Evaluation of Hepatoprotective Activity of Carica Papaya and Ficus Bengalensis Latex on Thioacetamide Induced Hepatotoxicity in Rats.

Abstract

Study was designed to evaluate the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/k.g. and Ficus Bengalensis Latex at the dose 300mg/k.g. per oral induced by thioacetamide at the dose 100mg/k.g. S.C..Hepatoprotective activity was observed by using biochemical parameters such as Serum-Glutamate Pyruvate Transaminase and Serum-Glutamate Oxalate Transaminase (SGPT and SGOT), total protein, Bilirubin, Alkaline Phosphate (ALP). Carica Papaya and Ficus Bengalensis Latex produced significant hepatoprotective effect by decreasing the activity of serum enzyme like SGPT, SGOT, Bilirubin, ALP, and elevated total protein level. Both plants latex were found completely prevented the toxic effect of thioacetamide on above serum parameters.

Ficus benghalensis—A comprehensive review on pharmacological research, nanotechnological applications, and patents

“…The liver is a crucial organ that regulates metabolic activities, storage, secretions, and body detoxification (Kumar et al, 2019). So, to ensure the proper functioning of the body, it is very important to protect it from different toxic substances acquired via contaminated food, water, synthetic medicines/drugs, and other factors.…”