Evaluation of human Albumin Use Pattern in a Referral Teaching Hospital

Nafisi, Sara; Akhavan, Sina; Shiva, Atena; Ghasempour, Mahroo; Dariush, Parisa; Makhdoomi, Khadijeh; Hatamkhani, Shima

doi:10.18502/jpc.v7i3.2350

Cited by 2 publications

(4 citation statements)

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“…Al respecto se han encontrado diversidad de resultados, por ejemplo, Salcedo 12 al analizar a pacientes en servicios especializados en el Hospital Alemán Nicaragüense, encontró que el servicio que más utilizó la albumina fue medicina interna (55%), mientras que Nafisi. 9…”

Section: Resultsunclassified

“…Por otro lado, el estudio de Nafisi9 evidencio que el costo total de albumina para el periodo de estudio fue de 86,500 dólares, pero Farasatinasab 10 reporto que el costo total de albumina fue de 177,000 dólares.Mientras que, de manera mensual, entre los meses de setiembre y octubre el mayor costo mensual de la al-bumina humana al 20% se identificó en el servicio de gastroenterología S/. 39,160.44 y S/.…”

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Consumo de albúmina humana en los servicios de hospitalización del Hospital Militar Central

Quispe

Figueroa

2022

Ciencia e investigación

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Objetivo: Evaluar el consumo de albúmina humana 20% en los servicios de hospitalización del Hospital Militar Central durante el periodo junio - diciembre 2019. Metodología: Estudio tipo observacional, descriptivo, transversal y retrospectivo, cuya muestra estuvo conformada por 1139 registros proporcionados por el servicio de informática de pacientes hospitalizados. Resultados: La edad promedio de los pacientes fue 78,2 años, el 57.8% tenía 80 o más años, el 63,2% fueron varones y el 55.3% tuvieron condición de titular. El medicamento fue prescrito principalmente en hipoalbuminemia (27.37%) y síndrome nefrótico (23.16%). El servicio con mayor atención de pacientes fue medicina interna (50%), pero los de mayores prescripciones de albúmina humana 20% fueron gastroenterología (1539 frascos) y medicina interna (1276 frascos), con un promedio de 61,6 y 13,4 frascos por persona, respectivamente, así como los de mayores costos totales (S/ 173,183.67 y S/ 143,588.28, respectivamente). Conclusión: El consumo de albúmina humana 20% fue prescrito principalmente en pacientes varones, de 80 a más años de edad, con hipoalbuminemia y síndrome nefrótico, atendidos en los servicios de hospitalización por gastroenterología y medicina interna del Hospital Militar Central.

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Section: Resultsunclassified

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Consumo de albúmina humana en los servicios de hospitalización del Hospital Militar Central

Quispe

Figueroa

2022

Ciencia e investigación

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“…The median LOS for patients with severe hypoalbuminemia (cut-off as < 2.5 g/dL) was 20 days (interquartile range 13-33.5). The median LOS for patients with non-severe hypoalbuminemia and a normal albumin level were 18 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) and 11 (2-16) days, respectively. The adjusted mean differences were 6.75 (5.80-7.70; p < 0.001) and 6.67 (5.88-7.46; p < 0.001) days for severe and non-severe hypoalbuminemia, respectively (Table 3).…”

Section: Losmentioning

confidence: 99%

“…The serum albumin correction before surgery in patients with hypoalbuminemia might improve their outcomes. Unfortunately, several studies found that exogenous albumin had been inappropriately prescribed in 63.2-96.0% of cases [13][14][15][16][17]. Prescription control strategies are necessary to reduce the inappropriate use of exogenous albumin.…”

Section: Introductionmentioning

confidence: 99%

The Association of Pre-operative Serum Albumin Levels and Post-operative In-Hospital Death in Patients Undergoing Gastrointestinal Surgeries in Thailand: A Retrospective Cohort Study

Petch-In¹,

Saokaew

Phisalprapa

et al. 2023

Drugs - Real World Outcomes

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Background Pre-operative hypoalbuminemia is known to predict negative outcomes for patients undergoing major surgeries. However, various cut-off points for starting exogenous albumin have been recommended. Objective This study investigated the association between pre-operative severe hypoalbuminemia, in-hospital death, and length of hospital stay in patients undergoing gastrointestinal surgery. Methods A retrospective cohort study using a database analysis was undertaken on hospitalized patients who underwent major gastrointestinal surgery. The pre-operative serum albumin level was classified into three groups: severe hypoalbuminemia (< 2.0 mg/dL) and non-severe hypoalbuminemia (≥ 2.0-3.4 g/dL) and normal level (3.5-5.5 g/dL). To compare between different cut-offs, a sensitivity analysis using another albumin level classification as severe hypoalbuminemia (< 2.5 mg/dL) and non-severe hypoalbuminemia (≥ 2.5-3.4 g/dL) and normal level (3.5-5.5 g/dL) was applied. The primary outcome was post-operative in-hospital death. Propensity-score adjusted regression analyses were applied. Results A total of 670 patients were included. Their average age was 57.4 ± 16.3 years, and 56.1% were men. Only 59 patients (8.8%) had severe hypoalbuminemia. Overall, a total of 93 in-hospital deaths (13.9%) occurred among all included patients, but there were 24/59 (40.7%) deaths among patients with severe hypoalbuminemia, 59/302 (19.5%) deaths among patients with non-severe hypoalbuminemia, and 10/309 (3.2%) deaths among patients with normal albumin level. The adjusted odds ratio for post-operative in-hospital death comparing patients with severe hypoalbuminemia and patients with normal albumin level was 8.11 (3.31-19.87; p < 0.001), while the odds ratio for in-hospital death comparing patients with non-severe and patients with normal albumin level was 3.89 (1.87-8.10; p < 0.001). A sensitivity analysis showed similar findings, the odds ratio for in-hospital death for severe hypoalbuminemia (cut-off as < 2.5 g/dL) was 7. 44 (3.38-16.36; p < 0.001), while the odds ratio for in-hospital death for severe hypoalbuminemia (cut-off as 2.5-3.4 g/dL) was 3.02 (1.40-6.52; p = 0.005). Conclusions Severe pre-operative hypoalbuminemia in patients undergoing gastrointestinal surgery was associated with an increased risk of in-hospital mortality. The risk of death for patients with severe hypoalbuminemia was relatively similar when using different cut-offs such as < 2.0 and <2.5 g/dL.

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Evaluation of human Albumin Use Pattern in a Referral Teaching Hospital

Cited by 2 publications

References 0 publications

Consumo de albúmina humana en los servicios de hospitalización del Hospital Militar Central

Consumo de albúmina humana en los servicios de hospitalización del Hospital Militar Central

The Association of Pre-operative Serum Albumin Levels and Post-operative In-Hospital Death in Patients Undergoing Gastrointestinal Surgeries in Thailand: A Retrospective Cohort Study

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