radiation (EMR) on fertility in Wistar Albino Rats and to assess the capability of polyphenolic rich Withania somnifera root extract in shielding rat testis against EMR-induced injuries. Methodology: One hundred and forty-four male Wistar Albino Rats were included in the study and grouped in to 4. Group I received a standard diet, Group II exposed to active mobile phone radiation of 2700 MHz fields for 3 hours/day, Group III exposed to 2700 MHz fields for 3 hours/day along with administration of 250 mg/kg aqueous extract of Withania somnifera root (Aq-Wsr) orally and Group IV received standard diet and 250 mg/kg Aq-Wsr during the experimental period of 180 days. Results: Group-II showed a significant decline in the sperm parameters and reduced in-vivo antioxidants. Group III revealed significant augmentation of sperm parameters and regulated the in vivo antioxidants. On microscopic examination, Group II showed irregular seminiferous tubules, atrophy of spermatogonial cells, hyper-cellularity, degenerated spermatozoa, and decreased number of Leydig cells. Conclusion: This research concludes that long-term exposure to EMR results in testicular trauma, which was statistically significant in sperm parameters and microscopic changes of testis in Group II. This study also proved the shielding effect of Withania somnifera root extract against EMR.

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Association between human papillomavirus infection and sperm quality: A systematic review and a meta‐analysis

Cited by 18 publications

References 32 publications

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

Necrozoospermia: The tree that hides the forest

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