Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities

Alara, Oluwaseun Ruth; Abdurahman, Nour Hamid; Alara, John Adewole

doi:10.1007/s13596-020-00481-3

Cited by 36 publications

(18 citation statements)

References 162 publications

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“…Phytochemicals are chemical components, naturally found in different parts of plants, which make many species beneficial for therapeutic uses. Indeed, leaves of papaya are known to have various health-promoting phytochemicals, as it arose from chemical analysis performed in various studies which clearly illustrated the presence of significant amounts of alkaloids, saponins, glycosides, flavonoids, phenolic compounds, enzymes, amino acids, lipids, carbohydrates, vitamins, and minerals [ 13 ]. There were seven flavonoids found in papaya leaves, which were named as quercetin, kaempferol 3-rutinoside, quercetin3-(2G-rhamnosylrutinoside), quercetin 3-rutinoside, kaempferol 3-(2G-rhamnosylrutinoside), myricetin 3-rhamnoside.…”

Section: Phytochemical Composition Of Papaya Leavesmentioning

confidence: 99%

“…Papaya leaves have been identified to have more than fifty bioactive components and therefore useful in the treatment of different human diseases [ 11 , 12 ]. Scientific studies revealed the existence of considerable levels of glycosides, flavonoids, alkaloids, saponins, phenolic compounds, amino acids, lipids, carbohydrates, enzymes, vitamins, and minerals in papaya leaves [ 13 , 14 ]. The crude form of ethyl acetate isolates of papaya leaves has very good antiplasmodial effect against Plasmodium falciparum and P. falciparum -resistant strains [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects

Sharma

et al. 2022

Oxidative Medicine and Cellular Longevity

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The prevalence of viral infections, cancer, and diabetes is increasing at an alarming rate around the world, and these diseases are now considered to be the most serious risks to human well-being in the modern period. There is a widespread practice in Asian countries of using papaya leaves (C. papaya L.) as herbal medicine, either alone or in combination with prescribed medications, to treat a variety of ailments. The importance of conducting the necessary descriptive studies in order to determine the safety of papaya leaf consumption is also emphasized in the context of their application in the healthcare sector. Electronic databases such as Google Scholar, Scopus, and PubMed were used to gather information on papaya leaves, their therapeutic potential, and clinical evidence-based studies. The literature was gathered from publications on papaya leaves, their therapeutic potential, and clinical evidence-based studies. The antidengue, anticancer, antidiabetic, neuroprotective, and anti-inflammatory effects of papaya leaves discussed in this article are supported by evidence from preclinical, in vivo, in vitro, and clinical trial studies, as well as from other sources. Leaves have been investigated for their mechanism of action as well as their potential to be used in the development of novel herbal products for the health business. According to the reports gathered, only a small number of research demonstrated that leaf extract at high concentrations was hazardous to certain organs. The collective literature reviewed in this review provides insights into the use of papaya leaves as a cure for epidemic diseases, highlighting the phytochemical composition and pharmacological attributes of papaya leaves, as well as the results of various preclinical and clinical studies that have been conducted so far on the subject. The review clearly demonstrates the successful medical evidence for the use of papaya leaf extracts in the healthcare system as a supplemental herbal medication in a variety of clinical settings.

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Section: Phytochemical Composition Of Papaya Leavesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects

Sharma

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Another well-known plant, Carica papaya (Caricaceae), a perennial large plant is also greatly acknowledged for its significant biological activities. Several studies have confirmed that the plant and different plant parts have nutritional and medicinal values (Alara et al, 2020). The medicinal uses of C. papaya are extensively described in Ayurvedic literatures.…”

Section: Introductionmentioning

confidence: 97%

Biological properties and HPLC analyses of four medicinal plants extracts obtained at different extraction temperatures

Eyüpoğlu

Etienne²,

Sinan

et al. 2021

Food Processing Preservation

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In the present study, extracts of four medicinal plants (Cajanus cajan, Carica papaya, Morinda morindoides, and Senna alexandrina) obtained at two different extraction temperatures (24 and 45°C) were investigated for their polyphenolic contents, antioxidant, and enzyme inhibitory properties. For instance, extracts of the studied species yielded total phenolic and flavonoid contents in the range of 17.8-66.3 mg GAE/g and 4.18-26.8 mg RE/g, respectively. High performance liquid chromatography (HPLC) coupled with antioxidant assays (HPLC-FRAP and HPLC-DPPH) was employed for direct identification of antioxidant compounds. The extracts showed moderate to high antioxidant potentials in various assays performed (radical scavenging activity: 10.15-240.08 mg TE/g; reducing activity: 24.88-229.59 mg TE/g; metal chelating activity: 5.56-18.32 mg EDTAE/g and total antioxidant capacity: 1.40-2.18 mM TE/g). Additionally, the extracts were found to exert inhibitory properties against all the studied enzymes (anti-acetylcholinesterase: 1.80-2.29 mg GALAE/g; anti-butyrylcholinesterase: 0.19-3.13 mg GALAE/g; anti-amylase: 0.39-0.58 mmol ACAE/g; anti-glucosidase: 0.17-1.36 mmol ACAE/g and anti-tyrosinase: 60.97-73.71 mg KAE/g). Of all, C. cajan extracts were revealed to be the best antioxidants and inhibitors of most enzymes. Therefore, this study demonstrated the pharmacological potentials of the four medicinal plants, especially C. cajan as viable sources of phyto-ingredients that could be of interest in nutraceutical development. Novelty impact statement• The methanol extracts from four medicinal plant with different extraction temperatures (24 and 45°C) were investigated.• HPLC-DPPH and HPLC-FRAP methodologies were used.• Different levels of phenolics in the tested extracts were determined.

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“…They are also involved in scavenging free radicals that cause degenerative diseases in the body . Papaya ( Carica papaya Lin) is a perennial plant that belongs to the Caricaceae family, which originated in southern Mexico . The papaya leaves contain many active components such as papain, chymopapain, cystatin, α-tocopherol, ascorbic acid, flavonoids, cyanogenic glucosides, and glucosinolates that can increase the total antioxidant power in the blood and reduce the lipid peroxidation level .…”

Section: Introductionmentioning

confidence: 99%

“…3 Papaya (Carica papaya Lin) is a perennial plant that belongs to the Caricaceae family, which originated in southern Mexico. 4 The papaya leaves contain many active components such as papain, chymopapain, cystatin, α-tocopherol, ascorbic acid, flavonoids, cyanogenic glucosides, and glucosinolates that can increase the total antioxidant power in the blood and reduce the lipid peroxidation level. 5 Papaya leaf juice is well known and consumed for its purported anticancer activity in the Australian Gold Coast.…”

Section: ■ Introductionmentioning

confidence: 99%

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Oluwajuyitan

Malomo

Badejo

et al. 2020

ACS Food Sci. Technol.

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The demand for low-cost and functional drinks is growing in most of the developing world, where starchy (mainly sugar) foods are the basic staples. In this study, the proximate composition, antioxidant, and phytochemical properties of the extracts from alkalized cocoa powder (ACP) and Carica papaya leaves were determined after blending and mixing them with aqueous and ethanol solvents. The level of crude fiber of the blends was 5-fold higher in 100% C. papaya leaves than in 75% ACP, but the ACP gave a 50% increase in protein content. Notably, C. papaya leaves in the ethanol extract gave higher free DPPH (77.54−85.5%), hydroxyl (83.86−94.16%), and radical scavenging and high metal chelating (32.35−55.82%) activities than the aqueous extract (72.07−83.26%, 71.28−89.83%, and 21.45−56.86%, respectively). On the contrary, ACP increased the phytochemical profiles (total flavonoid, tannin, and total phenols) of the extracts (1.76−2.56%, 12.47−20.58 mg/g, and 11.47−19.01 mg/g, respectively). Hence, the blends are laden with antioxidants that can provide health benefits to consumers.

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Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities

Cited by 36 publications

References 162 publications

Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects

Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects

Biological properties and HPLC analyses of four medicinal plants extracts obtained at different extraction temperatures

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

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