Abstract:Premna serratifolia is used by the traditional practitioners as cardiotonic, antibiotic, anti-coagulant, stomachic, carminative, hepatoprotective, antitumor etc. The present study aims in the evaluation of hepatoprotective and in-vitro cytotoxic activity of alcoholic extract of leaves of Premna serratifolia Linn. Hepatoprotective activity is studied by carbon tetrachloride induced hepato-toxicity in rats and the in-vitro cytotoxic activity is carried out by tryphane blue exclusion method using EAC cell lines. … Show more
“…Pharmacologically, it has been reported to have activities such as hepatoprotective (Vadivu et al, 2009), immunomodulatory, cardiac stimulant, antibacterial, cytotoxic, antiarthritic, anti-inflammatory (Biradi and Hullatti, 2013), anti-diabetic (Mujumder et al, 2014), anti-oxidant (Mali et al, 2014), anti-obesity and used in treatment of tumors (Cragg and Newman, 2005).…”
“…Pharmacologically, it has been reported to have activities such as hepatoprotective (Vadivu et al, 2009), immunomodulatory, cardiac stimulant, antibacterial, cytotoxic, antiarthritic, anti-inflammatory (Biradi and Hullatti, 2013), anti-diabetic (Mujumder et al, 2014), anti-oxidant (Mali et al, 2014), anti-obesity and used in treatment of tumors (Cragg and Newman, 2005).…”
“…Unfortunately, so many deaths occur annually from the liver cirrhosis [12]. Liver injuries are commonly caused by viruses, environmental toxicants, drugs and overuse of alcohol that finally leads to different types of hepatic disorders [13,14].…”
“…Kandungan metabolit tersebut juga terdapat pada Buas-buas (Premna serratifolia Linn) seperti alkaloid, flavonoid, tanin, steroid, saponin, terpenoid, dan fenolik (Wahyuni et al, 2014). Metabolit sekunder yang terdapat pada Premna seratifolia Linn dapat dimanfaatkan sebagai tanaman obat, yaitu : stimulus jantung , hepatoprotektif pada daun (Vadivu R et al, 2009) dan ekstrak akarnya (Sigh CR et al, 2011), ekstrak etanol kulit kayu dan kayu memiliki efek kardioprotektif (Rajendran R and Basha NS, 2008).…”
0,125, 0,5, 1, 1,5, 2, dan 2,5 2% (b/v) were obtained the absorptions of 37,95, 74,77, 86,15, 91,03 and 91,69 %, respectively 0,125, 0,5, 1, 1,5, 2, dan 2,5% (b/v) diperoleh absorbsi secara berturut-turut 37,95, 74,77, 86,15, 91,03, dan
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