Evaluation of Hepatotoxicity of Carbon Tetrachloride and Pharmacological Intervention by Vitamin E in Balb C Mice

Mughal, Tafail Akbar; Saleem, Muhammad Zubair; Ali, Shaukat; Anwar, Khawaja Khurshid; Bashir, Muhammad Majid; Babar, M. E.; Khan, Muhammad Azmat Ullah

doi:10.17582/journal.pjz/2019.51.2.755.761

Cited by 26 publications

(18 citation statements)

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“…The energy produced from glucose also helps to battle toxins produced in stress conditions. Increased level of protein contents while the decreased level of hepatic cholesterol, glucose, total lipids and urea has also been observed in Wister Albino rats [20] and Balb C mice after CCl4 treatment [16]. Pre-treatment of Daucus carota extract prohibited CCl4 induced variations in cholesterol, lipids and glucose contents to some level.…”

Section: Discussionmentioning

confidence: 98%

“…The pellet was dried for 24 h in vacuum desiccators after the extraction of lipid. Nucleic acid and protein contents were extracted and estimated by a method mentioned by Mughal et al [16].…”

Section: Lipids Nucleic Acid and Protein Extractionmentioning

confidence: 99%

“…The level of glucose, total lipids, cholesterol, urea, total protein, soluble protein, AST, ALT and LDH in plasma and the saline extract and DNA and RNA only in the saline extract were estimated by the method described by Mughal et al [16].…”

Section: Estimation Of Biochemical Components In Liver and Plasmamentioning

confidence: 99%

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Carbon Tetrachloride-Induced Hepatocellular Damage in Balb C Mice and Pharmacological Intervention by Extract of Daucus Carota

Mughal¹,

Ali²,

Hassan³

et al. 2021

RADS J. Pharm. Pharm. Sci.

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Background: Present research was planned to examine the shielding effect of Daucus carota root extract pre-treatment on the carbon tetrachloride-induced hepatotoxicity in Balb C mice. Objective: To cover the assessment of the enzymatic activity such as Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) and biochemical constituents like cholesterol, protein, lipids, glucose and urea contents in both the blood and liver while RNA and DNA substances exclusively in the liver. Setting: The induction of carbon tetrachloride (CCl4)-induced hepatotoxicity caused a rise in ALT of plasma and a decline in LDH. Method: The mice were treated with CCl4 and Daucus carota extract to check their effect on the level of biochemical constituents. Main Outcome Measure: Daucus carota extract pre-treatment obliterated CCl4-induced variations in the actions of enzymes. Results: cholesterol content decreased while glucose level increased in the blood. Glucose, lipids, cholesterol and urea in the liver were reduced while total protein level rose. Daucus carota extract pre-treatment also prohibited CCl4-induced variations in total protein contents, urea, glucose and lipids in the liver. CCl4 action caused huge hepatic damage. This was averted by Daucus carota extract. Conclusion: These outcomes reveal that Daucus carota root extract pre-treatment inhibited hepatic damage induced by CCl4 in the mice model, which corroborates its defensive effects against hepatic damage produced by both non-oxidative and oxidative mechanisms.

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Section: Discussionmentioning

confidence: 98%

Section: Lipids Nucleic Acid and Protein Extractionmentioning

confidence: 99%

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Carbon Tetrachloride-Induced Hepatocellular Damage in Balb C Mice and Pharmacological Intervention by Extract of Daucus Carota

Mughal¹,

Ali²,

Hassan³

et al. 2021

RADS J. Pharm. Pharm. Sci.

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“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies ( Ali et al, 2020a ; Ali et al, 2020b ; Hussain et al, 2020 ; Ara et al, 2020 ; Ali et al, 2019 ; Khan et al, 2019 ; Mumtaz et al, 2019 ; Mughal et al, 2019 ; Dar et al, 2019 ) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Methodsmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

PeerJ

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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

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“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies (Ali et al, 2020a;Ali et al, 2020b;Hussain et al, 2020;Ara et al, 2020;Ali et al, 2019;Khan et al, 2019;Mumtaz et al, 2019;Mughal et al, 2019;Dar et al, 2019) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Ethical Statementmentioning

confidence: 99%

Figure 1: Electron micrographs of silk fibroin and sericin.

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Evaluation of Hepatotoxicity of Carbon Tetrachloride and Pharmacological Intervention by Vitamin E in Balb C Mice

Cited by 26 publications

References 0 publications

Carbon Tetrachloride-Induced Hepatocellular Damage in Balb C Mice and Pharmacological Intervention by Extract of Daucus Carota

Carbon Tetrachloride-Induced Hepatocellular Damage in Balb C Mice and Pharmacological Intervention by Extract of Daucus Carota

Silk derived formulations for accelerated wound healing in diabetic mice

Figure 1: Electron micrographs of silk fibroin and sericin.

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