Acute toxicity studies of a novel excipient arabinoxylan isolated from Ispaghula (<i>Plantago ovata</i>) husk

Erum, Alia; Bashir, Sajid; Saghir, Shazia; Tulain, Ume Ruqia; Saleem, Uzma; Nasir, Muhammad Umar; Kanwal, Farina; Malik, Muhammad Nasir Hayat

doi:10.3109/01480545.2014.956219

Cited by 30 publications

(24 citation statements)

References 7 publications

(7 reference statements)

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“…The physical appearance, mortality rate, body weight, and food and water consumption of the rabbits were observed. After the 15th day, the decapitation of rabbits was carried out for the histopathological examination of their organs …”

Section: Methodsmentioning

confidence: 99%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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The purpose of this study was to develop and characterize chemically crosslinked chondroitin sulfate-co-poly(methacrylic acid) (CSMA) hydrogels for colon targeting of oxaliplatin (OXP) to treat colorectal cancer. CSMA hydrogels were synthesized by freeradical polymerization. Chondroitin sulfate was chemically crosslinked with methacrylic acid in an aqueous medium. Ammonium peroxodisulfate and N,N-methylene bisacrylamide were used as the initiator and crosslinker, respectively. Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy studies were performed to characterize the fabricated polymeric system. The pH-sensitive characteristics of the hydrogels were evaluated by swelling dynamics and equilibrium swelling ratio measurements at pH 1.2 and 7.4. A toxicity study of the developed formulations was also conducted on rabbits to determine the toxicity of the drug-carrier system to the biological system. The characterization studies confirmed the formation of a new polymeric network. A high OXP loading and higher drug release was observed at pH 7.4. The toxicity study confirmed that the developed formulations were nontoxic to the biological system.

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Section: Methodsmentioning

confidence: 99%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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“…Arabinoxylan (AX) from psyllium (Plantago ovata) seed husk, one of the most studied hemicelluloses, presents a great promise for drug delivery formulations [25][26][27][28]. Over past two decades, this polymer has been extensively characterized with regard to its structure and composition [26,[29][30][31][32]. It possesses excellent stability, water-absorption capacity, and excellent film-forming properties, which make it a promising candidate for antibiotic delivering dressings.In the present work, AX-based film dressings have been prepared for the delivery of antibiotics, incorporating gentamicin (GM) as a model drug, to the infected wound.…”

mentioning

confidence: 99%

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

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“…The peak at 1030 cm −1 was recognized as C–O–C stretch of ether. The other peaks observed at 895, 717, and 609 cm −1 were due to polymer backbone bending and these results were compared to those reported by S. Iqbal, S Saghir and a few other researchers, who have done their work on ARX and find in acquiescence to them[ 14 , 20 – 22 ].…”

Section: Resultsmentioning

confidence: 57%

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

2018

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The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate release (IR) layer-forming polymer. Prepared films were subjected to in-vitro drug release, surface morphology, mechanical strength, compatibility of the ingredients, drug contents, ex-vivo mucoadhesion strength and drug permeation. Crossover study design was applied to study the in-vivo pharmacokinetics by using albino rabbits. Various pharmacokinetic parameters including AUC, Cmax, tmax and t1/2 of both drugs loaded in films were compared with standard solution/dispersion administered to the rabbits at the dose of 1mg/kg. The results unveiled instant release and permeation of MLX from IR layer, while good controlled release and permeation characteristics of TZN from SR films over 8 h. films were of uniform thickness with smooth surface and satisfactory mechanical strength. Mucoadhesion strength was sufficient to provide suitable contact time with mucosal membrane. The pharmacokinetic study exhibited prompt absorption of MLX with better AUC 0-t (6655.64 ng/ml*h vs 6538.99 ng/ml*h) and Cmax (436.98 ng/ml vs 411.33 ng/ml) from oral dispersion. Similarly buccal films has shown enhanced half-life (9.91hr vs 2.51 hr), AUC 0-t (1043.4 ng/ml*h vs 149.1 ng/ml*h) and Cmax (91.92 ng/ml vs 42.29 ng/ml) from oral solution. A statistical investigation disclosed a significantly improved pharmacokinetics of TZN and MLX after their absorption across buccal route following administration of buccal film (p<0.05). ARX proved expedient and bilayer buccal films as a drug delivery system ascertained the dual effect of providing instant release of one active agent and persistent release of another one with improved pharmacokinetics.

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Acute toxicity studies of a novel excipient arabinoxylan isolated from Ispaghula (Plantago ovata) husk

Abstract: This study has shown that acute administration of arabinoxylan may be safe.

Cited by 30 publications

References 7 publications

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

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