Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers

Ispaghula Husk-Based Extended Release Tablets of Diclofenac Sodium: Formulation, Evaluation and <i>In vitro</i> Release Studies

“…Thus, drug release from the tablets is swellingcontrolled rather than diffusion-controlled. A similar release mechanism has previously been observed for arabinoxylans-based diclofenac sodium sustained release tablets [6]. The high n value of 0.98 (close to 1) also indicates that the initial 60 % release of loaded drug followed zero order kinetics [15].…”

“…Both recently received attention in tablet technology as disintegrating agent [5] release retardant [6] and floatation agent [7]. The intended application was achieved with the ispaghula/Psyllium alone [6,8] or in combination with other polymers [9].…”

Health-related effects and improving extractability of cereal arabinoxylans

“…There are many techniques available for AXs extraction and different extraction methods will give different yields and range of degrees of branching, molecular weight distribution and tertiary conformation [46], i.e. hot water extraction [21,[47][48][49] and ultrasound-assisted enzymatic extraction [50].…”

Acute toxicity studies of a novel excipient arabinoxylan isolated from Ispaghula (Plantago ovata) husk

“…They have been reported as drug delivery matrix, suspending agent, emulsifying agent, foam stabilizer, binder and disintegrant. (Carvajal et al, 2007;Iqbal et al, 2011;Yadav et al, 2007) No attempt has been made to evaluate the safety of isolated arabinoxylan. The aim of present study was to perform the acute toxicity studies of arabinoxylan isolated by alkali extraction from Ispaghula (Plantago ovata) in two animal species (mice and rabbits) in accordance with the regulatory requirement of excipient (United State Pharmacopeia-NP, 2006) and also perform dermal toxicity, eye irritation and safety pharmacology studies.…”